Pain

Using a Pain Diary

A pain diary to record chronic pain patterns and triggers can be useful to improve control of pain management.

Pain in the Lower Right Abdomen: When to be Concerned

Antidepressants in Pain Management

Comparing Nociceptive and Neuropathic Pain

Chronic Pain: The 20 Most Painful Conditions

Latest Pain News and Research

Molecular bumpers and glues rewire GPCR signaling for next-generation medicines

New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and "molecular glues" can rewire G protein-coupled receptor (GPCR) signaling, turning the cell's busiest receptors into precision tools - opening the door to a new generation of safer, smarter medicines.

31 Oct 2025

Novel approaches to understanding EETs and cardiovascular disease

Some products of arachidonic acid have already been well studied: the prostanoids formed by cyclooxygenases are central mediators of inflammation, fever, and pain.

31 Oct 2025

Better treatments buoy multiple-myeloma patients, bound by research cuts and racial disparities

For more than a year, Diane Hunter, now 72, had been experiencing vague symptoms — pain in her spine and hips, nausea, exhaustion, thirst, and frequent urination.

31 Oct 2025

Unusual presentation of vulvar mucinous cyst with multiple bartholin cysts in a reproductive-age woman

A new case report was published in Volume 12 of Oncoscience on October 9, 2025, titled "Vulvar mucinous cyst mimicking common lesions with concurrent multiple bartholin cysts in a reproductive-age woman: A rare case report and review of literature."

30 Oct 2025

Some hormonal contraceptives linked to higher risk of breast cancer

Some common hormonal contraceptives are linked to a slightly higher risk of breast cancer than others.

30 Oct 2025

Scientists uncover why many cancer patients develop chemotherapy-induced neuropathy

Scientists at Wake Forest University School of Medicine, in collaboration with researchers at Weill Cornell Medicine, have made a breakthrough in understanding why many cancer patients develop nerve damage after chemotherapy.

30 Oct 2025

Home exercise alone highly effective for meniscal tear and osteoarthritis pain, says study

People with a meniscal tear and osteoarthritis prescribed home exercises with or without physical therapy reported substantial improvements in knee pain, according to a new study led by Mass General Brigham researchers.

30 Oct 2025

Two analgesic drugs may one day be repurposed as anti-tumor therapies

Peripheral afferent neurons - nerves that send signals from all areas of the body to the central nervous system (brain and spinal cord) - are known to infiltrate and grow within malignant bone tumors called osteosarcomas, often accompanied by severe pain.

29 Oct 2025

Study highlights high prevalence of non-coeliac gluten sensitivity lacking clear markers

Around one in ten people worldwide report gastrointestinal and other symptoms such as fatigue and headache after eating foods containing gluten or wheat despite not having a diagnosis of either coeliac disease or wheat allergy, finds a large systematic review and meta-analysis published online in Gut.

29 Oct 2025

$Reducing femoral fractures in total hip replacement with safer implant designs$

Reducing femoral fractures in total hip replacement with safer implant designs

As populations continue to age, total hip replacement (THR) is becoming an increasingly common surgical procedure.

28 Oct 2025

Study links poor sleep to adverse health outcomes in seniors

Sleep problems affect more than one in five residents in long-term care facilities, with pain, daytime napping and certain medications emerging as key contributors.

28 Oct 2025

Study highlights need to establish clinical practice guidelines for surgical patients receiving MOUDs

In an effort to stem the death toll from opioid overdose, United States public health officials have promoted the prescription and use of medications like buprenorphine that blunt the effects of illicit opioids such as fentanyl.

27 Oct 2025

Adequate support needed to address Canada's rising youth opioid use

Youth opioid use is increasing in Canada, as are related emergency department visits and deaths, yet governments are not providing adequate support to address this public health crisis, argue the authors of a CMAJ.

27 Oct 2025

Research shows a decline in opioid dispensing across Canadian provinces

Efforts to promote safer opioid prescribing in Canada appear to be having an effect, as new research in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.250670 shows a decrease in opioid dispensing between 2018 and 2022.

27 Oct 2025

Excess mortality associated with chronic pain can be avoided through spinal cord stimulation

Treating chronic neuropathic pain with spinal cord stimulation may help prevent excess mortality associated with chronic pain, a new study from the University of Eastern Finland and Kuopio University Hospital shows.

27 Oct 2025

Doctors muffled as Florida moves to end decades of childhood vaccination mandates

Florida plans to end nearly a half-century of required childhood immunizations against diseases that have killed and maimed millions of children. Many critics of the decision, including doctors, are afraid to speak up against it.

27 Oct 2025

New insight into TRPM3 heat sensor reveals how the body detects temperature

The ability to sense heat protects the body from burns and injury. But how the body actually feels temperature has remained an elusive mystery.

24 Oct 2025

Study reveals a troubling surge in severe diverticulitis among Americans younger than 50

A comprehensive analysis of over 5.2 million hospitalizations reveals a troubling surge in severe diverticulitis cases among Americans younger than 50.

24 Oct 2025

Revolutionizing lipid nanoparticle formulations for targeted treatments

Lipid nanoparticles (LNPs) are the delivery vehicles of modern medicine, carrying cancer drugs, gene therapies and vaccines into cells.

24 Oct 2025

Football injuries, not injections, explain why retired players face higher osteoarthritis risk

Retired UK male footballers face a markedly higher risk of foot and ankle osteoarthritis (OA), primarily due to prior injuries sustained during their careers. While corticosteroid injections were linked with OA, this association likely reflects treatment for injury rather than a direct cause.

23 Oct 2025