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New tool helps predict CAR T therapy outcomes for lymphoma patients

Researchers with City of Hope, one of the largest and most advanced cancer research and treatment organizations in the United States, with its National Medical Center in Los Angeles ranked among the nation's top 5 cancer centers by U.S. News & World Report, and MSK have created a tool that uses machine learning to assess a non-Hodgkin lymphoma (NHL) patient's likely response to chimeric antigen receptor (CAR) T cell therapy before starting the treatment, according to study results published today in Nature Medicine.

1 Apr 2025

WINREVAIR™ (sotatercept-csrk) reduced the risk of a composite of all-cause death, lung transplantation and hospitalization for pulmonary arterial hypertension (PAH) by 76% compared to placebo in the phase 3 ZENITH trial

Merck, known as MSD outside of the United States and Canada, today announced the first presentation of results from the Phase 3 ZENITH trial evaluating WINREVAIR™ (sotatercept-csrk) compared to placebo in adults with pulmonary arterial hypertension (PAH, Group 1 PH) WHO* functional class (FC) III or IV at high risk of mortality who were on maximum tolerated background PAH therapy. At a median follow-up of 10.6 months (range, 0.3-26.1), WINREVAIR reduced the relative risk of major morbidity and mortality events (the composite of all-cause death, lung transplantation and PAH worsening-related hospitalization of ≥24 hours) by 76% (HR=0.24 [95% CI, 0.13-0.43]; p<0.0001 [1-sided]) compared to placebo.

1 Apr 2025

A new blood test could improve how Alzheimer’s disease is diagnosed

The blood test for eMTBR-tau243 shows strong correlation with tau pathology, enhancing Alzheimer's diagnosis and monitoring cognitive decline effectively.

1 Apr 2025

Vitamin D monitoring during pregnancy and postpartum

Researchers determine the impact of vitamin D levels during pregnancy and their role in maternal and infant health outcomes.

1 Apr 2025

Scientists discover key genes for regenerating cells in the ear and eye

The same genes could hold the key to regenerating cells in the ear and eye, according to a new mouse study from the USC Stem Cell laboratory of Ksenia Gnedeva, PhD, published in the Proceedings of the National Academy of Sciences (PNAS).

1 Apr 2025

Queen Mary scientists invent a new way to repair osteochondral defects

Scientists at Queen Mary University of London have invented a new way to repair osteochondral defects – a common form of joint damage often caused by sports injuries or trauma – and to prevent progression to osteoarthritis.

1 Apr 2025

World first as MHRA approves trofolastat for diagnostic imaging of prostate cancer in men

The Medicines and Healthcare products Regulatory Agency (MHRA) has approved trofolastat (RoTecPSMA), the first prostate-specific membrane antigen (PSMA)-targeting product authorised for use with technetium-99m to detect cancerous lesions in men with prostate cancer.

31 Mar 2025

Researchers receive $2.7 million NIH grant to develop the next generation of synthetic blood

Blood loss is the leading cause of death in trauma patients between the ages of 1 and 46 years, largely because they cannot access safe blood sources quickly enough. A possible solution? Freeze-dried synthetic blood.

31 Mar 2025

Long-term Transcendental Meditation shown to improve stress and aging markers

A collaborative study conducted by researchers at Maharishi International University (MIU), the University of Siegen, and the Uniformed Services University of the Health Sciences reveals that individuals practicing Transcendental Meditation (TM) technologies long-term show favorable biological markers of aging and stress.

31 Mar 2025

Study helps characterize how sleep deficiency may relate to Alzheimer's pathogenesis

New research reveals that lower proportions of specific sleep stages are associated with reduced brain volume in regions vulnerable to the development of Alzheimer's disease over time.

31 Mar 2025

Research challenges traditional oxygen practices in trauma care

When a critically injured patient is admitted to the hospital, how much supplemental oxygen should they receive? New research published this week in JAMA Network Open led by investigators at the University of Colorado School of Medicine suggests it's often less than the current standard.

31 Mar 2025

Study reveals most plant-based milks don’t meet toddlers’ nutrient needs

Replacing cow’s milk with most plant-based drinks cuts key nutrients in young children’s diets unless products are fortified. Specially formulated soy drinks can maintain or even boost intakes of iron and iodine.

31 Mar 2025

What blueberries do and don’t do for your microbiome and heart

Regular blueberry consumption for 12 weeks enriched Coriobacteriales incertae sedis in the gut microbiota of older overweight adults. However, this microbial shift was not linked to significant improvements in cardiometabolic biomarkers.

31 Mar 2025

Defibrillators and CPR cut marathon cardiac deaths in half, study shows

Researchers found that while the rate of cardiac arrests during U.S. marathons and half-marathons remained stable from 2010 to 2023, the likelihood of death from these events dropped by nearly half—thanks to faster emergency response and widespread use of defibrillators.

31 Mar 2025

Five lifestyle changes by 50 can add a decade to your life, global study finds

Study estimates the global lifetime risk and benefits of modifying cardiovascular risk factors like hypertension, smoking, and obesity by age 50, showing significant improvements in both life expectancy and quality of life. It highlights the importance of early intervention and midlife changes in preventing cardiovascular disease and mortality.

31 Mar 2025

Blood test offers insight into Alzheimer's stage and severity

A newly developed blood test for Alzheimer's disease not only aids in the diagnosis of the neurodegenerative condition but also indicates how far it has progressed, according to a study by researchers at Washington University School of Medicine in St. Louis and Lund University in Sweden.

31 Mar 2025