Metabolism News and Research

Latest Metabolism News and Research

Alzheimer’s disease risk genes disturb the brain protective mechanism

The brain has a natural protective mechanism against Alzheimer's disease, and researchers at Baylor College of Medicine, Texas Children's Hospital and collaborating institutions have discovered that gene variants associated with risk of developing the disease disturb the protective mechanism in ways that can lead to neurodegeneration.

3 Jan 2022

Study uses metabolomics to discriminate drug-induced liver injury phenotypes

Drug-induced liver injury (DILI) is an adverse reaction to ingesting a drug, which can appear both in developmental stages, in their clinical use and even after being approved as a drug.

30 Dec 2021

Exploring the importance of selenium in COVID-19 patients

In a new study, researchers reviewed research on the role that selenium could play in protecting individuals against coronavirus disease 2019.

29 Dec 2021

Significant gaps found in nutrition-related care for patients with kidney disease

Dietary and nutritional changes are needed when patients develop kidney disease; however, new research published in CJASN reveals that in many countries, there are significant gaps in care related to the importance of nutrition for maintaining kidney health.

29 Dec 2021

New techniques enable visualization of DNA repair machinery in detail

Each one of the trillions of cells that make up the human body suffers more than 10,000 DNA lesions every day. These injuries would be catastrophic if cells were unable to repair them, but a very delicate machinery that detects and repair genetic damage is at work to prevent DNA mutations and diseases such as cancer.

29 Dec 2021

Introducing deuterium makes drugs to have a longer effect

Hydrogen (abbreviated "H") is the lightest of all elements. It usually consists only of a positively charged proton and a negatively charged electron and is also called protium in this form. But there are also two heavier hydrogen isotopes, deuterium and tritium.

24 Dec 2021

Flexibility may maximize the potency of peptides used to treat Type 2 diabetes

A little wiggle room might be just what the doctor ordered. New research suggests that the peptides - short chunks of protein - used to treat Type 2 diabetes may be more effective if they're able to flexibly move back and forth between different shapes.

23 Dec 2021

Eating sugar is healthy for some Greenlanders with a genetic variation

A genetic variation among some Greenlanders makes sugar healthy – significantly more than for most people.

22 Dec 2021

Researchers receive NIH grants to develop new treatments for neglected tropical diseases

Researchers at Washington University School of Medicine in St. Louis have received two grants from the National Institutes of Health totaling more than $5.5 million to develop new treatments for two types of devastating parasitic infections common in sub-Saharan Africa and Central and South America: river blindness and intestinal worm infections.

22 Dec 2021

Study points toward an alternative drug strategy to stall Alzheimer’s neurodegeneration

Boosting levels of the neurotransmitter norepinephrine with atomoxetine, a repurposed ADHD medication, may be able to stall neurodegeneration in people with early signs of Alzheimer's disease, a study conducted at Emory Brain Health Center suggests.

22 Dec 2021

Newly discovered species of Enterococcus bacteria named after the John Innes Centre

A newly discovered species of antibiotic-resistant bacteria has been named after the academic institute where it was identified – the John Innes Centre.

22 Dec 2021

Amino acid valine plays a key role in the growth of T cell acute lymphoblastic leukemia

A molecular building block of many animal proteins, the amino acid valine, plays a key role in cancerous growth seen in T cell acute lymphoblastic leukemia, a new study shows.

22 Dec 2021

High-altitude activities may increase the risk of hypoglycemia in people with diabetes

People with diabetes may need to monitor their blood sugar more closely when doing high-altitude activities such as hiking or skiing, according to a small study published in the Society's Journal of Clinical Endocrinology & Metabolism.

22 Dec 2021

Promising new drug target for TB identified

Mycobacterium tuberculosis (Mtb), the hardy bacterial species that causes tuberculosis (TB), has an unexpected vulnerability that future drugs may be able to exploit, according to a study from researchers at Weill Cornell Medicine.

21 Dec 2021

SGLT2 inhibitor empagliflozin can be used to treat insulin resistance in the brain, finds study

Overweight or obesity, an unfavorable distribution of fat in the body and the development of type 2 diabetes are often associated with a reduced effect of the hormone insulin in many organs, including the brain (insulin resistance).

21 Dec 2021

Researchers use machine learning to shed light on genetic mutations linked with spina bifida

Weill Cornell Medicine researchers are using machine learning, a form of artificial intelligence, to shed light on genetic mutations associated with spina bifida.

20 Dec 2021

New study shows how regular exercise protects against fatty liver disease

Exercise not only trains the muscles but can also prevent the development of fatty liver. A new study by the German Center for Diabetes Research, Helmholtz Munich and Tübingen University Hospital shows which molecular adaptations, in particular of the liver mitochondria, can be observed in this process.

20 Dec 2021

UBR7 protein acts as a histone chaperone during DNA replication, study finds

The protein UBR7 acts as a histone chaperone, regulating histone re-deposition at specific sites during DNA replication, according a recent study published in The EMBO Journal.

20 Dec 2021

Study reveals chromosome-level changes that relate to drug resistance in melanoma

Precision therapies targeting melanoma and other cancers have improved patient survival, but tumors often stop responding to drugs, and recent studies point to changes in DNA – both inside and outside chromosomes – as a driving factor in tumor genesis as well as in treatment resistance.

20 Dec 2021

Impact of acute kidney injury associated gene expression in human kidney cells

A new study attempts to perform a comparative single-cell census of human kidneys employing samples from individuals suffering from acute kidney injury and controls without the condition.

20 Dec 2021

Metabolism News and Research

Latest Metabolism News and Research

Alzheimer’s disease risk genes disturb the brain protective mechanism

Study uses metabolomics to discriminate drug-induced liver injury phenotypes

Exploring the importance of selenium in COVID-19 patients

Significant gaps found in nutrition-related care for patients with kidney disease

New techniques enable visualization of DNA repair machinery in detail

Introducing deuterium makes drugs to have a longer effect

Flexibility may maximize the potency of peptides used to treat Type 2 diabetes

Eating sugar is healthy for some Greenlanders with a genetic variation

Researchers receive NIH grants to develop new treatments for neglected tropical diseases

Study points toward an alternative drug strategy to stall Alzheimer’s neurodegeneration

Newly discovered species of Enterococcus bacteria named after the John Innes Centre

Amino acid valine plays a key role in the growth of T cell acute lymphoblastic leukemia

High-altitude activities may increase the risk of hypoglycemia in people with diabetes

Promising new drug target for TB identified

SGLT2 inhibitor empagliflozin can be used to treat insulin resistance in the brain, finds study

Researchers use machine learning to shed light on genetic mutations linked with spina bifida

New study shows how regular exercise protects against fatty liver disease

UBR7 protein acts as a histone chaperone during DNA replication, study finds

Study reveals chromosome-level changes that relate to drug resistance in melanoma

Impact of acute kidney injury associated gene expression in human kidney cells

How microRNA is transforming science: From discovery to diagnostics

Advancing benzodiazepine detection

The Surgeon-Scientist Pioneering Regenerative Engineering