Rotavirus is the most common cause of severe diarrhea among children, resulting in the hospitalization of approximately 55,000 children each year in the United States and the death of over 600,000 children annually worldwide. The incubation period for rotavirus disease is approximately 2 days. The disease is characterized by vomiting and watery diarrhea for 3 - 8 days, and fever and abdominal pain occur frequently. Immunity after infection is incomplete, but repeat infections tend to be less severe than the original infection.
Rotavirus Structure and Classification
Rotavirus is an acute infection that can have lethal consequences if left untreated. This article describes the structure and classification of the virus.
In this study, the researchers not only elucidate the recent bioconjugated nanomaterials for targeted diagnosis of SARS-CoV-2, but they also provide the rationale behind these developments by discussing the mechanisms and approaches.
To monitor the presence of enteric pathogens in imported seafood, the authors of this paper collected a total of 140 seafood samples imported from eight overseas countries from Beijing, Dalian, Shanghai, Guangzhou, and Wuhan seafood markets from June to November 2019.
A new study has focussed on determining the impact of COVID-19 associated interferences with different recovery scenarios for ten vaccine-preventable diseases.
Melissa Blatzer was determined to get her three children caught up on their routine immunizations on a recent Saturday morning at a walk-in clinic in this Denver suburb. It had been about a year since the kids' last shots, a delay Blatzer chalked up to the pandemic.
A team of researchers has explored the possibility of coating surfaces with TiO2 as a tool to inactivate SARS-CoV-2.
A new study describes the partial protection against respiratory infection with SARS-CoV-2 following gut inoculation with a live attenuated virus.
A chronic gut disorder that occurs in regions with poor sanitation disrupts intestinal immune responses and impairs oral vaccine effectiveness in a mouse model of the disease, according to research led by UPMC Children's Hospital of Pittsburgh and University of Pittsburgh School of Medicine scientists.
This study, published in the journal Viruses, indicated that human coronaviruses do not transfer effectively from contaminated hands to contact surfaces without the presence of any organic material.
23 million children missed out on basic vaccines through routine immunization services in 2020 – 3.7 million more than in 2019 - according to official data published today by WHO and UNICEF.
An interesting new study describes the activities of a family of viral enzymes called two-histidine-phosphoesterases (2H-PEs), found in coronaviruses (CoVs) and rotaviruses, as well as a mammalian A-kinase anchoring protein enzyme, AKAP7, that shares the same function. Together called 2’,5’-PEs, these enzymes all break down 2’,5’-oligoadenylate compounds that activate the antiviral enzyme ribonuclease L (RNase L).
A group of researchers at Kannur University reviewed selected papers and in silico work on potential drug leads that could be used to manage COVID-19.
Inoculation with live attenuated vaccines (LAV) such as those used against TB, polio or measles can stimulate the immune system to provide protection against other infectious diseases, including COVID-19, says a new study.
\With the onset of the coronavirus disease 2019 (COVID-19) pandemic, hundreds of millions of people became infected worldwide, including thousands of pregnant women near term. The question of vertical transmission to the infant via the placenta or breast milk was very real, leading to a near-total ban on breastfeeding in this group.
The interiors of nonflowering trees such as pine and ginkgo contain sapwood lined with straw-like conduits known as xylem, which draw water up through a tree's trunk and branches.
In the paper published in the journal Frontiers in Immunology, the researchers noted that since both the respiratory tract and the gastrointestinal mucosa are affected in COVID-19, it is possible that adjunctive therapies that modulate the gut-lung axis.
The study began with the generation of recombinant (r)SA11 rotaviruses, into which segment 7 modified RNAs were introduced. These encoded sequences for the non-structural protein NSP3 and some parts of the viral spike.
As antibiotic use grows in lower-income countries so does antibiotic resistance, says report.
Researchers report on a Chicken-derived antibody against SARS-CoV-2, offering preliminary data on a potential therapeutic for COVID-19 warranting further research.
A new study describes the antiviral activity of oxysterols, or oxidized cholesterol derivatives, against SARS-CoV-2. These occur in nature, and are not only involved in lipid signaling pathways that modulate a host of processes within the body, including the immune response and lipid homeostasis.
A year ago, while many Americans were finishing their holiday shopping and finalizing travel plans, doctors in Wuhan, China, were battling a mysterious outbreak of pneumonia with no known cause.