Chronic Fatigue Syndrome

Chronic Fatigue Syndrome is a condition lasting for more than 6 months in which a person feels tired most of the time and may have trouble concentrating and carrying out daily activities. Other symptoms include sore throat, fever, muscle weakness, headache, and joint pain. Also called CFS.

What is Chronic Fatigue Syndrome?

Chronic fatigue syndrome is a condition that leads to symptoms of persistent fatigue that do not resolve after rest or sleep.

Chronic Fatigue Syndrome History

Chronic Fatigue Syndrome Society and Culture

Chronic Fatigue Syndrome Symptoms

Chronic Fatigue Syndrome Pathophysiology

Chronic Fatigue Syndrome Prognosis

Chronic Fatigue Syndrome Epidemiology

Chronic Fatigue Syndrome Treatment

Fibromyalgia and Chronic Fatigue Syndrome: Similarities and Differences

Chronic Fatigue Syndrome Classification

Chronic Fatigue Syndrome Naming

Latest Chronic Fatigue Syndrome News and Research

New diagnostic code brings recognition and support for Gulf War Illness

Gulf War illness (GWI), the chronic, debilitating condition linked to military service in the 1990-1991 Gulf War, will receive a dedicated diagnostic code in the October 2025 release of the International Classification of Diseases (ICD-10-CM).

11 Sep 2025

Experts review the evidence on coenzyme Q10 and cognitive decline

Researchers reviewed evidence on coenzyme Q10 (CoQ10) and cognition, finding strong biological support and positive results in animal models but mixed outcomes in human trials. Larger, high-quality studies are needed to clarify whether CoQ10 can protect against cognitive decline and neurodegenerative diseases.

9 Sep 2025

Hidden protein particle in COVID virus may lead to longer-lasting vaccines

A protein particle hidden within the SARS-CoV-2 virus could lead to longer-lasting, more protective vaccines for COVID-19.

4 Sep 2025

Research reveals molecular details of ME/CFS and long COVID

Patients with chronic fatigue syndrome/myalgic encephalomyelitis (ME/CFS) have heightened innate immune responses to bacteria, viruses, and fungi. While these responses are essential to fight infection, they can cause damage when unchecked.

1 Sep 2025

Researchers develop machine learning models to identify biomarkers for chronic fatigue syndrome

When cells expire, they leave behind an activity log of sorts: RNA expelled into blood plasma that reveal changes in gene expression, cellular signaling, tissue injury and other biological processes.

11 Aug 2025

Unraveling the mysteries of post-acute infection syndromes

In recent years, doctors and scientists are increasingly studying long-lasting illnesses that begin after someone recovers from an infection.

1 Aug 2025

Research uncovers ME/CFS's systemic impact for targeted therapies

Millions suffering from myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a debilitating condition often overlooked due to the lack of diagnostic tools, may be closer to personalized care, according to new research that shows how the disease disrupts interactions between the microbiome, immune system, and metabolism.

26 Jul 2025

Blood filtration may offer new hope for removing microplastics from the body

Researchers report the first evidence that therapeutic apheresis, a blood-filtration technique, can remove microplastic- and nanoplastic-like particles from humans with ME/CFS. While promising, further studies are needed to quantify removal and assess clinical benefits.

21 May 2025

Seeking spending cuts, GOP lawmakers target a tax hospitals love to pay

On the eastern plains of Colorado, in a county of less than 6,000 people, Lincoln Health runs the only hospital within a 75-minute drive. The facility struggles financially, given its small size and the area's tiny population.

8 May 2025

Research reveals significant increase in ME/CFS cases across England

There are almost two-thirds more people living with ME/CFS in England than previously thought, a study says.

22 Apr 2025

Macrophages use bacteria to build vital nutrients and control inflammation

Immune cells that eat bacteria in the body don't stash them in specialized compartments as once thought, but turn them into critical nutrients that build proteins, create energy and keep the cells alive, according to a new study from scientists at the University of Colorado Anschutz Medical Campus.

27 Feb 2025

Colorado study tracks long COVID healthcare utilization

A new study analyzing Long COVID healthcare utilization in Colorado reveals a significant shift from acute care to outpatient services following diagnosis, shedding light on evolving treatment patterns and the broader healthcare burden posed by the condition.

11 Feb 2025

Long-covid patients are frustrated that federal research hasn’t found new treatments

Erica Hayes, 40, has not felt healthy since November 2020 when she first fell ill with covid.

22 Jan 2025

COVID-19 dramatically raises the risk of developing ME/CFS

Study highlights a fourfold increase in ME/CFS risk among COVID-19 patients, with 89% of post-COVID ME/CFS cases overlapping with severe long COVID symptom clusters.

16 Jan 2025

COVID-19 infection linked to increased cases of ME/CFS

New findings from the National Institutes of Health's (NIH) Researching COVID to Enhance Recovery (RECOVER) Initiative suggest that infection with SARS-CoV-2, the virus that causes COVID-19, may be associated with an increase in the number of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) cases.

13 Jan 2025

Study finds T cell exhaustion in chronic fatigue syndrome patients

Chronic fatigue syndrome creates conditions where pathogen-killing immune T cells become exhausted, according to a new Cornell University study.

3 Dec 2024

Researchers seek to develop noninvasive diagnostics for chronic fatigue syndrome

Chronic fatigue syndrome (CFS) is a complex and long-term illness characterized by extreme fatigue that doesn't improve with rest, and can worsen with physical activity.

21 Nov 2024

Wearable sensors and machine learning predict worker fatigue to improve safety and productivity

Researchers used multimodal wearable sensors and machine learning to track real-time fatigue in manufacturing workers, revealing critical insights into individual fatigue patterns and potential ergonomic improvements.

22 Oct 2024

Mount Sinai launches new center for complex chronic illnesses

Mount Sinai's Department of Rehabilitation and Human Performance has announced the grand opening of the Cohen Center for Recovery From Complex Chronic Illnesses (CoRE), providing clinical care for patients with conditions such as long Lyme disease/Lyme+, long COVID, and other infection-associated complex chronic illnesses such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Ehlers-Danlos syndrome (EDS).

10 Oct 2024

COVID-19 increases chronic fatigue risk

Study reveals that COVID-19 significantly increases the risk of chronic fatigue syndrome, with specific populations, such as older adults, Asians, and non-hospitalized patients, at higher risk.

7 Oct 2024