Epigenetics News and Research

Latest Epigenetics News and Research

Age when a woman's periods start may affect her children's growth rate

Researchers from the Medical Research Council and University of Cambridge, led by Dr Ken Ong, studied the association between mother's age at first menstruation, mother's adult body size and obesity risk, and children's growth and obesity risk in 6,009 children from the UK Avon Longitudinal Study of Parents and Children (ALSPAC) in Bristol.

25 Apr 2007

M. D. Anderson wins $8.3-million to research environmental causes of major diseases

An $8.3-million federal grant to The University of Texas M. D. Anderson Cancer Center Science Park - Research Division addresses the complex interplay between such varied factors as genetics, diet, and environmental exposure to toxins that cause cancer, asthma, diabetes, cardiovascular and other diseases.

21 Apr 2007

More effective therapies for individual cancers - personalized medicine

Genetic and epigenetic variations ensure that no two people are exactly alike, and the same holds true for any two cancers.

18 Apr 2007

Epigenetic factors that increase breast cancer risk

Women can encounter environmental factors that increase their risk of breast cancer at various periods of their physical development, beginning before birth and extending until menopause.

16 Apr 2007

Environmental contamination could affect the evolution of wildlife through changes in mating behavior

Female rats avoid males whose great-grandfathers were exposed to a common fruit crop fungicide, preferring instead males whose ancestors were uncontaminated, researchers from The University of Texas at Austin have discovered.

2 Apr 2007

Cancer is a stem cell issue

There is an urgent reason to study stem cells: stem cells are at the heart of some, if not all, cancers. Mounting evidence implicates a clutch of rogue stem cells brandishing 'epigenetic' marks as the main culprits in cancer. Wiping out tumours for good, some biologists believe, depends on uprooting these wayward stem cells.

19 Feb 2007

Epigenetics to shape stem cell future

Everyone hopes that one day stem cell-based regenerative medicine will help repair diseased tissue. Before then, it may be necessary to decipher the epigenetic signals that give stem cells their unique ability to self-renew and transform them into different cell types.

19 Feb 2007

Scientists discover enzym that activates epigenetically silenced genes

For several years now, cancer researchers have been studying a mechanism that contributes to the development of malignant tumors: The cell attaches small molecules containing a carbon atom, called methyl groups, to specific building blocks of DNA, thereby individually switching off the genes thus labeled.

11 Feb 2007

New embryonic cell discovery

Cambridge scientists have discovered the stage at which some of the cells of a fertilised mammalian egg are fated to develop into stem cells and why this occurs.

10 Jan 2007

Leukemia gene changes genetic packaging

A signaling system involved in many forms of leukemia and lymphoma is more powerful than scientists have thought, exerting control over our genes by affecting whole swaths of chromosomes in global fashion.

6 Aug 2006

Aggressive melanoma cells secrete Nodal - protein critical to embryo formation

A Northwestern University research group has discovered that aggressive melanoma cells secrete Nodal, a protein that is critical to proper embryo formation.

6 Aug 2006

DNA of human embryonic stem cells is chemically modified in a characteristic, predictable pattern

Embryonic stem cells are derived from embryos that are undergoing a period of intense cellular activity, including the chemical addition of methyl groups to specific DNA sequences in a process known as DNA methylation.

6 Aug 2006

Men transmit multiple sclerosis to their children 2.2 times more often than women

This study involved an investigation of 444 children of an MS-affected father or mother from 3,598 individuals in 206 families to compare the transmission of MS between affected men and women.

25 Jul 2006

Altered activity in receptor pair points to further complexity in schizophrenia pathology

Researchers at the University of Pennsylvania School of Medicine, in collaboration with scientists at the City University of New York, have identified a striking dysregulation in neuronal receptor activity in the postmortem brain tissue from patients with schizophrenia.

18 Jun 2006

Exposure to environmental estrogens during development of the prostate gland in the male fetus may lead to later prostate cancer risk

A study in the June 1 issue of Cancer Research presents the first evidence that exposure to low doses of environmental estrogens during development of the prostate gland in the male fetus may result in a predisposition to prostate cancer later in life.

1 Jun 2006

Dietary folate intake may decrease risk of bladder cancer

Genetic alterations, epigenetic events and environmental exposures all contribute to the development of bladder cancer.

10 May 2006

Gene silencing protein discovered

A team of researchers, including biologists at Washington University in St. Louis, has discovered the key role one protein plays in a major turn-off -in this case, the turning off of thousands of nearly identical genes in a hybrid plant.

8 May 2006

Discovery brings embryonic stem cell medicine a step closer

A team of scientists announced a critical step on the path of realizing the promise of embryonic stem (ES) cells for medicine. The researchers have discovered unique molecular imprints coupled to DNA in mouse ES cells that help explain the cells' rare ability to form almost any body cell type. These imprints, or "signatures," appear near the master genes that control embryonic development and probably coordinate their activity in the early stages of cell differentiation. Not only do these findings help to unlock the basis for ES cells' seemingly unlimited potential, they also suggest ways to understand why ordinary cells are so limited in their abilities to repair or replace damaged cells.

26 Apr 2006

Studies indicate stem cells are flexible enough to become any cell in the body

Two studies in the April 21, 2006 Cell report new details of the "genetic program" that affords embryonic stem cells the flexibility to give rise to any cell type in the body. Both groups identified mechanisms by which the embryonic stem cells of mice or humans keep from going down any one particular developmental path--that of muscle or nervous tissue, for example--while remaining "poised for activation."

26 Apr 2006