Dopamine News and Research

Latest Dopamine News and Research

SynAgile announces positive results from Phase 2a trial of continuous intraoral LD/CD therapy

SynAgile Corporation, a privately held pharmaceutical company that develops and commercializes drug delivery systems using its proprietary OraFuse intraoral technology platform, today announced positive results from a proof-of-concept, Phase 2a, open-label clinical trial of continuous intraoral administration of levodopa-carbidopa (LD/CD).

8 Oct 2015

Neurocrine Biosciences announces positive data from NBI-98854 Phase III trial in tardive dyskinesia

Neurocrine Biosciences, Inc. announced today that NBI-98854, a highly selective small molecule VMAT2 inhibitor, showed a statistically significant reduction in tardive dyskinesia during the six weeks of placebo-controlled treatment in the Kinect 3 clinical trial. This Phase III trial included moderate to severe tardive dyskinesia patients with underlying schizophrenia, schizoaffective disorder, bipolar or major depressive disorder.

8 Oct 2015

Controlling TH-containing neurons can manipulate maternal behavior of females and aggression of males

Most female mammals give birth and care for their offspring, while the males often breed with multiple partners and play little role in parenting once the mating is over. Yet researchers have had a hard time pinpointing where, exactly, in the brain these differences between the sexes are located and how they translate into behavior. The extent of "hardwired parental behavior" is hotly disputed.

8 Oct 2015

Dopamine transmission mediated by D1 receptors essential for controlling movements in Parkinson's disease

Dopamine deficiency in the basal ganglia (a set of subcortical structures) causes severe motor dysfunctions, such as slowness of movements (bradykinesia), as observed in Parkinson's disease. Dopamine binds D1 and D2 receptors that are expressed in the nerve cells of the striatum (a structure of the basal ganglia), and exerts different effects on the nerve cells. However, how dopamine controls through these receptors the information flow in the basal ganglia and voluntary movements is still not clear.

6 Oct 2015

New flame retardant created to replace commercial additives that are often toxic

Inspired by a naturally occurring material found in marine mussels, researchers at The University of Texas at Austin have created a new flame retardant to replace commercial additives that are often toxic and can accumulate over time in the environment and living animals, including humans.

6 Oct 2015

Type-2 diabetes medication can affect the brain's reward system, reduce intake of food

Many studies have focused on how much we eat when we are hungry, but sometimes we eat just to feel better. A new dissertation at Sahlgrenska Academy shows that medication used for type-2 diabetes wich mimics the gut-brain hormone glucagon-like peptide-1, can affect the brain's reward system and reduce the intake of food.

29 Sep 2015

Study: Increased acetylation of histones promotes fear extinction in mice

The targeted modulation of gene activity and cellular signaling pathways could provide a new approach to the treatment of fear and anxiety states according to the recent findings of a project sponsored by the Austrian Science Fund FWF.

29 Sep 2015

Medication used for diabetes could be a valuable tool for treating alcohol dependence

A new study on mice and rats at Sahlgrenska Academy shows that a medication used for diabetes and obesity also could be a valuable tool for the treatment of alcohol dependence.

25 Sep 2015

Neuroscientists reveal the brain malady responsible for tinnitus, chronic pain

Neuroscientists at Georgetown University Medical Center and Germany's Technische Universität München say they've uncovered the brain malady responsible for tinnitus and for chronic pain — the uncomfortable, sometimes agonizing sensations that persist long after an initial injury.

24 Sep 2015

Innovative detector could expand use of polarized light for drug screening, surveillance

Invention of the first integrated circularly polarized light detector on a silicon chip opens the door for development of small, portable sensors that could expand the use of polarized light for drug screening, surveillance, optical communications and quantum computing, among other potential applications.

23 Sep 2015

Disrupting specific signaling pathway in the brain can cause overeating of high fat foods

Defective signaling in the brain can cause overeating of high fat foods in mice, leading to obesity, according to one of the first research articles published in the new open access journal Heliyon.

22 Sep 2015

Olfactory function may inform Parkinson’s prognosis

Olfactory function is preserved in about a quarter of patients with Parkinson’s disease, and may be predictive of disease course, say researchers.

18 Sep 2015

Three studies point to mGluR2 as new molecular target for addiction treatment

The latest issue of Biological Psychiatry presents the results of three studies implicating metabotropic glutamate receptor 2 (mGluR2) as a new molecular target for the treatment of addiction.

15 Sep 2015

UNC scientists create smarter immune cells to treat Parkinson's disease

As a potential treatment for Parkinson's disease, scientists at the University of North Carolina at Chapel Hill have created smarter immune cells that produce and deliver a healing protein to the brain while also teaching neurons to begin making the protein for themselves.

14 Sep 2015

Study reveals why long-term use of L-DOPA leads to dyskinesia

Researchers have discovered why long-term use of L-DOPA (levodopa), the most effective treatment for Parkinson's disease, commonly leads to a movement problem called dyskinesia, a side effect that can be as debilitating as Parkinson's disease itself.

11 Sep 2015

Study shows external brain stimulation temporarily improves motor symptoms in Parkinson's patients

People with Parkinson's disease (PD) tend to slow down and decrease the intensity of their movements even though many retain the ability to move more quickly and forcefully.

10 Sep 2015

Studies suggests that insular cortex may hold key to treating addiction

A pair of studies suggests that a region of the brain - called the insular cortex - may hold the key to treating addiction. Scientists have come to this conclusion after finding that smokers who suffered a stroke in the insular cortex were far more likely to quit smoking and experience fewer and less severe withdrawal symptoms than those with strokes in other parts of the brain.

8 Sep 2015

Dopamine News and Research

Latest Dopamine News and Research

SynAgile announces positive results from Phase 2a trial of continuous intraoral LD/CD therapy

Neurocrine Biosciences announces positive data from NBI-98854 Phase III trial in tardive dyskinesia

Controlling TH-containing neurons can manipulate maternal behavior of females and aggression of males

Dopamine transmission mediated by D1 receptors essential for controlling movements in Parkinson's disease

New flame retardant created to replace commercial additives that are often toxic

Type-2 diabetes medication can affect the brain's reward system, reduce intake of food

Study: Increased acetylation of histones promotes fear extinction in mice

Medication used for diabetes could be a valuable tool for treating alcohol dependence

Neuroscientists reveal the brain malady responsible for tinnitus, chronic pain

Innovative detector could expand use of polarized light for drug screening, surveillance

Disrupting specific signaling pathway in the brain can cause overeating of high fat foods

Olfactory function may inform Parkinson’s prognosis

Three studies point to mGluR2 as new molecular target for addiction treatment

UNC scientists create smarter immune cells to treat Parkinson's disease

Study reveals why long-term use of L-DOPA leads to dyskinesia

Study shows external brain stimulation temporarily improves motor symptoms in Parkinson's patients

Studies suggests that insular cortex may hold key to treating addiction

Sadness impairs basic visual processes involved in color perception, shows study

Cognitive impairment may be part of prodromal PD

Scientists pinpoint neurons responsible for alcohol consumption

Quality, Patient Safety and Innovation Manager at Elsevier

How Bruker worked with the University of Manchester on mapping the dynamics of complex protein

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Dopamine News and Research

Latest Dopamine News and Research

Quality, Patient Safety and Innovation Manager at Elsevier

How Bruker worked with the University of Manchester on mapping the dynamics of complex protein

Real-time Raman monitoring for pharmaceutical hot melt extrusion

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