Dopamine News and Research

Latest Dopamine News and Research

Atypical antipsychotic shows bipolar I depression efficacy

The atypical antipsychotic cariprazine may be effective for the treatment of bipolar I depression, phase II study findings show.

20 Nov 2015

Interaction between two brain proteins has substantial effect on memory formation

In a new study that could have implications for future drug discovery efforts for a number of neurodegenerative diseases, scientists from the Florida campus of The Scripps Research Institute (TSRI) have found that the interaction between a pair of brain proteins has a substantial and previously unrecognized effect on memory formation.

20 Nov 2015

Testosterone cause of sex differences in the occurrence of Parkinson’s disease, new research suggests

Men are twice as likely as women to develop Parkinson's disease, a nervous system disorder characterized by tremors and difficulty moving. New research to be presented at Cardiovascular, Renal and Metabolic Diseases: Physiology and Gender suggests that the difference in risk may be due to the presence of the male sex hormone testosterone.

19 Nov 2015

Two genetic variants interact to alter the brain responses to high-calorie foods

For the first time, researchers have identified two genetic variants that interact to alter the brain responses to high-calorie foods, a tie that could aid in the development of targeted treatments for obesity and overweight. Researchers at Imperial College London led by Tony Goldstone, MD, PhD, of Consultant Endocrinologist, found that two gene variants - FTO and DRD2 - influenced activity in the brain reward system when looking at pictures of high-calorie foods.

6 Nov 2015

Unwanted formation of blood vessels in the brain may cause intractable difficulties for Parkinson's disease patients

Unwanted formation of blood vessels (angiogenesis) in the brain is likely to be the cause of intractable walking and balance difficulties for people who suffer from Parkinson's disease. This conclusion is supported by new research from Lund University in Sweden.

5 Nov 2015

PolyU researchers develop novel biosensor for measuring glucose level in saliva

Diabetic patients have to monitor blood glucose regularly and frequently, but conventional method of taking blood sample for measuring glucose level is painful. It is therefore important to develop high performance biological sensors for monitoring the glucose level at a reasonable cost.

3 Nov 2015

Insulin plays a much stronger role in regulating release of dopamine

Insulin, the hormone essential to all mammals for controlling blood sugar levels and a feeling of being full after eating, plays a much stronger role than previously known in regulating release of dopamine, a neurotransmitter that helps control the brain's reward and pleasure centers, new studies by researchers at NYU Langone Medical Center show.

27 Oct 2015

Researchers find that stem cell treatment may reduce cognitive impairment related to dementia with Lewy bodies

Neural stem cells transplanted into damaged brain sites in mice dramatically improved both motor and cognitive impairments associated with dementia with Lewy bodies, according to University of California, Irvine neurobiologists with the Sue & Bill Gross Stem Cell Research Center and the Institute for Memory Impairments and Neurological Disorders.

19 Oct 2015

Researchers one step closer to finding effective drug for alcohol dependence

Researchers at Karolinska Institutet and the Sahlgrenska Academy in Sweden might be one step closer to finding an effective drug for alcohol dependence. In two separate studies, they show that the so-called dopamine stabilizer OSU6162 can reduce the craving for alcohol in alcohol dependent people and normalises the level of dopamine in the brain reward system of rats that have consumed alcohol over a long period of time.

14 Oct 2015

Finnish researchers find that obesity surgery normalizes brain's opioid neurotransmission

Researchers at Aalto University and University of Turku have revealed how obesity surgery recovers opioid neurotransmission in the brain.

13 Oct 2015

SynAgile announces positive results from Phase 2a trial of continuous intraoral LD/CD therapy

SynAgile Corporation, a privately held pharmaceutical company that develops and commercializes drug delivery systems using its proprietary OraFuse intraoral technology platform, today announced positive results from a proof-of-concept, Phase 2a, open-label clinical trial of continuous intraoral administration of levodopa-carbidopa (LD/CD).

8 Oct 2015

Neurocrine Biosciences announces positive data from NBI-98854 Phase III trial in tardive dyskinesia

Neurocrine Biosciences, Inc. announced today that NBI-98854, a highly selective small molecule VMAT2 inhibitor, showed a statistically significant reduction in tardive dyskinesia during the six weeks of placebo-controlled treatment in the Kinect 3 clinical trial. This Phase III trial included moderate to severe tardive dyskinesia patients with underlying schizophrenia, schizoaffective disorder, bipolar or major depressive disorder.

8 Oct 2015

Controlling TH-containing neurons can manipulate maternal behavior of females and aggression of males

Most female mammals give birth and care for their offspring, while the males often breed with multiple partners and play little role in parenting once the mating is over. Yet researchers have had a hard time pinpointing where, exactly, in the brain these differences between the sexes are located and how they translate into behavior. The extent of "hardwired parental behavior" is hotly disputed.

8 Oct 2015

Dopamine transmission mediated by D1 receptors essential for controlling movements in Parkinson's disease

Dopamine deficiency in the basal ganglia (a set of subcortical structures) causes severe motor dysfunctions, such as slowness of movements (bradykinesia), as observed in Parkinson's disease. Dopamine binds D1 and D2 receptors that are expressed in the nerve cells of the striatum (a structure of the basal ganglia), and exerts different effects on the nerve cells. However, how dopamine controls through these receptors the information flow in the basal ganglia and voluntary movements is still not clear.

6 Oct 2015

New flame retardant created to replace commercial additives that are often toxic

Inspired by a naturally occurring material found in marine mussels, researchers at The University of Texas at Austin have created a new flame retardant to replace commercial additives that are often toxic and can accumulate over time in the environment and living animals, including humans.

6 Oct 2015

Type-2 diabetes medication can affect the brain's reward system, reduce intake of food

Many studies have focused on how much we eat when we are hungry, but sometimes we eat just to feel better. A new dissertation at Sahlgrenska Academy shows that medication used for type-2 diabetes wich mimics the gut-brain hormone glucagon-like peptide-1, can affect the brain's reward system and reduce the intake of food.

29 Sep 2015

Study: Increased acetylation of histones promotes fear extinction in mice

The targeted modulation of gene activity and cellular signaling pathways could provide a new approach to the treatment of fear and anxiety states according to the recent findings of a project sponsored by the Austrian Science Fund FWF.

29 Sep 2015

Medication used for diabetes could be a valuable tool for treating alcohol dependence

A new study on mice and rats at Sahlgrenska Academy shows that a medication used for diabetes and obesity also could be a valuable tool for the treatment of alcohol dependence.

25 Sep 2015

Neuroscientists reveal the brain malady responsible for tinnitus, chronic pain

Neuroscientists at Georgetown University Medical Center and Germany's Technische Universität München say they've uncovered the brain malady responsible for tinnitus and for chronic pain — the uncomfortable, sometimes agonizing sensations that persist long after an initial injury.

24 Sep 2015

Innovative detector could expand use of polarized light for drug screening, surveillance

Invention of the first integrated circularly polarized light detector on a silicon chip opens the door for development of small, portable sensors that could expand the use of polarized light for drug screening, surveillance, optical communications and quantum computing, among other potential applications.

23 Sep 2015

Dopamine News and Research

Latest Dopamine News and Research

Atypical antipsychotic shows bipolar I depression efficacy

Interaction between two brain proteins has substantial effect on memory formation

Testosterone cause of sex differences in the occurrence of Parkinson’s disease, new research suggests

Two genetic variants interact to alter the brain responses to high-calorie foods

Unwanted formation of blood vessels in the brain may cause intractable difficulties for Parkinson's disease patients

PolyU researchers develop novel biosensor for measuring glucose level in saliva

Insulin plays a much stronger role in regulating release of dopamine

Researchers find that stem cell treatment may reduce cognitive impairment related to dementia with Lewy bodies

Researchers one step closer to finding effective drug for alcohol dependence

Finnish researchers find that obesity surgery normalizes brain's opioid neurotransmission

SynAgile announces positive results from Phase 2a trial of continuous intraoral LD/CD therapy

Neurocrine Biosciences announces positive data from NBI-98854 Phase III trial in tardive dyskinesia

Controlling TH-containing neurons can manipulate maternal behavior of females and aggression of males

Dopamine transmission mediated by D1 receptors essential for controlling movements in Parkinson's disease

New flame retardant created to replace commercial additives that are often toxic

Type-2 diabetes medication can affect the brain's reward system, reduce intake of food

Study: Increased acetylation of histones promotes fear extinction in mice

Medication used for diabetes could be a valuable tool for treating alcohol dependence

Neuroscientists reveal the brain malady responsible for tinnitus, chronic pain

Innovative detector could expand use of polarized light for drug screening, surveillance

How the Vutara VXL simplifies single-molecule imaging

How cohesin mechanics and nanotracker tech are redefining DNA research

Todd Bauman and Chris Povich

Dopamine News and Research

Latest Dopamine News and Research

How the Vutara VXL simplifies single-molecule imaging

How cohesin mechanics and nanotracker tech are redefining DNA research

Todd Bauman and Chris Povich

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