Dendritic Cell News and Research

Latest Dendritic Cell News and Research

Dendritic cells tricked into action against cancer

A new type of immunotherapy in which dendritic cells are tricked into action against cancer when they are exposed to harmless pieces of viruses and bacteria is described in the November issue of Cancer Research.

1 Nov 2005

Reagent under study as cancer vaccine may also help protect tumors

A bacterial mimic under study as a cancer vaccine because it signals the immune system to attack may also help some tumors hide, researchers have found.

1 Nov 2005

Identification of a factor in human milk that can block HIV-1 transmission

Mother to child transmission of HIV accounts for a large proportion of HIV infections in children, with many infected as a result of breastfeeding, which requires transfer of the virus across mucosal barriers. DC-SIGN, a DC lectin receptor, interacts with HIV and is found at high expression levels in tonsillar tissue.

20 Oct 2005

Endocytosis of HIV-1 activates plasmacytoid dendritic cells via toll-like receptor -viral RNA interactions

Progressive disease after HIV infection is inversely correlated with the presence of plasmacytoid dendritic cells (pDCs), a subset of the dendritic cell family and the major producers of type 1 interferon in the body. High numbers of pDCs is related to successful control of HIV.

13 Oct 2005

New discoveries help explore the function of regulatory T cells in autoimmune disease and in cancer

More than 150 years after the discovery of Hassall's corpuscles in 1849, the function of these round blobs of cells in the human thymus gland has now been explained. The answer, in turn, ends an intense hunt for the origin of regulatory T cells that has been under way for years.

11 Oct 2005

Real dangers from environmental toxins most likely occur early in life

Exposure of developing fetuses and newborns to low levels of environmental toxins such as lead, mercury and dioxin, as well as nicotine and ethanol, could be behind the recent sharp rises in asthma, allergies and autoimmune disorders like lupus, says a Cornell University researcher.

10 Oct 2005

Compounds secreted by frog skin are potent blockers of HIV infection

The findings could lead to topical treatments for preventing HIV transmission, and they reinforce the value of preserving the Earth's biodiversity.

3 Oct 2005

Cancer vaccine based on the bacterium Listeria monocytogenes, can cure mice with breast tumors

A team from the University of Pennsylvania School of Medicine has shown that by using a cancer vaccine based on the bacterium Listeria monocytogenes, they can cure mice with established breast tumors. Cancer vaccines, which are more properly described as immunotherapy, work by boosting an immune response against tumor-associated antigens.

27 Sep 2005

Surprising immune system cells discovery

Immune system cells are connected to each other by an extensive network of tiny tunnels that, like a building's hidden pneumatic tube system, are used to shoot signals to distant cells.

26 Sep 2005

Polymorphisms in a receptor called CD32 influence the response to antibody therapy in cancer

In a paper appearing online in advance of print publication of the October 1 issue of the Journal of Clinical Investigation, Adam Boruchov and colleagues from Memorial Sloan Kettering Cancer Center dissect the contributions of CD32 isoforms in human dendritic cell (DC) activation and function.

26 Sep 2005

Screening test for cells that activate immune system

UT Southwestern Medical Center researchers are the first to create a large-scale, cell-based screening method that identifies which compounds activate immune-response cells that hold promise for future cancer-fighting vaccines.

12 Sep 2005

Researchers develop screening test for cells that activate immune system

7 Sep 2005

Profile of immune cells in axillary lymph nodes predicts disease-free survival in breast cancer

Breast cancer often spreads through the lymph nodes in the arm pits (so-called axillary lymph nodes), and whether these lymph nodes are tumor-free or contain small metastases is an important factor in the decision of how aggressively to treat a patient.

6 Sep 2005

New way to assess risk of breast cancer recurrence

Currently, the best way to predict whether a breast cancer is likely to recur is to determine whether tumor cells have invaded the lymph nodes near the breast.

5 Sep 2005

New vaccine protects more effectively against tuberculosis

Max Planck researchers have uncovered the mechanism by which the new genetically engineered tuberculosis vaccine functions.

28 Aug 2005

Protein snapin has potential as a drug target in therapies aimed at learning and memory disorders

Rutgers' Bonnie Firestein likens nerve cells to trees -- some are short and bushy with many branches while others are tall with a few branches coming out of one or two main trunks. Different branching patterns correlate with specific disorders and Firestein's quest is to discover how these dissimilar patterns come about and why.

25 Aug 2005

The role of antigenic drive and tumor-infiltrating accessory cells in the pathogenesis of Helicobacter-induced MALT lymphoma

Research led by Dr. Anne Mueller at Stanford University School of Medicine demonstrates that successful eradication of Helicobacter may not prevent future aggressive gastric lymphoma since resting B cells are left behind.

25 Aug 2005

Experimental vaccine can prime the immune system to help fight an aggressive form of lymphoma

Researchers at The University of Texas M. D. Anderson Cancer Center and the National Cancer Institute have found that an experimental vaccine can prime the immune system to help fight an aggressive form of lymphoma, even though prior therapy had eliminated virtually all of the B cells thought necessary to mount such a defense.

22 Aug 2005

Combined gene therapy eliminates glioblastoma multiforme in lab studies

Despite aggressive treatment, glioblastoma multiforme (GBM) - the most common and deadly of brain cancers - usually claims the lives of its victims within six to 12 months of diagnosis. Because GBM is so aggressive, the disease has been the target of a number of laboratory and clinical studies investigating the effectiveness of gene therapy to deliver novel therapies to the brain.

15 Aug 2005

Two studies reveal how plague disables immune system

Two studies by researchers at the University of Chicago show how the bacteria that cause the plague manage to outsmart the immune system and how, by slightly altering one of the microbe's tools, the researchers produced what may be the first safe and effective vaccine.

1 Aug 2005

Dendritic Cell News and Research

Latest Dendritic Cell News and Research

Dendritic cells tricked into action against cancer

Reagent under study as cancer vaccine may also help protect tumors

Identification of a factor in human milk that can block HIV-1 transmission

Endocytosis of HIV-1 activates plasmacytoid dendritic cells via toll-like receptor -viral RNA interactions

New discoveries help explore the function of regulatory T cells in autoimmune disease and in cancer

Real dangers from environmental toxins most likely occur early in life

Compounds secreted by frog skin are potent blockers of HIV infection

Cancer vaccine based on the bacterium Listeria monocytogenes, can cure mice with breast tumors

Surprising immune system cells discovery

Polymorphisms in a receptor called CD32 influence the response to antibody therapy in cancer

Screening test for cells that activate immune system

Researchers develop screening test for cells that activate immune system

Profile of immune cells in axillary lymph nodes predicts disease-free survival in breast cancer

New way to assess risk of breast cancer recurrence

New vaccine protects more effectively against tuberculosis

Protein snapin has potential as a drug target in therapies aimed at learning and memory disorders

The role of antigenic drive and tumor-infiltrating accessory cells in the pathogenesis of Helicobacter-induced MALT lymphoma

Experimental vaccine can prime the immune system to help fight an aggressive form of lymphoma

Combined gene therapy eliminates glioblastoma multiforme in lab studies

Two studies reveal how plague disables immune system

Immunology eBook

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

Dendritic Cell News and Research

Latest Dendritic Cell News and Research

Immunology eBook

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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