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Researchers define nine molecular hallmarks of aging, debunk myths related to antioxidants

For some species, living twice as long in good health depends on no more than a few genes. When this fact was revealed by studies on worms three decades ago, it ushered in a golden age of ageing studies that has delivered numerous results, but also sown some confusion.

7 Jun 2013

Low levels of vitamin D associated with high levels of hepatitis B virus replication

Researchers from Germany have found that low levels of vitamin D are associated with high levels of hepatitis B virus replication. Findings published online in Hepatology, a journal of the American Association for the Study of Liver Diseases, suggest seasonal fluctuations in vitamin D and HBV levels point to a link in these variables among patients with chronic HBV.

6 Jun 2013

Changes in normal glycan behavior lead to fatal lysosomal disease, say researchers

From the neurons that enable thought to the keratinocytes that make toenails grow-a complex canopy of sugar molecules, commonly known as glycans, envelop every living cell in the human body.

6 Jun 2013

New technique for developing complex protein drugs from bacteria

A cheaper, more efficient technique for developing complex protein drugs from bacteria has been developed at the University of Sheffield.

6 Jun 2013

Research reveals how HIV triggers signal to kill infected immune cell

Untreated HIV infection destroys a person's immune system by killing infection-fighting cells, but precisely when and how HIV wreaks this destruction has been a mystery until now. New research by scientists at the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, reveals how HIV triggers a signal telling an infected immune cell to die.

6 Jun 2013

Cry proteins in Bacillus thuringiensis is lethal to Anopheles gambiae, the principal mosquito vector of malaria

Researchers at The University of Texas at Dallas (UTD), led by Dr. Lee Bulla, have characterized a protein produced by the soil bacterium Bacillus thuringiensis subsp. israelensis (Bti), which is highly toxic against Anopheles gambiae, the principal mosquito vector of malaria.

6 Jun 2013

Consumption of cheese and other dairy products may help protect teeth against cavities

Consuming dairy products is vital to maintaining good overall health, and it's especially important to bone health. But there has been little research about how dairy products affect oral health in particular.

6 Jun 2013

Researchers discover TRF1 gene that is important for nuclear reprogramming

Researchers are still fascinated by the idea of the possibility of reprogramming the cells of any tissue, turning them into cells with the capacity to differentiate into cells of a completely different type- pluripotent cells-and they are still striving to understand how it happens.

6 Jun 2013

Medicago reports positive interim results from preclinical trial for H7 VLP vaccine candidate

Medicago Inc., a biopharmaceutical company focused on developing highly effective and competitive vaccines based on proprietary manufacturing technologies and Virus-Like Particles, today reported positive interim results from a preclinical trial for an H7N9 Avian Influenza VLP vaccine candidate ("H7 vaccine").

6 Jun 2013

Findings have implications for potential gene therapies for autism spectrum disorders

A gene linked to autism spectrum disorders that was manipulated in two lines of transgenic mice produced mature adults with irreversible deficits affecting either learning or social interaction.

6 Jun 2013

Genetic duplication that occurred millions of years ago encouraged evolution of ASF1b gene: Study

How and when evolution generates diversity or gives form to proteins, living beings' functional building blocks, are essential questions that still surround the theory of evolution. In humans, the majority of genes have emerged via genetic duplication, a strategy in which a gene generates two identical copies that can evolve to generate different proteins.

6 Jun 2013

Investigators report possible missing link necessary to prevent osteoporosis

By analyzing biopsy specimens from patients with postmenopausal osteoporosis and primary hyperparathyroidism, investigators have begun to pay increasing attention to "reversal cells," which prepare for bone formation during bone remodeling.

6 Jun 2013

Scientists suggest that Oprl1 receptor is altered in mice with PTSD-like symptoms

When injected into mice immediately following a traumatic event, a new drug prevents the animals from developing memory problems and increased anxiety that are indicative of post-traumatic stress disorder.

6 Jun 2013

Researchers provide insights into potential therapeutic approaches to Down syndrome

University of Michigan researchers have determined how a gene that is known to be defective in Down syndrome is regulated and how its dysregulation may lead to neurological defects, providing insights into potential therapeutic approaches to an aspect of the syndrome.

6 Jun 2013

BUSM researchers uncover important clues that may expand treatment options for schizophrenia

Researchers at Boston University School of Medicine have uncovered important clues about a biochemical pathway in the brain that may one day expand treatment options for schizophrenia.

6 Jun 2013

Research shows link between formula-feeding and higher risk for chronic diseases later in life

New evidence from research suggests that infants fed formula, rather than breast milk, experience metabolic stress that could play a part in the long-recognized link between formula-feeding and an increased risk of obesity, type 2 diabetes and other conditions in adult life.

6 Jun 2013

Scientists develop first dual-action drug against melanoma skin cancer cells

Scientists are reporting development and successful lab tests on the first potential drug to pack a lethal one-two punch against melanoma skin cancer cells. Hit number one destroys cells in the main tumor, and the second hit blocks the spread of the cancer to other sites in the body, according to their report in the journal ACS Chemical Biology.

6 Jun 2013

New research suggests that surgical anesthesia may also have lasting effects on adult brains

As pediatric specialists become increasingly aware that surgical anesthesia may have lasting effects on the developing brains of young children, new research suggests the threat may also apply to adult brains.

6 Jun 2013

Scientists discover protective role of retinoic acid against intestinal inflammation

Scientists at Trinity College Dublin have made novel discoveries around the protective influence of Vitamin A against the damaging immune responses that lead to inflammatory bowel disease.

5 Jun 2013

Cells with amplified HER2 gene need to be considered carefully, study says

Biocept, Inc., a privately-held, CLIA certified laboratory testing company focused on detection and analysis of circulating tumor cells and circulating tumor DNA in cancer patients, reported the publication in the journal Cancer Medicine of a paper entitled "Discordance in HER2 gene amplification in circulating and disseminated tumor cells in patients with operable breast cancer" on research performed with collaborators from the University of Texas MD Anderson Cancer Center.

5 Jun 2013

Medical Science News

Researchers define nine molecular hallmarks of aging, debunk myths related to antioxidants

Low levels of vitamin D associated with high levels of hepatitis B virus replication

Changes in normal glycan behavior lead to fatal lysosomal disease, say researchers

New technique for developing complex protein drugs from bacteria

Research reveals how HIV triggers signal to kill infected immune cell

Cry proteins in Bacillus thuringiensis is lethal to Anopheles gambiae, the principal mosquito vector of malaria

Consumption of cheese and other dairy products may help protect teeth against cavities

Researchers discover TRF1 gene that is important for nuclear reprogramming

Medicago reports positive interim results from preclinical trial for H7 VLP vaccine candidate

Findings have implications for potential gene therapies for autism spectrum disorders

Genetic duplication that occurred millions of years ago encouraged evolution of ASF1b gene: Study

Investigators report possible missing link necessary to prevent osteoporosis

Scientists suggest that Oprl1 receptor is altered in mice with PTSD-like symptoms

Researchers provide insights into potential therapeutic approaches to Down syndrome

BUSM researchers uncover important clues that may expand treatment options for schizophrenia

Research shows link between formula-feeding and higher risk for chronic diseases later in life

Scientists develop first dual-action drug against melanoma skin cancer cells

New research suggests that surgical anesthesia may also have lasting effects on adult brains

Scientists discover protective role of retinoic acid against intestinal inflammation

Cells with amplified HER2 gene need to be considered carefully, study says

Building Bridges to Scalable Allogeneic Cell Therapy

Edoardo Fabini

Reducing polypharmacy through innovative drug formulation technologies

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