Epigenetics

Epigenetics is the study of chemical reactions that influence gene expression, through activation or deactivation of genes at specific times and locations.

How Diet Influences Gene Expression Through Epigenetic Mechanisms

This article explains how diet creates sustained epigenetic changes that affect long-term health, disease risk, aging, and future environmental responses.

Nutritional Epigenetics: How Food Shapes Genes Before Birth

Age-Related Changes in Immune Function: Immunosenescence and Immune Modulation

Effects of Social and Economic Deprivation on Cancer Mortality

What is Nutritional Genomics (Nutrigenomics)?

Understanding Synthetic Epigenetics

How the Placenta Predicts Lifelong Health and Disease Risk

Understanding the Role of Epigenetics in Cancer

ChIP-Seq Analysis: Histone Modifications

Can Cannabis Use Alter Sperm DNA?

How an Anti-Inflammatory Diet Lowers Chronic Disease Risk

See more featured articles »

ChIP-seq Advantages and Limitations

The 'Omics in Male Fertility Diagnostics

Epigenetic Mechanisms in Type 2 Diabetes

The Exposome Framework: Connecting Pollution, Diet, and Disease Pathways

Systemic Telomere Length and Aging

Cholangiocyte Biology and Its Implications in Cholangiopathies

The Role of Epigenetics in Human Disease

Epigenetics in Drug Discovery: Modulating Gene Expression for Health

Epigenetics for Multiple Sclerosis

Effect of Environmental Toxicants on Developing Neurodegenerative Conditions

What Is Epigenetic Reprogramming—and Could It Reverse Aging?

Nutritional Epigenetics: How Food Shapes Genes Before Birth

High-throughput single-cell DNA methylation profiling

What is Single-Molecule Real-Time (SMRT) Sequencing?

Ovarian Aging Explained: Biological Age, Fertility, and Epigenetic Markers

Latest Epigenetics News and Research

GADD45B promotes apoptosis in intestinal injury through DNA demethylation

Intestinal ischemia/reperfusion (I/R) injury is a common pathophysiological phenomenon that is widely present in various primary intestinal diseases and systemic critical illnesses, potentially leading to multiple organ dysfunction and failure, with high morbidity and mortality.

5 May 2026

Estrogen loss after menopause impacts heart health through gene regulation

Virginia Tech scientists at the Fralin Biomedical Research Institute say the increased risk of cardiovascular disease after menopause may stem not only from declining hormone levels, but also from how those changes influence gene activity.

27 Apr 2026

Study identifies epigenetic patterns affecting insulin and glucagon production in type 2 diabetes

Researchers at Lund University in Sweden have carried out the most detailed mapping to date of the epigenome in the cells that regulate the body's blood sugar levels.

24 Apr 2026

Early childhood interventions may safeguard brain health after maternal stress

Researchers from the City University of New York (CUNY) Graduate Center and Queens College suggest that building strong adaptive skills in early childhood may serve as a buffer against the detrimental effects of prenatal stress on a child's developing brain.

24 Apr 2026

APC-deficient cancer cells rely on single enzyme for survival

A newly published study reports that APC-deficient cancer cells may depend on a single metabolic enzyme for survival, revealing a potential strategy for selectively targeting tumours associated with one of the most common mutations in colorectal cancer.

20 Apr 2026

Scientists discover a biological "memory" of breastfeeding in child blood samples

Babies who are exclusively breastfed for at least three months carry markers in their blood that differ from babies who are not breastfed.

16 Apr 2026

Mitochondrial activity keeps dendritic cells ready to fight disease

Researchers at the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) show that active mitochondria maintain dendritic cells, the immune system's sentinels, in a "ready-to-respond" state, linking cellular metabolism to gene regulation and T-cell activation.

15 Apr 2026

Targeting super-enhancer mechanisms offers new strategies for cancer therapy

Super-enhancers (SEs) are large clusters of transcriptional regulatory elements that drive oncogene expression, maintain malignancy, and create "transcriptional addiction" in cancer.

13 Apr 2026

Pseudogene lncRNAs regulate cancer stem cell behavior and signaling

Cancer stem cells (CSCs), a critical subpopulation within tumors, drive cancer initiation, progression, metastasis, relapse, and resistance to therapy due to their innate capacity for self-renewal and differentiation.

11 Apr 2026

Non-clinical safety assessment crucial for CRISPR-based gene therapies

The rapid evolution of CRISPR/Cas genome editing has redefined the possibilities of cellular and gene therapy, enabling precise correction, disruption, and regulation of disease-associated genes.

10 Apr 2026

Intense light therapy reduces hypoxia-induced heart damage in mice

Right ventricular (RV) remodeling and dysfunction are serious cardiovascular consequences due to prolonged hypoxic exposure, commonly seen in conditions such as chronic lung disease and high-altitude environments.

10 Apr 2026

Early epigenetic changes shape infant gut microbiome development

The gut microbiome and epigenetics-molecular switches that turn genes on or off-are intertwined, and both contribute to neurodevelopment, finds a study publishing April 10 in the Cell Press journal Cell Press Blue.

10 Apr 2026

Study explains why current BET inhibitors fail in cancer treatment

For over a decade, a class of drugs called BET inhibitors has been tested in cancer trials with high expectations.

9 Apr 2026

Treating heart failure patients with i.v. furosemide and HSS reduces inflammatory, remodeling markers

A new research paper was published in Volume 18 of Aging-US on March 26, 2026, titled "Effects of intravenous furosemide plus small-volume hypertonic saline solutions on inflammatory, remodeling markers and epigenetics signatures of patients with congestive acute decompensated heart failure (ADHF)."

7 Apr 2026

Lactate modification fuels drug resistance and immune escape in cancer

Published in Current Molecular Pharmacology, a comprehensive review led by Yong Xu and colleagues from Shanghai Pulmonary Hospital explores the emerging role of lactylation, a post-translational modification driven by lactate, in lung cancer progression and drug resistance.

7 Apr 2026

New strategy exploits specific genetic vulnerability in colorectal cancer patients

Researchers have identified a novel therapeutic approach for colorectal cancer by exploiting a specific genetic vulnerability found in a majority of patients.

6 Apr 2026

How gut microbes may shape heart attack damage and recovery

This review argues that gut microbes and the metabolites they produce, especially SCFAs and TMAO, may shape how the heart responds to myocardial infarction through epigenetic pathways such as DNA methylation, histone modification, and non-coding RNAs. It also outlines potential intervention routes, including diet, probiotics, postbiotics, and metabolite-targeted therapies, while noting that much of the evidence remains translational and not yet clinically definitive.

6 Apr 2026

Metformin mimics exercise-related metabolic effects in prostate cancer patients

A new study has found that metformin, a widely prescribed diabetes drug, may mimic one of exercise's core biological effects in men with prostate cancer, raising levels of a molecule tied to energy balance and weight control even when patients are inactive.

6 Apr 2026

How vitamin D in the first 1,000 days may shape lifelong health

This narrative review argues that vitamin D is clearly important for skeletal health during the first 1,000 days of life and may also shape immune, metabolic, and selected neurodevelopmental pathways during early development. However, the authors stress that human evidence for most non-skeletal outcomes remains heterogeneous, with benefits appearing most consistent in populations with baseline deficiency.

31 Mar 2026

Alcohol impacts gene expression differently across brain regions

Erica Periandri and Gabor Egervari, from Washington University in St. Louis, led a study to explore how alcohol exposure in male mice influences gene expression and mechanisms that regulate gene function-or epigenetics.

30 Mar 2026