T Cell News and Research

Latest T Cell News and Research

SARS-CoV-2 ORF7a mutation limits host immune suppression, finds study

Researchers have identified a high variability in the C-terminal end of ORF7a in SARS-CoV-2 sequences collected from around the globe. They noted that mutations result in a defective suppression of interferon and lowered replication rate.

25 Feb 2021

SNX-5422 could make an effective COVID-19 prophylactic, says study

SNX-5422 is a heat shock protein 90 (Hsp90) inhibitor currently undergoing clinical trials as a cancer therapeutic. A recent study examines the applicability of repurposing the drug towards severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication inhibition.

25 Feb 2021

Research shows effective strategy to target the SARS-CoV-2 spike protein

The virus that causes COVID-19 belongs to the family of coronaviruses, "corona" referring to the spikes on the viral surface. These spikes are not static - to infect cells, they change shapes.

25 Feb 2021

Study reveals molecular details of SARS-CoV-2 interactions with human cells

In order to infect cells, SARS-CoV-2, the virus that causes COVID-19, needs to insert itself into the membrane of human cells. New molecular models show what parts of SARS-CoV-2 are critical for that interaction, revealing new potential drug targets.

25 Feb 2021

Study reports lasting immune response in convalescent COVID-19 patients

Researchers report the cellular immune response of convalescent patients in Germany, who recovered from mild or moderate infection compared to that of healthy people with no history of COVID-19.

25 Feb 2021

Neuroinvasiveness of SARS-CoV-2 shown by viral RNA and inflammation in the brain

A new study describes the results of a macaque study that showed the development of neurological features of inflammation, following infection by SARS-CoV-2.

25 Feb 2021

Study explores individual differences of SARS-CoV-2 infection in ACE2-expressing stem cells

The clinical phenotype of COVID-19, caused by SARS-CoV-2, is remarkable for its wide range of severity among individual patients. Genetic variations are known to mediate part of these differences. To examine these differences, researchers in a new study used human induced pluripotent stem cells (iPSCs) from different genetically diverse individuals. These cells are used to model genetic disease since they contain the donor’s genetic information. Researchers use a panel of iPSCs from over 500 individuals. The researchers preferred undifferentiated iPSCs to reduce the time required to differentiate them, especially since infection is not always reliable.

25 Feb 2021

New hydrogel-based materials show promise for tissue engineering

New hydrogel-based materials that can change shape in response to psychological stimuli, such as water, could be the next generation of materials used to bioengineer tissues and organs, according to a team of researchers at the University of Illinois Chicago.

25 Feb 2021

Insilico Medicine discovers novel preclinical candidate to address idiopathic pulmonary fibrosis

Insilico Medicine has demonstrated a breakthrough in Artificial Intelligence ("AI") and drug discovery -- linking together generative chemistry and biology for the first time -- to discover a novel preclinical candidate addressing idiopathic pulmonary fibrosis ("IPF") and be validated with multiple human cell and animal model experiments.

25 Feb 2021

Researchers discover specific blood biomarker that predicts kidney transplant rejection

Researchers at the University of Pittsburgh School of Medicine have discovered a blood biomarker that predicts kidney transplant rejection with a lead time of about eight months, which could give doctors an opportunity to intervene and prevent permanent damage.

25 Feb 2021

Study reveals key mechanism by which exercise promotes immunity, strengthens bones

Scientists at the Children's Medical Center Research Institute at UT Southwestern (CRI) have identified the specialized environment, known as a niche, in the bone marrow where new bone and immune cells are produced.

25 Feb 2021

New study sheds light on specialized compartments exhibited by Earth's single-celled ancestors

Scientists have long speculated about the features that our long-ago single-celled ancestors might have had, and the order in which those features came about. Bubble-like compartments are a hallmark of the superkingdom to which we, and many other species including yeast, belong.

25 Feb 2021

Process of molecular sorting emerges from combination of two spontaneous mechanisms, indicates study

The eukaryotic cell is the basic unit of animals and plants. At the microscope, it looks highly structured and subdivided in many membrane-bound compartments.

25 Feb 2021

Microchip can help scientists study the regenerative potential of mice heart cells

Baby mice might be small, but they're tough, too. For their first seven days of life, they have the special ability to regenerate damaged heart tissue.

25 Feb 2021

Combination technique can toggle specific genes on and off

The genetic tool CRISPR has been likened to molecular scissors for its ability to snip out and replace genetic code within DNA.

25 Feb 2021

'Miracle poison' can target a variety of different proteins

Researchers prove they can engineer proteins called proteases to find new targets with high selectivity, a critical advance toward potential new treatments for everything from neuro-regeneration to cytokine storm.

25 Feb 2021

High expression of ACE2 receptors in developing ovaries increases SARS-CoV-2 risk

A team of scientists from China collaborated to find if SARS-CoV-2 could also infect the ovary at different developmental stages.

25 Feb 2021

Study: Battery storage can help protect medically vulnerable households

Extreme weather driven by climate change is making power outages more commonplace even as the need for electricity-dependent home health equipment grows.

25 Feb 2021

Lab study of South African SARS-CoV-2 variant and Moderna vaccine: reduced neutralization, but still protective

Researchers from the US recently compared antibody binding and viral neutralization against 2 SARS-CoV-2 variants that emerged in different parts of the world. The researchers used sera from spike mRNA vaccinated and naturally infected individuals against a circulating B.1 variant and the emerging B.1.351 variant. The study is published on the preprint server bioRxiv.

24 Feb 2021

KTH researchers identify 300 proteins that regulate cell division process

With the hope of contributing to the fight against cancer, researchers in Sweden have published a new molecular mapping of proteins that regulate the cell division process - identifying 300 such proteins.

24 Feb 2021

T Cell News and Research

Latest T Cell News and Research

SARS-CoV-2 ORF7a mutation limits host immune suppression, finds study

SNX-5422 could make an effective COVID-19 prophylactic, says study

Research shows effective strategy to target the SARS-CoV-2 spike protein

Study reveals molecular details of SARS-CoV-2 interactions with human cells

Study reports lasting immune response in convalescent COVID-19 patients

Neuroinvasiveness of SARS-CoV-2 shown by viral RNA and inflammation in the brain

Study explores individual differences of SARS-CoV-2 infection in ACE2-expressing stem cells

New hydrogel-based materials show promise for tissue engineering

Insilico Medicine discovers novel preclinical candidate to address idiopathic pulmonary fibrosis

Researchers discover specific blood biomarker that predicts kidney transplant rejection

Study reveals key mechanism by which exercise promotes immunity, strengthens bones

New study sheds light on specialized compartments exhibited by Earth's single-celled ancestors

Process of molecular sorting emerges from combination of two spontaneous mechanisms, indicates study

Microchip can help scientists study the regenerative potential of mice heart cells

Combination technique can toggle specific genes on and off

'Miracle poison' can target a variety of different proteins

High expression of ACE2 receptors in developing ovaries increases SARS-CoV-2 risk

Study: Battery storage can help protect medically vulnerable households

Lab study of South African SARS-CoV-2 variant and Moderna vaccine: reduced neutralization, but still protective

KTH researchers identify 300 proteins that regulate cell division process

Immunology eBook

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T Cell News and Research

Latest T Cell News and Research

Immunology eBook

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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