Pharmacology News and Research

Latest Pharmacology News and Research

ADDF awards $2.1 million grant for clinical study of cancer drug in Alzheimer's patients

The Alzheimer's Drug Discovery Foundation announces a $2.1 million grant awarded to R. Scott Turner, MD, PhD, of Georgetown University Medical Center to conduct a phase II clinical trial of low-dose nilotinib (marketed as Tasigna for use as a cancer therapy) in patients with Alzheimer's disease.

29 Sep 2016

Bioactive compound from neem plant shows promising effects on prostate cancer

A team of international researchers led by Associate Professor Gautam Sethi from the Department of Pharmacology at the Yong Loo Lin School of Medicine at the National University of Singapore has found that nimbolide, a bioactive terpenoid compound derived from Azadirachta indica or more commonly known as the neem plant, could reduce the size of prostate tumour by up to 70 per cent and suppress its spread or metastasis by half.

29 Sep 2016

Alcohol produces same neural and molecular changes as rapid antidepressant drugs

Can having a few drinks help people with clinical depression feel better? Yes. At least in terms of biochemistry.

28 Sep 2016

Researchers aim to discover new treatments for triple-negative breast cancer

The precision medicine approach involving DNA sequencing to pinpoint specific alterations that can be targeted with anti-cancer therapies is becoming an alternate treatment avenue for those with poor-responding cancers.

28 Sep 2016

Cross-disciplinary concepts may lead to effective, personalised cancer treatments

It is not only tumours and metastases that differ in each type of cancer and each individual sufferer but also receptors in cells.

27 Sep 2016

NIGHTSEA and EMS nominate Dr. Sarah Petersen for 2016 KEY Award

NIGHTSEA, creators and manufacturers of the innovative Stereo Microscope Fluorescence Adapter (SFA), and Electron Microscopy Sciences (EMS) are pleased to award the second annual KEY Award for New Faculty to Dr. Sarah Petersen of Kenyon College.

From NIGHTSEA 24 Sep 2016

Human pluripotent stem cells may revolutionize drug discovery in heart disease

Coaxing stem cells from patients to become heart cells may help clinicians personalize drug treatments and prevent heart-related toxicity.

20 Sep 2016

Study quantifies burden of clinically impactful ADRs in general adult population

In a study of 1000 adult patients with unplanned admission to a tertiary hospital in Singapore, the prevalence of adverse drug reactions (ADRs) at the time of admission was 12.4 percent, and the prevalence of ADRs causing admission to the hospital was 8.1 percent.

19 Sep 2016

UC Irvine study shows how YHS effectively treats different forms of pain

Root extracts from the flowering herbal plant Corydalis yanhusuo, or YHS, has widely used for centuries as a pain treatment. Yet few studies have investigated how it works on different forms of pain, and little is known about its molecular mechanisms.

14 Sep 2016

Study finds South Africans living with HIV more resilient despite chronic pain

When one thinks about chronic conditions that are commonly painful, HIV doesn't typically spring to mind. However, more than 50% of HIV-positive individuals experience a painful condition like headache, chest pain or neuropathy, and that pain is frequently experienced as moderate to severe in intensity.

14 Sep 2016

New study raises safety concerns on clinical use of caspase inhibitors for liver diseases

Many acute and chronic liver diseases, including alcoholic hepatitis, result from apoptotic (programmed) cell death mediated by the enzyme caspase. Caspase inhibitors have therapeutic potential to treat and prevent apoptosis-mediated liver injury, and some are currently in clinical trials.

9 Sep 2016

Triptolide molecule can turn into 'cruise missile' against cancer

More than 20 years ago, a billboard in China piqued the interest of a chemical biologist. It endorsed an extract from the plant known as the “thunder god vine” as an immunosuppressant.

9 Sep 2016

Researchers discover how immune cells transition from silent to merciless killing machines

Neutrophils are the superheroes of the body's immune system. Normally mild-mannered, they travel through the bloodstream until they reach an emergency situation, such as a cut or infection, where they switch into battle-mode to engulf and destroy foreign invaders.

9 Sep 2016

New molecular mechanism may explain pain relieving drug’s diverse benefits

Aspirin's ability to reduce the risk of both cardiovascular disease and colon cancer has been a welcome, yet puzzling, attribute of the pain reliever that has been a mainstay in medicine cabinets for more than 100 years.

7 Sep 2016

Study highlights need for additional systems to report adverse drug reactions in infants

A new study reveals that adverse drug reactions in newborns and infants may be under-reported.

7 Sep 2016

Researchers use unique computational approach to identify promising drug leads for heart diseases

Using a unique computational approach to rapidly sample, in millisecond time intervals, proteins in their natural state of gyrating, bobbing, and weaving, a research team from UC San Diego and Monash University in Australia has identified promising drug leads that may selectively combat heart disease, from arrhythmias to cardiac failure.

6 Sep 2016

JMU scientists crystallize new inhibitory antibodies targeting sclerostin

Osteoporosis particularly affects elderly women: the bone's structure weakens and the risk of suffering fractures rises.

2 Sep 2016

New study provides insights into how regulators support accelerated access to new therapies

It can be challenging for regulators to keep up with advances related to medical drugs and devices. A new analysis and editorial published in the British Journal of Clinical Pharmacology provide insights on how officials are working to support accelerated access to new therapies while also ensuring their safety.

2 Sep 2016

Adenosine may play role in inhibiting REM sleep

The regulation and function of sleep is one of the biggest black boxes of today's brain science.

1 Sep 2016

Research reveals new insights into happy hormone, dopamine

Dopamine is a so-called messenger substance or neurotransmitter that conveys signals between neurons.

1 Sep 2016

Pharmacology News and Research

Latest Pharmacology News and Research

ADDF awards $2.1 million grant for clinical study of cancer drug in Alzheimer's patients

Bioactive compound from neem plant shows promising effects on prostate cancer

Alcohol produces same neural and molecular changes as rapid antidepressant drugs

Researchers aim to discover new treatments for triple-negative breast cancer

Cross-disciplinary concepts may lead to effective, personalised cancer treatments

NIGHTSEA and EMS nominate Dr. Sarah Petersen for 2016 KEY Award

Human pluripotent stem cells may revolutionize drug discovery in heart disease

Study quantifies burden of clinically impactful ADRs in general adult population

UC Irvine study shows how YHS effectively treats different forms of pain

Study finds South Africans living with HIV more resilient despite chronic pain

New study raises safety concerns on clinical use of caspase inhibitors for liver diseases

Triptolide molecule can turn into 'cruise missile' against cancer

Researchers discover how immune cells transition from silent to merciless killing machines

New molecular mechanism may explain pain relieving drug’s diverse benefits

Study highlights need for additional systems to report adverse drug reactions in infants

Researchers use unique computational approach to identify promising drug leads for heart diseases

JMU scientists crystallize new inhibitory antibodies targeting sclerostin

New study provides insights into how regulators support accelerated access to new therapies

Adenosine may play role in inhibiting REM sleep

Research reveals new insights into happy hormone, dopamine

Industry Focus - Biopharma eBook

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Pharmacology News and Research

Latest Pharmacology News and Research

Industry Focus - Biopharma eBook

Flow chemistry, AI, and NMR: A next-gen approach to scalable API production

Digital pathology and the PathoVerse: A conversation with Dr. Singh

Bioprocess Efficiency with Cell Density Monitoring

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