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Impairments in immune response contribute to severe COVID-19

New research by a team of scientists at University Hospital RWTH Aachen in Germany and Erasmus Medical Centre in The Netherlands characterized changes in CD8+ T cells in response to SARS-CoV-2.

8 Mar 2021

FDA-approved drug has limited treatment efficacy for hypoactive sexual desire disorder

An independent analysis of the medical trials which formed the final basis of approval by the US Food and Drug Administration (FDA) strongly suggests the drug bremelanotide has very limited effectiveness as a treatment for hypoactive sexual desire disorder (HSDD) in women, and that trial participants preferred a placebo.

8 Mar 2021

New system to automatically extract adverse drug reactions from electronic health records

Patients' electronic health records convey crucial information. The application of natural language processing techniques to these records may be an effective means of extracting information that may improve clinical decision making, clinical documentation and billing, disease prediction and the detection of adverse drug reactions.

5 Mar 2021

New approach using virtual clinical trials could revolutionize drug development

New cutting-edge research undertaken at the University of Leicester could revolutionize the way new drugs are developed and the way patients are cared for, through a pioneering new approach using virtual clinical trials

5 Mar 2021

SARS-CoV-2 proteins are potent suppressors of innate immunity

A new study describes the strong immune-suppressing activity of SARS-CoV-2 genes, among other coronavirus genes.

5 Mar 2021

IQWiG's new threshold proven feasible in practice for early benefit assessments of drugs

Current examples prove the feasibility of the 15 percent threshold newly defined by IQWiG for the acceptance of responder analyses in early benefit assessments of drugs.

5 Mar 2021

Novavax COVID-19 vaccine shows efficacy against South African SARS-CoV-2 variant

Researchers in the United States and South Africa report that the NVX-CoV2373 vaccine from Novavax has proved effective at preventing coronavirus disease (COVID-19) caused by the B.1.351 variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has recently emerged in South Africa.

4 Mar 2021

AI-based method for repurposing existing drugs into potential treatments for Alzheimer's

New treatments for Alzheimer's disease are desperately needed, but numerous clinical trials of investigational drugs have failed to generate promising options.

4 Mar 2021

Researchers show potential benefits of delaying second mRNA COVID-19 vaccine dose

The currently approved mRNA vaccines from Moderna and Pfizer-BioNTech help create neutralizing antibodies against the SARS-CoV-2 spike protein. Both companies designed their vaccines to be delivered in two doses. However, given the limited supply of vaccines worldwide, a new modeling study has suggested that vaccinating more people with the first dose and delaying the second could be an alternate route to achieving population immunity that could reduce mortality rates.

4 Mar 2021

Mask wearing, physical distancing can prevent spikes in COVID-19 cases during vaccine distribution

Research out on the pre-publication website medRxiv shows how non-pharmaceutical interventions (NPIs) like mask wearing and physical distancing can help prevent spikes in COVID-19 cases as populations continue to get vaccinated.

4 Mar 2021

Study examines the variability in opioid prescriptions for common orthopedic procedures

A new review article published in the March issue of the Journal of the American Academy of Orthopaedic Surgeons (JAAOS) examines the variability that exists in opioid prescribing patterns across the United States for many common orthopedic procedures.

4 Mar 2021

Researchers call for more awareness relating to delayed skin reactions to Moderna COVID-19 vaccine

As the speed and scale of vaccinations against the SARS-CoV-2 virus ramps up globally, researchers at Massachusetts General Hospital (MGH) are calling for greater awareness and communication around a delayed injection-site reaction that can occur in some patients who have received the Moderna mRNA-1273 vaccine.

3 Mar 2021

Results from phase 2 trial of Novavax recombinant nanoparticle SARS-CoV-2 vaccine

Novavax, Inc., the American vaccine development company, has been developing a recombinant protein nanoparticle COVID-19 vaccine currently termed NVX-CoV2373. The full-length spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is created in a baculovirus vector, which is then inserted into a lipid nanoparticle around 50 nm in diameter.

3 Mar 2021

UK public health authorities review early data on the effectiveness of Pfizer and AstraZeneca COVID-19 vaccines

A team of UK scientists has recently evaluated the effectiveness of the Pfizer (BNT162b2) and AstraZeneca (ChAdOx1) vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The findings reveal that both vaccines are effective in significantly reducing SARS-CoV-2 infection in older adults and providing long-term protection.

3 Mar 2021

Pharmaceutical News

Impairments in immune response contribute to severe COVID-19

FDA-approved drug has limited treatment efficacy for hypoactive sexual desire disorder

New system to automatically extract adverse drug reactions from electronic health records

New approach using virtual clinical trials could revolutionize drug development

SARS-CoV-2 proteins are potent suppressors of innate immunity

IQWiG's new threshold proven feasible in practice for early benefit assessments of drugs

Novavax COVID-19 vaccine shows efficacy against South African SARS-CoV-2 variant

AI-based method for repurposing existing drugs into potential treatments for Alzheimer's

Researchers show potential benefits of delaying second mRNA COVID-19 vaccine dose

Mask wearing, physical distancing can prevent spikes in COVID-19 cases during vaccine distribution

Study examines the variability in opioid prescriptions for common orthopedic procedures

Researchers call for more awareness relating to delayed skin reactions to Moderna COVID-19 vaccine

Results from phase 2 trial of Novavax recombinant nanoparticle SARS-CoV-2 vaccine

UK public health authorities review early data on the effectiveness of Pfizer and AstraZeneca COVID-19 vaccines

Obesity may reduce COVID-19 vaccine efficacy, say researchers

Delayed second dose strategy with mRNA vaccines may reduce COVID-19 mortality, say researchers

Semaglutide drug also helps diabetic patients lose body weight, shows study

Placebo-like effects may explain the benefits of psychedelic drugs

Study provides detailed insight into neural mechanisms underlying placebo effects

Moderna vaccine reduces viral spread by at least 60 percent, finds study

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