Down Syndrome

Down syndrome is a chromosomal abnormality characterized by the presence of an extra copy of genetic material on the 21st chromosome, either in whole (Trisomy 21) or in part (such as due to translocations). The effects of the extra copy vary greatly among people, depending on the extent of the extra copy, genetic history and pure chance. In 2007, the American College of Obstetricians and Gynecologists (ACOG) endorsed guidelines that offer risk assessment to all pregnancies for fetal chromosomal abnormalities, including Down syndrome. It is estimated that approximately 70%, or 2.8 million, women undergo Down syndrome screening in the United States each year.
What is Down Syndrome?

Down syndrome or Down's syndrome, is a congenital condition that usually causes some degree of learning disability and is typically characterized by certain physical features.

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Latest Down Syndrome News and Research

Historic DNA analysis identifies Down and Edwards syndromes in ancient humans

Historic DNA analysis identifies Down and Edwards syndromes in ancient humans

Speech Accessibility Project starts recruitment of U.S. and Puerto Rican stroke survivors

Speech Accessibility Project starts recruitment of U.S. and Puerto Rican stroke survivors

Researchers uncover a gene that causes heart defects in Down syndrome

Researchers uncover a gene that causes heart defects in Down syndrome

Study finds reduction in mortality rate among children born with Down syndrome and heart defect

Study finds reduction in mortality rate among children born with Down syndrome and heart defect

Ancient DNA reveals first prehistoric cases of Turner and Jacob's syndromes

Ancient DNA reveals first prehistoric cases of Turner and Jacob's syndromes

Paternal sperm microRNAs also play a role in offspring health

Paternal sperm microRNAs also play a role in offspring health

Speech Accessibility Project expands to include ALS patients in U.S. and Puerto Rico

Speech Accessibility Project expands to include ALS patients in U.S. and Puerto Rico

Enlarged perivascular spaces in infancy associated with sleep problems and autism risk

Enlarged perivascular spaces in infancy associated with sleep problems and autism risk

Gamma stimulation may improve memory and cognition in people with Alzheimer's disease

Gamma stimulation may improve memory and cognition in people with Alzheimer's disease

Study finds people with cognitive disabilities are less satisfied with health care

Study finds people with cognitive disabilities are less satisfied with health care

Regular exercise can improve cognitive and physical, health of adults with Down syndrome

Regular exercise can improve cognitive and physical, health of adults with Down syndrome

RNA-based therapy shows promise for treating leukemia in animal models

RNA-based therapy shows promise for treating leukemia in animal models

Non-invasive genetic test for fetal DNA sequencing developed

Non-invasive genetic test for fetal DNA sequencing developed

Genetic vulnerability of leukemia cells uncovered

Genetic vulnerability of leukemia cells uncovered

States reconsider religious exemptions for vaccinations in child care

States reconsider religious exemptions for vaccinations in child care

Texas A&M researchers win NIH grant to study metabolism in people with Down syndrome

Texas A&M researchers win NIH grant to study metabolism in people with Down syndrome

Medicaid plays critical role in the health and well-being of adults with Down syndrome

Medicaid plays critical role in the health and well-being of adults with Down syndrome

Speech Accessibility Project needs more participants with Parkinson's

Speech Accessibility Project needs more participants with Parkinson's

$11 million NIH grant focuses on cognitive function in Down syndrome-associated Alzheimer’s

$11 million NIH grant focuses on cognitive function in Down syndrome-associated Alzheimer’s

Study reveals two key mechanisms underlying high risks from lung infections in Down syndrome

Study reveals two key mechanisms underlying high risks from lung infections in Down syndrome