Severe Acute Respiratory Syndrome News and Research

Latest Severe Acute Respiratory Syndrome News and Research

Study reports persistent SARS-CoV-2 with increasing viral variants in pediatric patients

New research, published on medRxiv preprint server, has reported the effect of prolonged SARS-CoV-2 infection in immunocompromised children and young adults.

4 Mar 2021

SARS-CoV-2 variants do not substantially affect CD4+ and CD8+ T cell responses, study shows

Researchers from California in the United States have conducted a study showing that important adaptive immune responses to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are not affected by four recently emerged variants of the virus.

3 Mar 2021

Study shows lower antibody cross-reactivity after infection with the B.1.1.7 SARS-CoV-2 variant

In a recent research paper currently available on the bioRxiv* preprint server, a diverse group of researchers has examined the immunogenicity of antibodies against the variant B.1.1.7 of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) initially found in the United Kingdom – and revealed diminished recognition and neutralization of either parental strains or the South African variant.

3 Mar 2021

COVID risk to households and teachers from in person schooling

When researchers analyzed the responses of the COVID-19 Symptom Survey in the United States, they found an increased risk of COVID-19 for household members when children had in-person schooling.

3 Mar 2021

Results from phase 2 trial of Novavax recombinant nanoparticle SARS-CoV-2 vaccine

Novavax, Inc., the American vaccine development company, has been developing a recombinant protein nanoparticle COVID-19 vaccine currently termed NVX-CoV2373. The full-length spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is created in a baculovirus vector, which is then inserted into a lipid nanoparticle around 50 nm in diameter.

3 Mar 2021

Genetic variation associated with COVID-19 outcome

Host genetics play a role in disease progression and prognosis. A paper recently uploaded to the preprint server medRxiv by Dubé et al. (1st March 2021) identifies several alleles associated with the gene natriuretic peptide receptor C (NPR3) that may impact disease severity.

3 Mar 2021

Pfizer SARS-CoV-2 vaccine effective from day 11 post 1st vaccination

New research from a team of scientists in Australia finds that the second ‘booster’ dose of the Pfizer-BioNTech vaccine did not increase vaccine efficacy against severe acute respiratory syndrome (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19). The results suggest one dose of the vaccine was sufficient in providing a robust immune response 11 days after inoculation.

3 Mar 2021

UK public health authorities review early data on the effectiveness of Pfizer and AstraZeneca COVID-19 vaccines

A team of UK scientists has recently evaluated the effectiveness of the Pfizer (BNT162b2) and AstraZeneca (ChAdOx1) vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The findings reveal that both vaccines are effective in significantly reducing SARS-CoV-2 infection in older adults and providing long-term protection.

3 Mar 2021

Researchers develop ultrapotent miniproteins that target SARS-CoV-2 receptor-binding domain

Researchers have investigated the effectiveness of a bioengineered miniprotein in protecting against SARS-CoV-2 infection in vivo. The researchers evaluated the miniprotein, LCB1, against SARS-CoV-2-mediated lung disease in human ACE2-expressing transgenic mice.

3 Mar 2021

Obesity may reduce COVID-19 vaccine efficacy, say researchers

A startling indicates that obesity may reduce the immune response to the current COVID-19 vaccines, along with other factors like age and sex. This could have significant implications for vaccination strategies in obese people.

3 Mar 2021

Delayed second dose strategy with mRNA vaccines may reduce COVID-19 mortality, say researchers

An interesting new preprint shows that even if countries are forced to delay the second dose of the current vaccines administered against SARS-CoV-2, to arrest the ongoing COVID-19 pandemic, the cumulative mortality would still fall significantly.

3 Mar 2021

Researchers conduct large meta-analysis of COVID-19’s neurological manifestations

The global spread of the COVID-19 pandemic, caused by SARS-CoV-2, has led to intense interest in the various manifestations of the infection, including its neurological features. A compact summation by researchers across the UK of what is known at present about this facet of the disease is presented in a new paper.

3 Mar 2021

Researchers examine long-term immune responses following COVID-19 across clinically diverse cohort

A new study by researchers at the University of California, San Francisco, discusses the different aspects of long-term immune responses in a wide sample of patients, as well as how they vary in clinical severity and sequelae.

3 Mar 2021

Novel SARS-CoV-2 spike vaccine candidate produces strong neutralizing response in vivo

A new study by researchers at Mahidol University in Bangkok, Thailand, reports a COVID-19 vaccine candidate called HexaPro in producing neutralizing antibodies against the SARS-CoV-2 spike protein in an animal model.

3 Mar 2021

How SARS-CoV-2 proteins affect vascular functionality

The study, published on the pre-print server medRxiv, can pinpoint and isolate how each of the SARS-CoV-2 proteins independently affects the endothelial response and directly gauge endothelial functionality.

3 Mar 2021

Study demonstrates long-term neuropsychological consequences following SARS-CoV-2 infection

The study, published in the pre-print server medRxiv, demonstrates the presence of long-lasting neuropsychological sequelae after COVID-19, regardless of the respiratory disease's severity.

2 Mar 2021

SARS-CoV-2 viremia predicts severe COVID-19 disease outcomes

The SARS-CoV-2 plasma viremia has been linked to severe disease and death in COVID-19 cases in small-scale cohort studies. The current study, published on the pre-print server medRxiv, aimed to study the mechanisms behind this relationship.

2 Mar 2021

Early antibody response predicts COVID-19 outcome

To address this gap, researchers from the U.S. evaluated the timing of antibody production against SARS-CoV-2 in hospitalized patients. They used a highly sensitive multiplexed bead-based immunoassay that allows for early detection of anti-SARS-CoV-2 antibodies. The study is published on the preprint server medRxiv.

2 Mar 2021

Quantifying SARS-CoV-2 viral load in hospitalized patients

A new paper, published on the medRxiv preprint server, investigates the role of subgenomic RNA transcripts in SARS-CoV-2 infection. Earlier, scientists believed that subgenomic RNA could be traceable infective markers to monitor infectivity.

2 Mar 2021

Concerning mutation in New York SARS-CoV-2 should be monitored, warn researchers

Researchers at the New York State Department of Health in the United States have said concerning mutations within the B.1.526 lineage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has recently become prevalent in New York State warrant further monitoring.

2 Mar 2021

Severe Acute Respiratory Syndrome News and Research

Latest Severe Acute Respiratory Syndrome News and Research

Study reports persistent SARS-CoV-2 with increasing viral variants in pediatric patients

SARS-CoV-2 variants do not substantially affect CD4+ and CD8+ T cell responses, study shows

Study shows lower antibody cross-reactivity after infection with the B.1.1.7 SARS-CoV-2 variant

COVID risk to households and teachers from in person schooling

Results from phase 2 trial of Novavax recombinant nanoparticle SARS-CoV-2 vaccine

Genetic variation associated with COVID-19 outcome

Pfizer SARS-CoV-2 vaccine effective from day 11 post 1st vaccination

UK public health authorities review early data on the effectiveness of Pfizer and AstraZeneca COVID-19 vaccines

Researchers develop ultrapotent miniproteins that target SARS-CoV-2 receptor-binding domain

Obesity may reduce COVID-19 vaccine efficacy, say researchers

Delayed second dose strategy with mRNA vaccines may reduce COVID-19 mortality, say researchers

Researchers conduct large meta-analysis of COVID-19’s neurological manifestations

Researchers examine long-term immune responses following COVID-19 across clinically diverse cohort

Novel SARS-CoV-2 spike vaccine candidate produces strong neutralizing response in vivo

How SARS-CoV-2 proteins affect vascular functionality

Study demonstrates long-term neuropsychological consequences following SARS-CoV-2 infection

SARS-CoV-2 viremia predicts severe COVID-19 disease outcomes

Early antibody response predicts COVID-19 outcome

Quantifying SARS-CoV-2 viral load in hospitalized patients

Concerning mutation in New York SARS-CoV-2 should be monitored, warn researchers

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Severe Acute Respiratory Syndrome News and Research

Latest Severe Acute Respiratory Syndrome News and Research

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