Pain News and Research

Latest Pain News and Research

Study shines light on how P2X4 receptor can be inhibited

A study carried out by the University of Bonn and the University Hospital Bonn throws light on how an important receptor can be inhibited.

5 Dec 2025

First new fibromyalgia drug in 15 years, Tonmya (cyclobenzaprine HCl) gains FDA approval and hits pharmacy shelves

In a milestone moment for chronic pain management, Tonix Pharmaceuticals announced on August 15, 2025, that its novel sublingual therapy Tonmya has received approval from the U.S. Food and Drug Administration (FDA) - marking the first new drug for Fibromyalgia in more than 15 years.

From Hanson Wade Group - Non-Opioid Pain Therapeutics Summit 5 Dec 2025

Concussion history accurately predicts long-term health in former NFL players

A UNC-Chapel Hill study conducted by the Matthew Gfellar Center studied more than 1,500 former NFL players found that two of the most commonly used ways to estimate head injury risk, years played and playing position, are not actually linked to poorer long-term physical or mental health.

4 Dec 2025

Dark web users show markedly higher mental health vulnerabilities

The dark web – a hidden corner of the internet accessed through privacy-preserving tools like the Tor browser – operates beyond the reach of traditional search engines and public platforms.

3 Dec 2025

Medical cannabis evidence falls short for most conditions

Medical cannabis lacks adequate scientific backing for most of the conditions it is commonly used to treat, including chronic pain, anxiety and insomnia, according to a comprehensive review led by UCLA Health.

3 Dec 2025

How anger and injustice shape the course of chronic pain

We all know stress can worsen pain, but new research shows that anger and a sense of injustice may be even more powerful triggers. In a study of more than 700 people living with chronic pain, researchers uncovered four distinct "anger profiles" that help explain why some patients hurt more, and longer, than others.

3 Dec 2025

A personalized approach to treating pancreatic cancer

It's not surprising that pancreatic cancer is often referred to as a silent killer. With few early symptoms and an aggressive nature, it has one of the lowest survival rates of all cancers.

3 Dec 2025

Mindfulness can help reduce problematic smartphone use

With more than four billion people around the globe owning a smartphone, researchers are now looking at ways to reduce a growing public health concern-problematic smartphone use.

3 Dec 2025

Daily tracking menstrual cycles show affects on athletes

New research reveals how daily tracking of menstrual and contraceptive symptoms impacts elite athletes' performance and well-being more accurately than surveys.

3 Dec 2025

11 genetic loci that shape impulsive decision-making

Researchers identify distinct genetic loci involved in delay discounting and how these variants are involved in physical and psychiatric health outcomes.

3 Dec 2025

No clear link between paracetamol use in pregnancy and autism or ADHD

Maternal paracetamol use during pregnancy shows weak links to autism and ADHD, with family factors playing a more significant role, offering reassurance.

3 Dec 2025

Automated EHR system triages cancer symptoms, improves care team efficiency

For many people living with cancer, symptoms such as pain, anxiety or insomnia can quickly spiral into an emergency room visit. Such visits can be financially costly and take an emotional toll on patients and their caregivers.

3 Dec 2025

Common nerve pain drugs may set off prescribing cascades in older patients

Clinicians may fail to recognize common side effects of drugs like gabapentin - which are frequently prescribed for nerve pain - leading them to prescribe unnecessary medications that cause yet more side effects.

2 Dec 2025

Study provides new hope for future treatment of intestinal condition IBS

Researchers at örebro University in Sweden have made a significant advance in understanding the intestinal condition IBS.

2 Dec 2025

RFK Jr. wants to delay the hepatitis B vaccine. Here’s what parents need to know.

Working out of a tribal-owned hospital in Anchorage, Alaska, liver specialist Brian McMahon has spent decades treating the long shadow of hepatitis B. Before a vaccine became available in the 1980s, he saw the virus claim young lives in western Alaskan communities with stunning speed.

2 Dec 2025

Generative AI aids discovery of ISM3830's novel scaffold

Casitas B-lineage lymphoma-b (CBLB) is an E3 ubiquitin–protein ligase that functions as an intracellular checkpoint and master negative regulator of T‑cell and natural killer (NK) cell activation, playing a central role in modulating T-cell activation and immune tolerance, and its inhibition enhances T cells and NK cells function, also provides a strategy for the function restoration of exhausted T cells.

1 Dec 2025

Walking speed before hip replacement predicts long-term recovery success

Total hip arthroplasty (hip replacement) is a common treatment for hip osteoarthritis, a degenerative joint disease caused by cartilage in the hip joint wearing down.

1 Dec 2025

Study links endocrine-disrupting chemicals to hidradenitis suppurativa

A Johns Hopkins Medicine study involving a dozen people with the inflammatory skin disease hidradenitis suppurativa (HS), which mostly affects skin folds, is believed to be the first to provide evidence that hormone-disrupting chemicals commonly found in ultra-processed food and single-use water bottles may contribute to the development of or worsen the condition in some people.

1 Dec 2025

Study explores the impact of total knee replacement surgery cancellations across UK hospitals

Thousands of NHS knee replacement operations are cancelled at short notice every year, many for avoidable reasons, according to a new study published today [1 December].

1 Dec 2025

Study finds surprising differences in knee injuries between men and women

One of the largest MRI-based studies comparing knee injuries between men and women reveals surprising differences in injury patterns based on gender and age.

1 Dec 2025