Pharmacology News and Research

Latest Pharmacology News and Research

Study unravels how cancer medication works in brains of Parkinson's patients

Laboratory analysis from the first arm of a phase II clinical trial testing the use of nilotinib in patients with Parkinson's disease demonstrates precisely how the agent increases levels of dopamine in the brains of study participants, says a research team at Georgetown University Medical Center. Symptoms of Parkinson's, such as motor dysfunction, are a result of a dopamine loss.

13 Mar 2019

Study provides new understanding about blood pressure control in older adults

Until recently, physicians had generally assumed that older adults benefit from keeping their blood pressure below 140/90 mmHg. However, researchers from Charité - Universitätsmedizin Berlin have now found that this assumption does not apply to all patients with high blood pressure.

12 Mar 2019

Researchers identify gene that increases risk of antibiotic reaction

Researchers at Vanderbilt University Medical Center and colleagues have identified a gene that increases the risk for a severe and potentially life-threatening reaction to the commonly prescribed antibiotic vancomycin.

11 Mar 2019

New guidelines on clinical use of life-saving antibiotics

An international panel of the foremost researchers on infectious disease and antimicrobials has formed new guidelines on the use of polymyxins, a class of antibiotics employed as a last resort to treat deadly, drug-resistant bacteria.

11 Mar 2019

Novel drug shows potential to prevent sepsis progression

Research into a new breakthrough therapy in the fight against sepsis has shown that the drug has potential to stop all sepsis-causing bacteria from triggering organ damage in the early stages of the condition.

8 Mar 2019

UCSF scientists develop new strategy for targeting key Parkinson's molecule

UC San Francisco researchers have for the first time developed a strategy for targeting a key molecule implicated in Parkinson's disease, opening up a potential new treatment strategy for the currently incurable movement disorder.

8 Mar 2019

Researchers find potential new target for chronic pain treatment

A research group at Hiroshima University observed a potential new target for chronic pain treatment. Further research using this receptor could lead to new, more effective drugs to use in pain-relieving treatment for chronic pain.

7 Mar 2019

Inflammation in the brain increases side-effects of hypnotic drugs

In a study recently published in the European Journal of Pharmacology researchers at Okayama University show how the presence of inflammation in the brain can increase its sensitivity to benzodiazepines.

7 Mar 2019

Johns Hopkins researchers to present latest findings on TB and HIV at CROI 2019

Johns Hopkins Medicine researchers are attending the annual Conference on Retroviruses and Opportunistic Infections, where they are sharing their latest findings in the ongoing battle against HIV/AIDS and related infectious diseases with other top basic, translational and clinical researchers from around the world.

7 Mar 2019

Preliminary estimation of contaminants and aromatic substances in diapers

The report "Sécurité des couches pour bébé", published by the French Agency for Food, Environmental and Occupational Health & Safety, deals with hazardous substances in disposable panty diapers.

7 Mar 2019

Cholesterol-lowering drugs linked to higher risk for developing type 2 diabetes

Individuals who take cholesterol-lowering statins may be at higher risk for developing high blood sugar levels, insulin resistance, and eventually type 2 diabetes, according to an analysis published in the British Journal of Clinical Pharmacology.

6 Mar 2019

Study sheds new light on early development of embryos

By applying gene analysis to individual cells from early mouse embryos, researchers at Karolinska Institutet in Sweden have discovered previously unknown cellular stages of fetal development from fertilized egg to living being. The study is published in the scientific journal Cell Reports.

5 Mar 2019

Research on mosaic embryos gives new hope to people seeking infertility treatments

Not every embryo contains 46 perfect chromosomes. Some have more, others have fewer. The result is a common abnormality known as aneuploidy, which occurs in as many as 80 percent of human embryos.

5 Mar 2019

Researchers discover mechanism for how male sex steroids sculpt brain development

Researchers at the University of Maryland School of Medicine have discovered a mechanism for how androgens -- male sex steroids -- sculpt brain development. The research, conducted by Margaret M. McCarthy, Ph.D., who Chairs the Department of Pharmacology, could ultimately help researchers understand behavioral development differences between males and females.

4 Mar 2019

Custom-made proteins could result in antibodies that fight HIV

Researchers have developed a new method for the creation of custom-made proteins that can bypass the protective coating of the HIV virus.

28 Feb 2019

Researchers discover new mechanism of bone growth

In a paper published in the journal Nature, an international research team led by researchers at Karolinska Institutet in Sweden report that bone growth in mice takes place in accordance with the same principles as when new cells are constantly produced in blood, skin and other tissue.

27 Feb 2019

Custom-designed proteins may help generate antibodies to inhibit HIV infection

A new way to create proteins that can sneak through HIV's protective coating may be a step toward understanding the key components needed for developing a vaccine for the virus, according to researchers.

27 Feb 2019

New collaboration aims to prevent life-threatening adverse reactions to medications

The University of Arizona College of Medicine - Phoenix and Banner Health are collaborating to prevent life-threatening adverse reactions to medications.

27 Feb 2019

Paying more attention to antibiotic dosing could improve clinical outcomes for CF patients

Children and young adults with cystic fibrosis (CF) whose lung infections were treated with suboptimal doses of antibiotics had fewer changes in lung microbial diversity during the IV treatment, and their microbial diversity levels were higher 30 days later, a multi-institutional study that includes Children's researchers shows.

23 Feb 2019

Big-data analysis finds new link between popular arthritis drug and heart valve calcification

A well-known, four-year study found popular arthritis drug Celebrex no more dangerous for the heart than older drugs in its same classification - commonly called NSAIDs.

23 Feb 2019