Pharmacology News and Research

Latest Pharmacology News and Research

Review focuses on autologous cell therapy that can be applied to cardiac surgery

The combination of cell and gene therapy is rapidly raising clinical interest, although their combination has been under investigation for several decades. This is mainly due to the availability and feasibility of clinically relevant gene delivery options. This review focuses on cell therapies for heart failure and their use combined with cardiac surgery as well as with gene therapy.

27 Apr 2016

First small molecule targeted therapy holds promise for Usher syndrome

Usher syndrome (USH) is characterized by hearing loss or deafness at birth and progressive vision loss, and is the most common cause of inherited dual sensory deficit. No treatment is currently available to stop or slow the progression of vision or hearing loss in USH3, one of three clinical classifications for USH that are further divided into subtypes and all associated with different genes.

27 Apr 2016

Resolving HBV infection does not reduce liver cancer risk

Long-term infection with hepatitis B virus (HBV) can cause liver inflammation and increase the risk of liver cancer. Researchers from the US Centers for Disease Control and Prevention, however, found that resolving HBV infection was not associated with reduced rates of liver cancer.

25 Apr 2016

Researchers develop real-time single molecule electronic DNA sequencing platform

Researchers from Columbia University, with colleagues at Genia Technologies, Harvard University and the National Institute of Standards and Technology report achieving real-time single molecule electronic DNA sequencing at single-base resolution using a protein nanopore array.

25 Apr 2016

Scientists develop CRISPRainbow to study genome structure in real time

CRISPRainbow, a new technology using CRISPR/Cas9 developed by scientists at UMass Medical School, allows researchers to tag and track up to seven different genomic locations in live cells. This labeling system, details of which were published in Nature Biotechnology, will be an invaluable tool for studying the structure of the genome in real time.

21 Apr 2016

SI-2 molecule can inhibit tumor growth in breast cancer mouse model

Cancer cells communicate with their environment through cell molecules that pass on signals to the inside of the cell. The signals help cancer cells multiply and migrate, spreading the disease.

21 Apr 2016

Adding CYP24A1 inhibitors may improve antitumor activity of vitamin D

Roswell Park Cancer Institute research on the most potent form of vitamin D, commonly called calcitriol, offers new insights into approaches that may enhance the antitumor activity of this much-studied human hormone.

20 Apr 2016

Newly discovered player in epigenetic regulation closely linked to known cancer promoters

If genes form the body's blueprint, then the layer of epigenetics decides which parts of the plan get built. Unfortunately, many cancers hijack epigenetics to modulate the expression of genes, thus promoting cancer growth and survival.

19 Apr 2016

UNC scientists develop new optogenetic tool to study function of different proteins

Scientists at the University of North Carolina School of Medicine have developed a way to embed light-responsive switches into proteins so that researchers can use lasers to manipulate protein movement and activity within living cells and animals.

19 Apr 2016

Studies confirm benefit of plasma genotyping to predict treatment outcomes for NSCLC patients

The benefit of plasma genotyping to predict treatment benefit in patients with non-small-cell lung cancer (NSCLC) is confirmed in three studies presented today at the European Lung Cancer Conference (ELCC) 2016 in Geneva, Switzerland. Researchers however warned that plasma tests are unlikely to fully replace tissue biopsies.

18 Apr 2016

Proliposomal ropivacaine may offer valuable new option for pain relief

A new "proliposomal" preparation of the local anesthetic drug ropivacaine may provide a valuable new option for pain relief in some clinical situations, with key advantages over other types of slow-release local anesthetics, suggest a pair of reports in Anesthesia & Analgesia.

15 Apr 2016

Scientists aim to develop latest biosensors for personalized medicine, drug development

Scientists at the Leibniz Institute for Molecular Pharmacology in Berlin-Buch and the California Institute of Technology in Pasadena cooperate in the future for the development of the latest biosensors for usage related to personalized medicine and drug development.

14 Apr 2016

Tackling superbugs with antibiotic resistance breakers: an interview with Professor Colin Garner, Chief Executive, Antibiotic Research UK

Superbugs – or to give them their correct name, antibiotic resistant bacteria – arise on repeated exposure to antibiotics. In any population of bacteria there will be a few that are antibiotic resistant (approximately 1 in 100 million bacteria). If these bacteria are allowed to grow and multiply, an antibiotic resistant infection results.

13 Apr 2016

Study reveals TRPV2 protein as new target for chronic pain, cancer treatments

In a recent paper published in Nature Communications, a group of Case Western University School of Medicine researchers presented their discovery of the full-length structure of a protein named Transient Receptor Potential Vanilloid subtype 2 (TRPV2).

13 Apr 2016

Inserm study reveals potential of secondary system to improve heart function

Heart failure affects over one million people in France. Although the blood system is the first to have been explored for the purpose of improving heart function, a study by Inserm has revealed the potential of a secondary system that had previously received scant attention.

13 Apr 2016

New plant-derived oral drug can prevent progression of multiple sclerosis

An international research team has demonstrated that a new plant-derived drug can block the progression of multiple sclerosis (MS).

12 Apr 2016

Pooled analysis from seven clinical studies demonstrates consistent efficacy for ceftazidime-avibactam in the treatment of multi-drug resistant gram-negative bacteria

AstraZeneca has presented positive data demonstrating the efficacy of the investigational antibiotic, ceftazidime-avibactam (CAZ-AVI), in treating patients with ceftazidime-resistant Gram-negative infections, which are increasingly resistant to most available antibiotics, often precipitating the need for clinicians to reach for agents previously reserved for last-line use.

12 Apr 2016

Researchers find evidence that protein involved in regulating inflammation has anti-septic effects

Sepsis represents a serious complication of infection and is one of the leading causes of death and critical illness worldwide due in part to the lack of effective therapies. A report in the American Journal of Pathology provides evidence from both mouse and human studies that SHARPIN, a protein involved in regulating inflammation, has anti-septic effects. These findings may spur development of novel sepsis treatments.

11 Apr 2016

Study reveals new activation mechanism for protein kinases

Protein kinases, most scientists would agree, regulate nearly every aspect of cell life. It is no surprise, then, that having faulty protein kinases may lead to a number of human conditions, including cardiovascular diseases, cancer and diabetes.

11 Apr 2016

Compound from unique blue-green algae could be key to next anti-cancer drug

Could a slippery glob of algae hold the key to the next anti-cancer drug? According to new research into a compound produced by a unique community of blue-green algae, the answer could be yes.

7 Apr 2016

Pharmacology News and Research

Latest Pharmacology News and Research

Review focuses on autologous cell therapy that can be applied to cardiac surgery

First small molecule targeted therapy holds promise for Usher syndrome

Resolving HBV infection does not reduce liver cancer risk

Researchers develop real-time single molecule electronic DNA sequencing platform

Scientists develop CRISPRainbow to study genome structure in real time

SI-2 molecule can inhibit tumor growth in breast cancer mouse model

Adding CYP24A1 inhibitors may improve antitumor activity of vitamin D

Newly discovered player in epigenetic regulation closely linked to known cancer promoters

UNC scientists develop new optogenetic tool to study function of different proteins

Studies confirm benefit of plasma genotyping to predict treatment outcomes for NSCLC patients

Proliposomal ropivacaine may offer valuable new option for pain relief

Scientists aim to develop latest biosensors for personalized medicine, drug development

Tackling superbugs with antibiotic resistance breakers: an interview with Professor Colin Garner, Chief Executive, Antibiotic Research UK

Study reveals TRPV2 protein as new target for chronic pain, cancer treatments

Inserm study reveals potential of secondary system to improve heart function

New plant-derived oral drug can prevent progression of multiple sclerosis

Pooled analysis from seven clinical studies demonstrates consistent efficacy for ceftazidime-avibactam in the treatment of multi-drug resistant gram-negative bacteria

Researchers find evidence that protein involved in regulating inflammation has anti-septic effects

Study reveals new activation mechanism for protein kinases

Compound from unique blue-green algae could be key to next anti-cancer drug

Pharmaceutical Manufacturing - Industry Focus eBook eBook

Building Bridges to Scalable Allogeneic Cell Therapy

Edoardo Fabini

Reducing polypharmacy through innovative drug formulation technologies

Pharmacology News and Research

Latest Pharmacology News and Research

Pharmaceutical Manufacturing - Industry Focus eBook eBook

Building Bridges to Scalable Allogeneic Cell Therapy

Edoardo Fabini

Reducing polypharmacy through innovative drug formulation technologies

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