Pain

Using a Pain Diary

A pain diary to record chronic pain patterns and triggers can be useful to improve control of pain management.

Pain in the Lower Right Abdomen: When to be Concerned

Chronic Pain: The 20 Most Painful Conditions

Comparing Nociceptive and Neuropathic Pain

See more featured articles »

Antidepressants in Pain Management

Latest Pain News and Research

Large US trial supports silver diamine fluoride for severe early childhood caries

A phase 3 randomized trial of 830 young children with severe early childhood caries found that 38% silver diamine fluoride arrested 54.0% of eligible cavitated dentin lesions at six months, compared with 22.5% after placebo. The noninvasive treatment showed clinically meaningful efficacy, but about half of the lesions remained active, supporting close monitoring and additional preventive care.

3 Aug 2026

Digital twin of the gut-brain axis aims to advance neurostimulation therapies

The gut and brain are in constant conversation, exchanging signals that regulate hunger and digestion, as well as the body's response to stress.

3 Aug 2026

New analytical strategies can measure thousands of gut microbial proteins

The trillions of microorganisms living in our intestine influence our health, from digestion and metabolism to immunity.

3 Aug 2026

New discovery advances sustainable production of plant-based medicines

Two plants that cause neurotoxicity and paralysis in the tiniest doses are also known to counter pain, malaria, cancer and pests.

31 Jul 2026

Ketamine boosts neuroplasticity through microglia in female brains

Doctors use ketamine on patients as general anesthesia before surgery. They also prescribe it in low doses for pain management, and more recently, it's been used for treatment-resistant depression where other drugs have failed.

31 Jul 2026

Brain immune cells drive recovery from ketamine anesthesia in females

During ketamine anesthesia, the brain's nerve cells fall silent-as consciousness returns, they begin to reconnect.

31 Jul 2026

Insilico unveils standardized evaluation framework to validate AI-driven drug discovery models

As general-purpose and domain-specific AI models rapidly infiltrate drug discovery, one critical question looms over the pharmaceutical sector: Can these models actually discover drugs, or are they just good at taking tests?

30 Jul 2026

Discovery of calcium channel mechanism offers clues for brain disorder treatments

DGIST (President Kunwoo Lee) announced that a research team led by Professor Byung Chang Suh of the Department of Brain Sciences has, for the first time, uncovered a novel molecular mechanism that regulates the "N-type voltage-gated calcium channel (CaV2.2)," which plays a critical role in neural signal transmission.

29 Jul 2026

FDA grants fast track designation to Insilico's AI-designed mesothelioma drug candidate

Insilico Medicine ("Insilico"; HKEX: 3696), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, today announced that ISM6331, a novel, potential best-in-class pan-TEAD inhibitor driven by Insilico's proprietary AI, has received Fast Track Designation (FTD) from the U.S.

29 Jul 2026

Daily routines reduce pain and depression in older adults

University of Missouri researchers have identified a simple, effective way to improve quality of life. A new study found that maintaining a consistent daily routine can reduce physical pain and ease symptoms of depression, demonstrating how everyday habits can have a meaningful impact on well-being, particularly for older adults with insomnia.

28 Jul 2026

Lifestyle habits may explain difference in endometriosis symptoms

Investigating lifestyle factors, this study highlights their role in quality of life for women with endometriosis, advocating for personalized care strategies.

28 Jul 2026

Landmark study identifies new genetic risk factors linked to fibromyalgia syndrome

In a landmark study published in Nature Medicine, an international team of researchers has identified new genetic risk factors associated with fibromyalgia syndrome.

28 Jul 2026

Dengue virus infects memory B cells to evade immune defenses

Researchers at the University of Vermont Robert Larner, M.D. College of Medicine and Upstate Medical University in Syracuse, NY, have discovered that dengue virus can infect and replicate inside memory B cells, immune cells traditionally understood to help protect the body from infection.

27 Jul 2026

Advancing Drug Safety Assessment With AI, Predictive Modeling, and Human-Relevant Data

James McDonagh discusses how AI and machine learning are transforming drug discovery and safety assessment, enhancing toxicology and decision-making processes.

27 Jul 2026

Novel bioinspired dressing uses body force to heal wounds

A bioinspired material, developed by scientists at Imperial College London, accelerates wound healing and the repair of human skin.

27 Jul 2026

Study discovers new therapeutic targets for severe preeclampsia

Unusual behavior in the cells of mothers and babies with preeclampsia may provide new therapeutic targets for the condition, finds a new UCL-led study.

24 Jul 2026

Two microscopic parasites cause widespread diarrheal illness across America

You've seen the alarming headlines about parasites causing "explosive diarrhea" across the U.S. Two microscopic parasites – cyclospora cayetanensis and cryptosporidium – can both cause prolonged gastrointestinal illness, including watery diarrhea, stomach cramps, and dehydration.

24 Jul 2026

AI platform uncovers promising target for chronic pain treatmen

Despite the widespread availability of analgesics, pain management remains one of the most significant and pervasive challenges in modern medicine, with more than 20% of the global population suffering from chronic pain, especially chronic neuropathic pain characterized by central sensitization.

22 Jul 2026

Exercise may provide limited relief for hip osteoarthritis symptoms

Exercise finds improvements in pain and function may fall short of what patients would notice in daily life, but more studies are needed to make firm conclusions, a new Cochrane review finds.

22 Jul 2026

Experimental neurointerventional technique shows promise for severe back pain

Researchers at the Society of NeuroInterventional Surgery (SNIS) 23rd Annual Meeting presented an experimental neurointerventional technique designed to treat severe back pain, a leading cause of disability and opioid use, by delivering medication directly through the arteries supplying the painful area.

22 Jul 2026