Immunology News and Research

Latest Immunology News and Research

Phase 1 clinical studies reveal safety, tolerability of therapeutic vaccine in celiac disease patients

ImmusanT, Inc., a clinical-stage company developing Nexvax2, a therapeutic vaccine intended to protect against the effects of gluten exposure while maintaining a gluten-free diet in HLA-DQ2.5+ patients with celiac disease, today announced the publication of positive data from two Phase 1 clinical trials of Nexvax2 in celiac disease.

12 May 2017

Scientists discover free C3d protein that mitigates tumor-induced immunosuppression

In the body, anti-cancer immunity is immobilized by stealth cancer forces. But a natural de-immobilizer has been identified - and it has a vendetta.

12 May 2017

Scientists reveal how immune cells activate to kill parasitic worms

An international team of researchers including Zissis C. Chroneos, associate professor of pediatrics, and microbiology and immunology at Penn State College of Medicine, reveals how immune cells called macrophages activate to kill parasitic worms.

11 May 2017

New study reveals 80% of stethoscopes are contaminated with infectious bacteria

There are now two reasons for patients to flinch at the touch of a stethoscope: because it's cold, of course; and because it's covered with germs.

11 May 2017

CUMC researchers create new organoids that mimic features of full-sized lung

New lung "organoids"-tiny 3-D structures that mimic features of a full-sized lung- have been created from human pluripotent stem cells by researchers at Columbia University Medical Center. The team used the organoids to generate models of human lung diseases in a lab dish, which could be used to advance our understanding of a variety of respiratory diseases.

11 May 2017

Early-onset pancreatitis in children linked to family history and genetic mutations

A study published today in The Journal of Pediatrics suggests that early-onset pancreatitis in children is strongly associated with certain genetic mutations and family history of pancreatitis.

10 May 2017

New findings pinpoint key feature of rare childhood disease that could help fast-track diagnosis

Australian scientists have shown, for the first time, that a family of untethered proteins builds up in the cells of children with a rare and serious genetic condition, known as mevalonate kinase deficiency (MKD).

10 May 2017

Researchers uncover structure of embryo-protecting protein

Revelations about a protein expressed in fetal cells could provide novel insights into its function and future immunosuppressive therapies.

10 May 2017

New trial aims to prolong remission for pediatric leukemia patients treated with T-cell immunotherapy

After phase 1 results of Seattle Children's Pediatric Leukemia Adoptive Therapy trial have shown T-cell immunotherapy to be effective in getting 93 percent of patients with relapsed or refractory acute lymphoblastic leukemia into complete initial remission, researchers have now opened a first-in-human clinical trial aimed at reducing the rate of relapse after the therapy, which is about 50 percent.

9 May 2017

Researchers discover that microRNA can prevent excessive intestinal inflammation

An international team of researchers has discovered that a microRNA produced by certain white blood cells can prevent excessive inflammation in the intestine.

9 May 2017

Metabolite 'signatures' can accurately distinguish typhoid from other fever-inducing diseases

Researchers have identified a metabolite 'signature' that can accurately distinguish typhoid from other fever-inducing tropical diseases using patient blood samples.

9 May 2017

Dendritic cells develop from specialized progenitors, research shows

Dendritic cells are gatekeepers of Immunity and are crucial for the detection and initiation of Immunity against pathogens and foreign substances. Up to now dendritic cell subtypes were thought to develop from one common progenitor.

5 May 2017

New research identifies immunotherapy targets to offer hope for early-stage lung cancer patients

Immunotherapy, which has achieved remarkable results in late-stage lung cancer patients, can also hold great hope for newly diagnosed patients, cutting the deadly disease off before it has the chance to take hold and offering a potential cure, according to a new Mount Sinai study published today in Cell.

4 May 2017

Scientists identify how key skin barrier protein drives development of eczema

Scientists have uncovered evidence that a deficiency in the skin's barrier is key to triggering eczema. The team at Newcastle University, in collaboration with scientists at Stiefel, a GSK company, have identified how a key skin barrier protein called filaggrin impacts on other proteins and pathways in the skin, which in turn drive the development of eczema.

4 May 2017

Phthalate exposure linked to increased risk of allergies among children

Phthalates, which are used as plasticizers in plastics, can considerably increase the risk of allergies among children.

3 May 2017

Shire and Parion Sciences to collaborate on P-321 for ophthalmic indications

Shire plc and Parion Sciences, Inc. have announced they have entered into an agreement granting Shire exclusive worldwide rights to develop and commercialize P-321. Shire will lead development of P-321, an investigational epithelial sodium channel (ENaC) inhibitor for the potential treatment of dry eye disease in adults, with the opportunity for Parion to co-fund.

3 May 2017

New study shows that gene editing technology can shut down HIV-1 replication in animals

A permanent cure for HIV infection remains elusive due to the virus's ability to hide away in latent reservoirs. But now, in new research published in print May 3 in the journal Molecular Therapy, scientists at the Lewis Katz School of Medicine at Temple University and the University of Pittsburgh show that they can excise HIV DNA from the genomes of living animals to eliminate further infection.

2 May 2017

Different doses of resistance exercises could aid recovery from infection, injury

Having your healthcare professional prescribe you a dose of bench presses to ward off an infection or help heal an injury may sound like shonky healthcare but could actually be the advice of the near future, according to Griffith University scientists.

29 Apr 2017

Penn State establishes new $2.4-million Biomedical Big Data to Knowledge Training Program

A new $2.4-million program for graduate students seeking to contribute to breakthrough discoveries in medicine and biology has been established at Penn State University with nearly $1.4 million in funding from the National Library of Medicine of the U.S. National Institutes of Health and more than $1 million from Penn State.

28 Apr 2017

Researchers show resident T cells in the skin depend on CD103 molecule for their anti-tumor function

The molecule CD103 is key to the long-term residence of T cells in the skin and to their anti-tumor function, report a team of researchers at the Medical University of South Carolina and the Dartmouth-Hitchcock Norris Cotton Cancer Center In the April 14, 2017, Science Immunology.

28 Apr 2017

Immunology News and Research

Latest Immunology News and Research

Phase 1 clinical studies reveal safety, tolerability of therapeutic vaccine in celiac disease patients

Scientists discover free C3d protein that mitigates tumor-induced immunosuppression

Scientists reveal how immune cells activate to kill parasitic worms

New study reveals 80% of stethoscopes are contaminated with infectious bacteria

CUMC researchers create new organoids that mimic features of full-sized lung

Early-onset pancreatitis in children linked to family history and genetic mutations

New findings pinpoint key feature of rare childhood disease that could help fast-track diagnosis

Researchers uncover structure of embryo-protecting protein

New trial aims to prolong remission for pediatric leukemia patients treated with T-cell immunotherapy

Researchers discover that microRNA can prevent excessive intestinal inflammation

Metabolite 'signatures' can accurately distinguish typhoid from other fever-inducing diseases

Dendritic cells develop from specialized progenitors, research shows

New research identifies immunotherapy targets to offer hope for early-stage lung cancer patients

Scientists identify how key skin barrier protein drives development of eczema

Phthalate exposure linked to increased risk of allergies among children

Shire and Parion Sciences to collaborate on P-321 for ophthalmic indications

New study shows that gene editing technology can shut down HIV-1 replication in animals

Different doses of resistance exercises could aid recovery from infection, injury

Penn State establishes new $2.4-million Biomedical Big Data to Knowledge Training Program

Researchers show resident T cells in the skin depend on CD103 molecule for their anti-tumor function

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