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New research reveals why fiber-rich diets fuel you better than refined foods

This study quantifies how much energy the human body harvests from gut microbial fermentation of dietary fiber, integrating bacterial physiology, diet, and metagenomic data. Results reveal that dietary fiber, not microbiome composition, mainly determines the amount of short-chain fatty acids absorbed, impacting daily energy and metabolic health.

31 Jul 2025

Virtual memory T cells provide nonspecific immunity for infants early in life

Findings from St. Jude Children's Research Hospital demonstrate that virtual memory T cells, a specialized group of immune cells, provide nonspecific immunity for infants early in life.

31 Jul 2025

Selective impairment of translation contributes to brain aging in killifish

Aging selectively impairs the production of crucial DNA- and RNA-binding proteins, which contributes to hallmarks of aging in the brains of killifish, according to a new study.

31 Jul 2025

Behavioral adaptation precedes morphological change in human evolution

As early humans spread from lush African forests into grasslands, their need for ready sources of energy led them to develop a taste for grassy plants, especially grains and the starchy plant tissue hidden underground.

31 Jul 2025

Saliva testing offers a non-invasive way to detect early metabolic risk

Measuring elevated levels of insulin in blood, called hyperinsulinemia, is a proven way to measure metabolic health and can show risk of developing future health concerns, including Type 2 diabetes, obesity and heart disease.

31 Jul 2025

Understanding how the brain distinguishes between stuff and things

Imagine a ball bouncing down a flight of stairs. Now think about a cascade of water flowing down those same stairs.

31 Jul 2025

Advancing osteochondral regeneration through biomaterial-based drug delivery systems

Announcing a new article publication for BIO Integration journal. Osteochondral damage is primarily caused by degeneration of articular cartilage due to trauma, degenerative injury.

31 Jul 2025

Artificial sweetener may undermine effectiveness of cancer treatment

Sucralose is a popular sugar substitute for people who are cutting calories or managing blood sugar levels, but new research by the University of Pittsburgh and UPMC Hillman Cancer Center suggests that the artificial sweetener may not be the best choice for patients undergoing cancer immunotherapy.

31 Jul 2025

Rethinking prostate cancer risk in GG1 diagnoses

A new study reveals that some men who are diagnosed with "Grade Group one" (GG1) prostate cancer may actually be at higher risk than biopsy results suggest, according to research led by Weill Cornell Medicine, University Hospitals Cleveland and Case Western University.

31 Jul 2025

New blood test detects early-stage solid tumors with high accuracy

Current methods for cancer diagnosis are based on identifying biomarkers - molecules that reveal a particular state or process in the body – produced by the tumor or associated proteins.

31 Jul 2025

Gut bacteria produce hormone-like proteins that regulate weight and blood sugar

Our intestines are home to trillions of microorganisms that produce substances capable of regulating all the body's organs via the bloodstream and the gut's nervous system.

31 Jul 2025

T cell senescence shapes cancer prognosis and immunotherapy response

T cell senescence occurs in the TME, affecting cancer prognosis and immunotherapy efficacy. The TME induces T cell senescence through multiple pathways, including persistent stimulation by tumor-associated antigens, metabolic pathway alterations, activation of chronic inflammatory responses, proliferation of immunosuppressive cells, and T cell damage caused by tumor radiotherapy and chemotherapy.

31 Jul 2025

Cancer-associated fibroblasts exhibit paradoxical effects on immunotherapy

Cancer-associated fibroblasts (CAFs) – critical but enigmatic players in tumors – exhibit "paradoxical" effects on immunotherapy, according to a new review in Clinical and Translational Discovery.

31 Jul 2025

AI uncovers new lipid-lowering effects in existing FDA-approved drugs

In a breakthrough for cardiovascular medicine, researchers have harnessed artificial intelligence to discover unexpected lipid-lowering effects in existing FDA-approved drugs.

31 Jul 2025

Scarred liver tissue creates fertile ground for cancer development

Over 80% of hepatocellular carcinoma (HCC) – the third-leading cause of cancer deaths globally – emerges from advanced liver fibrosis or cirrhosis. A comprehensive review in Hepatology International synthesizes decades of research to reveal how scarred liver tissue becomes a breeding ground for cancer.

31 Jul 2025

Metformin lowers blood sugar by acting on brain pathways

Although metformin has been the go-to medication to manage type 2 diabetes for more than 60 years, researchers still do not have a complete picture of how it works.

31 Jul 2025

Black Death victims offer clues to childhood malnutrition and adult disease

The Black Death arrived on the shores of England in May 1348 and, in less than two years, spread throughout the country, killing an estimated 2 million people.

31 Jul 2025

Promising treatment slows liver cancer by inhibiting fat enzyme

Liver cancer cells thrive on fat, posing a serious risk of cancer diagnosis for millions of people living with fatty liver disease.

31 Jul 2025

Can stacking creatine and β-alanine give you extra gains? Here’s what science says

Co-supplementation with creatine and β-alanine may enhance high-intensity exercise performance, especially in repeated short bursts. However, it offers no additional benefit over creatine alone for maximal strength, aerobic capacity, or body composition.

30 Jul 2025

Why Spirulina could be a helpful natural option for lowering blood pressure

A comprehensive meta-analysis found that consuming whole microalgae, especially Spirulina, can significantly lower blood pressure, particularly in adults with elevated levels. No significant effects were observed for macroalgae or algae extracts.

30 Jul 2025