T Cell News and Research

Latest T Cell News and Research

ACE2-TMPRSS2 profiling indicates tissue vulnerability to SARS-CoV-2 infection

A new study published in April 2020 on the preprint server bioRxiv reports that the different levels of susceptibility of various organs to viral attack by the SARS-CoV-2 virus causing the huge pandemic of COVID-19 sweeping around the world can be predicted from the level of expression of two molecules, the ACE2 receptor, and the TMPRSS2 protein.

20 Apr 2020

Do ACE inhibitors increase SARS-CoV-2 binding to ACE2?

The COVID-19 pandemic has forced clinicians and academicians to intensive research to find evidence for many conventional therapies. A new round-up editorial published in the journal Cardiovascular Research in April 2020 summarizes the current clinical grounds for and against the use of the commonly used angiotensin axis inhibitors in patients with COVID-19.

20 Apr 2020

HIV-1 and influenza antivirals not effective for treating mild-to-moderate COVID-19 cases

An exploratory randomized, controlled study on the safety and efficacy of either lopinavir/ritonavir (LPV/r) or Arbidol--antivirals that are used in some countries against HIV-1 and to treat influenza , respectively--as treatments for COVID-19, the disease caused by the novel coronavirus SARS-CoV-2, suggests that neither drug improves the clinical outcome of patients hospitalized with mild-to-moderate cases of the disease over supportive care.

20 Apr 2020

A novel method for predicting promising antiviral drug or vaccine targets

A novel method to predict the most promising targets for antiviral drugs or vaccines is based on the conformational changes viral glycoproteins go through during the process of recognition and binding to the host cell.

20 Apr 2020

Artificial 'candy canes' block viral entry and infection

Viruses are part of the human experience throughout our lives. They cause lots of different illnesses with the current coronavirus pandemic as just one example.

20 Apr 2020

Male-female cardiac repair differences found in heart failure survival after heart attack

The short-term acute inflammatory response triggered to mend injured cardiac tissue following a heart attack can lead to weakening of the heart's pumping function if the inflammation remains active over the long-term.

20 Apr 2020

Type 2 diabetics secrete too much glucagon when α-cells become insulin resistant

Patients with type 2 diabetes secrete not only too little insulin but also too much glucagon, which contributes to poor blood glucose control.

20 Apr 2020

Study reveals new therapeutic options for multiple sclerosis

Multiple sclerosis is known as "the disease with a thousand faces" because symptoms and progression can vary dramatically from patient to patient.

20 Apr 2020

EMBL researchers create ‘virtual embryo’ for single-cell studies

Researchers from EMBL Heidelberg and from the University of Padua School of Medicine have created the first complete description of early embryo development, accounting for every single cell in the embryo.

20 Apr 2020

A new combinatorial therapy for treatment of liver cancer

In the latest issue of Molecular Therapy, Skoltech and MIT researchers have published a new combinatorial therapy for the treatment of liver cancer.

20 Apr 2020

Research pinpoints potential new therapeutic target for retinal degeneration

Multi-disciplinary work led by researchers from Trinity College Dublin has pinpointed a potential new therapeutic target for treating retinal degeneration. The work has discovered that a protein (SARM1) involved in neuronal cell injury may also have a role in the progression of retinal degeneration.

20 Apr 2020

Activating a braking mechanism against cancer

A team has identified the binding site where drug compounds could activate a braking mechanism against runaway growth of cancer.

20 Apr 2020

Potential new therapies for multiple sclerosis

In every MS patient cells of their body's own immune system migrate to the brain, where they destroy the myelin sheath.

20 Apr 2020

Research will drastically stabilize brain-computer interfaces

Researchers have drastically improve brain-computer interfaces and their ability to remain stabilized during use.

20 Apr 2020

FAU scientists win $1.7 million NIH grant for research on neuroinflammation

Anxiety, depression and cognitive decline are prominent psychopathologies that together affect more than 40 million people in the United States.

20 Apr 2020

Study adds increasing evidence that autoimmunity plays a role in Parkinson's disease

A new study co-led by scientists at the La Jolla Institute for Immunology adds increasing evidence that Parkinson's disease is partly an autoimmune disease. In fact, the researchers report that signs of autoimmunity can appear in Parkinson's disease patients years before their official diagnosis.

20 Apr 2020

New high-throughput approach yields libraries of probes for immunological assays

An immunological test known as a "tetramer assay" can detect T cells in a blood sample that recognize a specific antigen.

20 Apr 2020

New research gives further evidence that autoimmunity plays a role in Parkinson's disease

A new study adds increasing evidence that Parkinson's disease is partly an autoimmune disease.

20 Apr 2020

Remdesivir prevents COVID-19 progression to severe pneumonia, animal study shows

A team of scientists at the National Institute of Allergy and Infectious Diseases, which is part of the U.S. National Institutes of Health, has tested the efficacy of remdesivir, a nucleotide analog prodrug with a broad antiviral activity, as a COVID-19 treatment.

20 Apr 2020

Novel coronavirus mutation could spell trouble for vaccine development

New research shows that the novel coronavirus is undergoing mutations that could make it challenging to develop a vaccine against. There are a few vaccine candidates that are in the making to prevent COVID-19. With a potential for mutation, the vaccines that are being developed now may not work against the emergent mutated strains worry Taiwanese and Australian researchers. The study is titled, “Analysis of the mutation dynamics of SARS-CoV-2 reveals the spread history and emergence of 2 RBD mutant with lower ACE2 binding affinity.”

19 Apr 2020

T Cell News and Research

Latest T Cell News and Research

ACE2-TMPRSS2 profiling indicates tissue vulnerability to SARS-CoV-2 infection

Do ACE inhibitors increase SARS-CoV-2 binding to ACE2?

HIV-1 and influenza antivirals not effective for treating mild-to-moderate COVID-19 cases

A novel method for predicting promising antiviral drug or vaccine targets

Artificial 'candy canes' block viral entry and infection

Male-female cardiac repair differences found in heart failure survival after heart attack

Type 2 diabetics secrete too much glucagon when α-cells become insulin resistant

Study reveals new therapeutic options for multiple sclerosis

EMBL researchers create ‘virtual embryo’ for single-cell studies

A new combinatorial therapy for treatment of liver cancer

Research pinpoints potential new therapeutic target for retinal degeneration

Activating a braking mechanism against cancer

Potential new therapies for multiple sclerosis

Research will drastically stabilize brain-computer interfaces

FAU scientists win $1.7 million NIH grant for research on neuroinflammation

Study adds increasing evidence that autoimmunity plays a role in Parkinson's disease

New high-throughput approach yields libraries of probes for immunological assays

New research gives further evidence that autoimmunity plays a role in Parkinson's disease

Remdesivir prevents COVID-19 progression to severe pneumonia, animal study shows

Novel coronavirus mutation could spell trouble for vaccine development

Immunology eBook

Redefining control and consistency in anaerobic microbiome workflows

AI in Healthcare: How generative tools are transforming clinical practice

The future of automation: Machine learning–driven hepatocyte and organoid counting

T Cell News and Research

Latest T Cell News and Research

Immunology eBook

Redefining control and consistency in anaerobic microbiome workflows

AI in Healthcare: How generative tools are transforming clinical practice

The future of automation: Machine learning–driven hepatocyte and organoid counting

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