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Researchers discover novel genetic mechanism of idiopathic CD4 lymphopenia

Researchers at National Jewish Health have discovered a novel genetic mechanism of immune deficiency. Magdalena M. Gorska, MD, PhD, and Rafeul Alam, MD, PhD, identified a mutation in Unc119 that causes immunodeficiency known as idiopathic CD4 lymphopenia.

21 Apr 2012

ACT announces dosing of third patient in dry AMD Phase I/II trial

Advanced Cell Technology, Inc., a leader in the field of regenerative medicine, announced today the dosing of the third patient in its Phase I/II trial for dry age-related macular degeneration (dry AMD) using retinal pigment epithelial (RPE) cells derived from human embryonic stem cells.

21 Apr 2012

Possibility to render cancer tumours harmless without affecting other cells

New research findings show how it may be possible to render cancer tumours harmless without affecting the other cells and tissues in the body. The findings apply to cancers including breast, lung and bowel cancer. The study was carried out at Lund University in Sweden.

20 Apr 2012

Potential for gallbladder tissue as source for multipotential stem cells

A new study presented today at the International Liver Congress- 2012 indicates the potential for gallbladder tissue (which is routinely discarded from organ donors and surgical interventions) to be a highly available candidate source for multipotential stem cells.

20 Apr 2012

New evidence helps explain additional health benefits of aspirin

New evidence is helping explain additional health benefits of aspirin. Researchers in Canada, Scotland and Australia have discovered that salicylate, the active ingredient in aspirin, directly increases the activity of the protein AMPK (AMP-activated protein kinase), a key player in regulating cell growth and metabolism. AMPK which is considered a cellular fuel-gauge is switched on by exercise and the commonly used anti-diabetic medication metformin.

20 Apr 2012

Researchers enhance capabilities of solid-state nanopores

The latest advance in solid-state nanopore sensors - devices that are made with standard tools of the semiconductor industry yet can offer single-molecule sensitivity for label-free protein screening - expands their bag of tricks through bionanotechnology.

20 Apr 2012

Chinese scientists make significant breakthrough in animal cloning

Chinese scientists from BGI, the world's largest genomics organization, together with the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences (CAS), and Shihezi University, Xinjiang province, made a significant breakthrough in animal cloning.

20 Apr 2012

New technology delivers electrical signals from brain directly to muscles

A new Northwestern Medicine brain-machine technology delivers messages from the brain directly to the muscles -- bypassing the spinal cord -- to enable voluntary and complex movement of a paralyzed hand. The device could eventually be tested on, and perhaps aid, paralyzed patients.

20 Apr 2012

Breakdown of white-matter pathways affects decision-making as we age

If you are an aging baby boomer and you've noticed it's a bit harder to drive to unfamiliar locations or to pick a new brand of olive oil at the supermarket, you can blame it on the white matter in your brain.

20 Apr 2012

Entire HCV lifecycle can be recapitulated in murine cells

A US study presented today at The International Liver CongressTM 2012 demonstrates that the entire HCV lifecycle can be recapitulated in murine cells, implying that HCV permissive mouse models could soon be developed.

20 Apr 2012

Rare CARD14 gene mutations can lead to plaque psoriasis

Scientists led by Washington University School of Medicine in St. Louis have identified the first gene directly linked to the most common form of psoriasis, a chronic skin condition.

20 Apr 2012

Scientists discover new ways to help detect and treat osteoporosis

Scientists at the University of Sheffield have discovered new ways to help detect and treat the debilitating brittle bone disease osteoporosis.

20 Apr 2012

Social status can affect configuration of neural circuitry

Researchers at Georgia State University have discovered that in one species of freshwater crustaceans, social status can affect the configuration of neural circuitry.

20 Apr 2012

Cholesterol may slow or stop cancer cell growth

A Simon Fraser University researcher is among four scientists who argue that cholesterol may slow or stop cancer cell growth. They describe how cholesterol-binding proteins called ORPs may control cell growth in A Detour for Yeast Oxysterol Binding Proteins, a paper published in the latest issue of the Journal of Biological Chemistry.

20 Apr 2012

Researchers discover new stem cell in the adult brain

Researchers at Lund University in Sweden have discovered a new stem cell in the adult brain. These cells can proliferate and form several different cell types -- most importantly, they can form new brain cells. Scientists hope to take advantage of the finding to develop methods to heal and repair disease and injury in the brain.

20 Apr 2012

Gut microbiota has profound systemic effect on bile acid metabolism

A new study presented today at the International Liver Congress- 2012 demonstrates that the gut microbiota has a profound systemic effect on bile acid metabolism.

20 Apr 2012

HDAC9 gene can lead to obesity-induced body fat dysfunction

Cardiac researchers at the University of Cincinnati (UC) have found that a certain cellular pathway is linked to obesity-related disorders, like diabetes, heart disease and fatty liver disease.

20 Apr 2012

UH to conduct research on causes and treatment of learning disabilities

The National Institutes of Health (NIH) has awarded a five-year, $9 million grant to the University of Houston's Texas Center for Learning Disabilities to conduct research on the causes and treatment of learning disabilities in children and adolescents. UH is one of four universities nationally to receive funding from the NIH for a learning disability research center.

20 Apr 2012

BuruliVac project getting closer to a vaccine

During a meeting in Lisbon, the partners of the BuruliVac research consortium found the project to be running smoothly, and getting closer to a vaccine against Buruli ulcer, a disfiguring and mutilating disease that causes a lot of suffering and now is difficult to treat. Several vaccine candidates work well in mice and are ready for further testing on blood of patients; one is ready for testing in mice.

19 Apr 2012

Gut microbiota plays a causal role in development of diabetes and NAFLD

Exciting new data presented today at the International Liver Congress 2012 shows the gut microbiota's causal role in the development of diabetes and non-alcoholic fatty liver disease (NAFLD), independent of obesity.

19 Apr 2012