Pain News and Research

Latest Pain News and Research

Gene editing therapy exa-cel improves quality of life in sickle cell disease and beta thalassemia

Treatment with exagamglogene autotemcel (exa-cel) led to robust and sustained improvements in quality of life for patients with severe sickle cell disease (SCD) or transfusion-dependent beta thalassemia, according to two studies published in Blood Advances.

27 Aug 2025

Transcutaneous vagal nerve stimulation shows promise for gastrointestinal disorders

Imbalanced autonomic function, characterized by reduced vagal activity and sympathetic dominance, is increasingly recognized in various gastrointestinal (GI) disorders.

27 Aug 2025

Parents of premature babies have poorer sleep quality, study shows

Long sleepless nights and little rest are for many the beginning of parenthood. But how big is the problem really, and how does it affect our health? Gunhild Nordbø Marthinsen has explored this in her doctoral research at the University of Agder.

26 Aug 2025

Unlocking neuroglia’s potential to halt neurodegeneration and restore brain homeostasis

In a revealing Genomic Press Interview published today in Brain Medicine, Professor Alexei Verkhratsky dismantles decades of neuroscience orthodoxy with discoveries that position neuroglia as active architects of brain function rather than passive cellular bystanders.

26 Aug 2025

Common painkillers ibuprofen and paracetamol found to fuel antibiotic resistance

Ibuprofen and paracetamol are common over-the-counter medications that many of us reach for when we're sick. But new research from the University of South Australia shows that these trusted staples are quietly fuelling one of the world's biggest health threats: antibiotic resistance.

25 Aug 2025

Researchers discover why smoking tobacco helps people with ulcerative colitis

Researchers led by Hiroshi Ohno at the RIKEN Center for Integrative Medical Sciences (IMS) in Japan have discovered why smoking tobacco helps people suffering from ulcerative colitis, a chronic disease typified by inflammation of the large intestine.

25 Aug 2025

Many people unaware that knee and groin pain could signal hip problems

Having a hard time bending over to put your shoes on? Experiencing pain in the knees, groin, thigh or back? A new survey by The Ohio State University Wexner Medical Center reveals many people don't realize these symptoms can mean there's a problem in the hip.

25 Aug 2025

Shame linked to lower quality of life in people with gut disorders

Feelings of shame are linked to reduced quality of life - as shown by the first study to measure shame as a factor influencing the connection between chronic gastrointestinal disorders and mental health.

25 Aug 2025

How a single gene reshapes pain perception through polyamine signaling

Researchers have identified SLC45A4 as a neuronal polyamine transporter genetically linked to human chronic pain. Loss of this gene in mice disrupts polyamine balance, alters spinal GABA levels, and reduces heat and tonic pain sensitivity.

24 Aug 2025

iconPCR™: Powering the next wave of metagenomics and microbiome discovery

The landscape of metagenomics and microbiome research is evolving at breakneck speed. As sequencing technologies improve and the demand for high-resolution, bias-free microbial data grows, the bottleneck is shifting from sequencing itself to the quality of upstream sample preparation.

From n6 23 Aug 2025

Data-driven approach improves speed and consistency of prosthetic leg fitting

Researchers have developed a new, data-driven way of fitting prosthetic legs which could lead to better fitting prosthetics, in less time and at a lower cost.

22 Aug 2025

Evidence review questions ketamine’s role in chronic pain treatment

A Cochrane review assessed ketamine and other NMDA receptor antagonists for chronic non-cancer pain. The evidence was low to very low certainty, showing no clear pain relief and potential adverse effects with intravenous ketamine.

21 Aug 2025

New study uncovers a surprising mechanism of resistance to immunotherapy

A new international study led by researchers at Moffitt Cancer Center, the Karolinska Institutet and the University of Texas MD Anderson Cancer Center has uncovered a surprising mechanism of resistance to immunotherapy: cancer's ability to injure nearby nerves.

21 Aug 2025

Study shows the brain’s body map remains stable after limb loss

New research from the University of Pittsburgh School of Medicine and Cambridge University upends a long-standing belief about brain plasticity.

21 Aug 2025

Rethinking chronic disease management in older adults

Effectively managing chronic conditions like diabetes and hypertension can greatly improve quality of life, reduce complications and extend longevity for older adults.

20 Aug 2025

Cardiovascular health declines in older adults with heart conditions

U.S. adults, ages 65 and older, with high blood pressure, heart failure or stroke had significant declines in cardiovascular health, according to new research published today in the Journal of the American Heart Association, an open-access, peer-reviewed journal of the American Heart Association.

20 Aug 2025