Dendritic Cell News and Research

Latest Dendritic Cell News and Research

New grant to Harvard Medical School is boosting efforts to understand and combat rare cancers

Curing cancer has been the dream of countless doctors and researchers over the decades. Yet some types of cancer, whether because they affect relatively few people or lack influential advocates, receive less attention and funding than others.

7 Apr 2021

Dual-antigen COVID-19 vaccine elicits humoral and cellular immune responses in mice

The scientific consensus is that safe and highly effective vaccines are required to end the ongoing pandemic of coronavirus disease 2019 COVID-19, caused by SARS-CoV-2. A new study describes a new vaccine that presents two viral antigens to the human immune system, in order to elicit a more efficacious response.

25 Mar 2021

SARS-CoV-2 can cause persistent dendritic cell deficiencies

In a new study, the persistent influence of SARS-CoV-2 on dendritic cell deficiency seven months post-infection is asserted, and the mechanism of action investigated.

24 Mar 2021

New study may lead to therapeutic strategies for chronic lung disease

Scientists at Washington University School of Medicine in St. Louis have implicated a type of immune cell in the development of chronic lung disease that sometimes is triggered following a respiratory viral infection.

10 Mar 2021

SARS-CoV-2 escapes host immune responses by modulating dendritic cell maturation

A team of scientists from Italy and the USA has recently explored the maturation pattern of conventional dendritic cells (cDCs) during SARS-CoV-2 infection.

5 Mar 2021

Cell surface marker CD47 may allow early diagnosis of severe COVID-19

A new study reports the potential of the cell surface marker, CD47, as a biomarker for hyperinflammation, a characteristic feature of severe COVID-19.

4 Mar 2021

Novel SARS-CoV-2 spike vaccine candidate produces strong neutralizing response in vivo

A new study by researchers at Mahidol University in Bangkok, Thailand, reports a COVID-19 vaccine candidate called HexaPro in producing neutralizing antibodies against the SARS-CoV-2 spike protein in an animal model.

3 Mar 2021

Glycan switch may explain why SARS-CoV-2 causes such variable symptoms

Researchers in Portugal have provided evidence that might explain why infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes mild or even asymptomatic illness in some individuals, but severe coronavirus disease 2019 (COVID-19) in others.

23 Feb 2021

Virus-specific cellular immunity may be essential for long-term protection against SARS-CoV-2

Researchers from China and the US recently synthesized select peptide pools of the structural and functional proteins of SARS-CoV-2, including spike (S), envelope (E), membrane (M), nucleocapsid (N), and protease (P) proteins as target antigens to assess COVID-19-specific immunity.

22 Feb 2021

Polyphenols may provide protective effect against COVID-19 disease

In the study published in the journal Integrative Physiology, the researchers found that a high intake of polyphenols may have a protective effect on patients with COVID-19 and prevent disease progression.

22 Feb 2021

Study shows how gut bacteria can dull the efficacy of radiotherapy

A study led by Ludwig Chicago Co-director Ralph Weichselbaum and Yang-Xin Fu of the University of Texas Southwestern Medical Center has shown how bacteria in the gut can dull the efficacy of radiotherapy, a treatment received by about half of all cancer patients.

26 Jan 2021

Combining anti-tumor antibodies with standard-of-care improves therapeutic outcomes in cancer

The cover for issue 2 of Oncotarget features Figure 4, "Combination therapy TA99/ICB reduced the lung tumor burden in the B16 model of metastases," published in "Improved therapeutic efficacy of unmodified anti-tumor antibodies by immune checkpoint blockade and kinase targeted therapy in mouse models of melanoma" by Pérez-Lorenzo, et al. which reported that here, the authors showed that removing immune suppression and enhancing stimulatory signals increased the anti-tumor activity of unmodified TA99 antibodies with a significant reduction of growth of solid tumors and lung metastases in mouse models of melanoma.

25 Jan 2021

Study reveals how the immune system detects signs of disease, activates a protective response

Researchers at the Francis Crick Institute have uncovered an important process in how our immune system detects signs of disease and activates a protective response. This understanding could improve efforts to find new and effective immunotherapy treatments for diseases like cancer.

22 Dec 2020

Novel antibody-drug conjugate shows 29% response rate in rare blood cancer

Early study data shows a 29% overall response rate, the favorable safety profile in blastic plasmacytoid dendritic cell neoplasm (BPDCN)

8 Dec 2020

Vitamin D3 supplementation shows no therapeutic benefits in severe COVID-19 patients, study finds

A team of researchers at the University of São Paulo in Brazil aimed to determine if vitamin D3 supplementation reduces the length of stay in hospitalized patients with severe COVID-19.

18 Nov 2020

Researchers use heparin to block co-receptor for SARS-CoV-2 infection

Researchers at the University of Amsterdam have conducted a study showing that heparan sulfate proteoglycans are important co-receptors that severe acute respiratory syndrome 2 (SARS-CoV-2) requires to infect host cells.

19 Aug 2020

China's Ad5 vectored COVID-19 vaccine safe and induces immune response

A phase 2 trial of an Ad5 vectored COVID-19 vaccine candidate, conducted in China, has found that the vaccine is safe and induces an immune response, according to new research published in The Lancet.

20 Jul 2020

Type 1 interferon deficiency as a biomarker for detecting patients at risk of severe COVID-19

Approximately 5% of people with Covid-19 progress to a severe or critical form, including the development of severe pneumonia that progresses to acute respiratory distress syndrome.

17 Jul 2020

Berkeley Lights announces Opto™ antigen-presenting bead kit to accelerate the expansion of antigen-specific T cells used to develop cell-based therapies

Berkeley Lights, Inc. today announced the Opto Antigen-Presenting Bead kit, a new reagent kit that activates and expands antigen-specific T cells in blood.

From Bruker Cellular Analysis 25 Jun 2020

Study reveals novel mechanism that triggers a cell-mediated immune response

Viruses and other disease-causing microbes influence the type of immune response their hosts will develop against them. In some cases, the predominant response involves antibodies, proteins made by the immune system that specifically recognize parts of the invading microbe and mediate its destruction.

11 Jun 2020

Dendritic Cell News and Research

Latest Dendritic Cell News and Research

New grant to Harvard Medical School is boosting efforts to understand and combat rare cancers

Dual-antigen COVID-19 vaccine elicits humoral and cellular immune responses in mice

SARS-CoV-2 can cause persistent dendritic cell deficiencies

New study may lead to therapeutic strategies for chronic lung disease

SARS-CoV-2 escapes host immune responses by modulating dendritic cell maturation

Cell surface marker CD47 may allow early diagnosis of severe COVID-19

Novel SARS-CoV-2 spike vaccine candidate produces strong neutralizing response in vivo

Glycan switch may explain why SARS-CoV-2 causes such variable symptoms

Virus-specific cellular immunity may be essential for long-term protection against SARS-CoV-2

Polyphenols may provide protective effect against COVID-19 disease

Study shows how gut bacteria can dull the efficacy of radiotherapy

Combining anti-tumor antibodies with standard-of-care improves therapeutic outcomes in cancer

Study reveals how the immune system detects signs of disease, activates a protective response

Novel antibody-drug conjugate shows 29% response rate in rare blood cancer

Vitamin D3 supplementation shows no therapeutic benefits in severe COVID-19 patients, study finds

Researchers use heparin to block co-receptor for SARS-CoV-2 infection

China's Ad5 vectored COVID-19 vaccine safe and induces immune response

Type 1 interferon deficiency as a biomarker for detecting patients at risk of severe COVID-19

Berkeley Lights announces Opto™ antigen-presenting bead kit to accelerate the expansion of antigen-specific T cells used to develop cell-based therapies

Study reveals novel mechanism that triggers a cell-mediated immune response

Immunology eBook

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

Dendritic Cell News and Research

Latest Dendritic Cell News and Research

Immunology eBook

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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