Rotavirus is the most common cause of severe diarrhea among children, resulting in the hospitalization of approximately 55,000 children each year in the United States and the death of over 600,000 children annually worldwide. The incubation period for rotavirus disease is approximately 2 days. The disease is characterized by vomiting and watery diarrhea for 3 - 8 days, and fever and abdominal pain occur frequently. Immunity after infection is incomplete, but repeat infections tend to be less severe than the original infection.
Rotavirus Structure and Classification
Rotavirus is an acute infection that can have lethal consequences if left untreated. This article describes the structure and classification of the virus.
In the U.S., our children rarely fall ill to grave infections because they are protected by vaccines.
The interim guidance released by the WHO aims to help health authorities formulate and implement policies on the disinfection of environmental surfaces during the coronavirus disease (COVID-19) pandemic.
Johnson & Johnson researchers working on a vaccine against the coronavirus are "just like the heroes in the hospitals" fighting to save patients, J&J CEO Alex Gorsky said on the "Today" show a few weeks ago.
A research team from the University of Valencia has carried out a study of infection and immunity markers by detecting antibodies in the blood of 7 different genotypes of the rotavirus VP8 protein, the virus that causes infectious diarrhoea, and concludes that more frequent types mainly affect the child population.
Vaccination against rotavirus has led to a significant decrease in hospitalisations and deaths of children due to severe diarrhoea in the Western Pacific region, a new study has found.
A new study from the University of California, Berkeley, published in the journal Nature in April 2020, reports that extending vaccination to all children could help resolve antimicrobial resistance - one of the biggest obstacles to effective healthcare in low-income countries. This is the first study to look at how vaccination is related to the use of antibiotics in low- and middle-income countries.
After eluding researchers for more than 30 years, the VP3 protein of rotavirus has finally revealed its unique structure and function to a team led by scientists at Baylor College of Medicine.
Much remains unknown about how SARS-CoV-2, the virus that causes COVID-19, spreads through the environment.
Rotavirus infection is thought to be a risk factor for type 1 diabetes mellitus (T1DM). The role played by live attenuated rotavirus vaccination in the risk of this condition in children is, therefore, an area of active research. A new study published in the journal JAMA Pediatrics in March 2020 debunks this concern.
On Thursday 26 March, the Liverpool School of Tropical Medicine will bring together high-level representatives from organizations like the World Health Organization and key stakeholders in the private and public sectors along with scientists and doctors.
Diarrheal diseases are a leading cause of death for young children, accounting for nine percent of all deaths worldwide in children under five years of age, with most occurring in children under two years of age.
Mother's milk has been long touted for its salutary effects on the newborn and its ability to shield infants from certain infections.
Researchers at the University of Toronto have discovered how a brief disruption to a molecular pathway in the guts of mice before they are born can compromise adult immunity to a common and often deadly intestinal virus.
Some gastrointestinal viruses need calcium. They need calcium ions to carry out several essential aspects of viral life, such as entry into host cells, genome replication and building new viruses to invade other cells. The cells invaded by viruses also use calcium. They use it as signals to regulate many of the cells' own processes, but viruses can takeover cellular calcium signaling to satisfy their own needs.
A new article published in the journal PLOS Pathogens on October 10, 2019, claims that the common rotavirus may be responsible for the occurrence of type 1 diabetes, a form of diabetes which occurs in children and is due to destruction of the pancreatic islet cells that produce the hormone insulin to normalize blood glucose levels.
Rotavirus infection may play a role in the development of type 1 diabetes, according to a front matter article published October 10 in the open-access journal PLOS Pathogens by Leonard C. Harrison of the University of Melbourne in Australia, and colleagues.
Kathleen Neuzil, MD, MPH, Professor of Medicine and Pediatrics and Director of the Center for Vaccine Development and Global Health at the University of Maryland School of Medicine and Dean E. Albert Reece, MD, PhD, MBA, announced that CVD has been awarded a contract from the National Institute of Allergy and Infectious Diseases, with total funding up to more than $200 million over seven years if all contract options are exercised.
Research by the Department of Microbiology of the University of Valencia, the Institute of Biomedicine of Valencia and the Institute of Agrochemistry and Food Technology of the CSIC has defined the initial interaction of human rotavirus P  (the main cause of gastroenteritis) with the recipients of the intestine.
New data for the March quarter in 2019 revealed the immunization rates for all five-year-old children in the country increased to 94.78 percent from the previous record of 94.67 percent in December 2018.
Scientists have developed a strategy that raises the volume of gut-body communication, paving the way for new interventions to improve human health.