Tuberous Sclerosis News and Research

Latest Tuberous Sclerosis News and Research

Pilot program to fight drug-resistant tuberculosis in South African communities examined by New York Times

The New York Times examines a Doctors Without Borders pilot program to fight drug-resistant tuberculosis in South Africa that allows patients to stay in their homes rather than be isolated in hospital during treatment.

30 Jul 2009

Potential new way to treat childhood epilepsy

Rutgers researchers have discovered a potential new way to treat childhood epilepsy using a widely available therapeutic drug.

10 Jun 2009

Rapamycin epilepsy-prevention effect may be widely applicable

A drug with potential to prevent epilepsy caused by a genetic condition may also help prevent more common forms of epilepsy caused by brain injury, according to researchers at Washington University School of Medicine in St. Louis.

1 Jun 2009

Prenatal molecular diagnosis for tuberous sclerosis complex

Geneticists from Boston University School of Medicine (BUSM) have reported the world's first series of cases of prenatal diagnosis for women at risk of having a child with tuberous sclerosis complex (TSC).

2 Mar 2009

Drug rapamycin reverses mental retardation caused by tuberous sclerosis complex

UCLA researchers discovered that an FDA-approved drug reverses the brain dysfunction inflicted by a genetic disease called tuberous sclerosis complex (TSC). Because half of TSC patients also suffer from autism, the findings offer new hope for addressing learning disorders due to autism. Nature Medicine publishes the findings in its online June 22 edition.

23 Jun 2008

Lymphangioleiomyomatosis - potential clues into the treatment and diagnosis

Studies published in the Jan. 10 edition of the New England Journal of Medicine (NEJM) are providing clues into the treatment and diagnosis of LAM, or lymphangioleiomyomatosis, a progressive and deadly lung disease that affects women in their childbearing years.

11 Jan 2008

Chemical first found on Easter Island could treat tuberous sclerosis

A new study has shown promising results in fighting a severe genetic disorder which can create tumours throughout the body.

11 Jan 2008

The drug sirolimus shrinks tumors, improves lung function

The drug sirolimus, normally used to help transplant patients fight organ rejection, may eventually be used as a less invasive treatment for a tumor called angiomyolipomata in patients with who would otherwise face surgery.

10 Jan 2008

New pathway for inflammation-induced cancer

A well-known inflammatory protein spawns an enzyme that inactivates two tumor-suppressing genes, ultimately triggering production of new blood vessels to nourish breast cancer cells, researchers at The University of Texas M. D. Anderson Cancer Center report in the August edition of the journal Cell .

11 Aug 2007

Research on rare women's lung disease may yield insights into common diseases

For many decades, medical research studies focused primarily on men and the results of countless studies were then applied to women.

18 Jun 2007

Advances in epilepsy treatment

Epilepsy and seizures affect 2.5 million Americans, 181,000 new cases of epilepsy are diagnosed every year, and the disorder incurs an estimated $12.5 billion in annual direct and indirect costs.

1 Jun 2007

Translationally controlled tumor protein key to organ growth

When amounts of a small protein called TCTP (translationally controlled tumor protein) are reduced in the cells of fruit flies, they are smaller than normal, indicating that the protein plays a major role in the growth and proliferation of cells, said researchers at Baylor College of Medicine in a report in current issue of the journal Nature.

20 Feb 2007

NYU pediatric neurosurgeon reports on 25 children with tuberous sclerosis

Sadly, none of the treatments for epilepsy - anti-seizure medications, a procedure called vagus nerve stimulation, a special diet - could quell the electrical storms in the young boy's brain.

8 May 2006

New microRNA mechanism for regulating brain function

Non-coding regions of the genome - those that don't code for proteins - are now known to include important elements that regulate gene activity. Among those elements are microRNAs, tiny, recently discovered RNA molecules that suppress gene expression.

18 Jan 2006

Studies explore genetic interactions between two well-known tumor suppressor proteins, PTEN and TSC2

Two papers in the August 1 issue of Genes & Development explore the genetic interactions between two well-known tumor suppressor proteins, PTEN and TSC2.

19 Jul 2005

Harmful chemicals may reprogram gene response to estrogen

New research shows that exposure to harmful chemicals and drugs during critical developmental periods early in life may actually "reprogram" the way certain genes respond to the female hormone estrogen. This genetic reprogramming may determine whether people with a genetic predisposition for a disease actually develop the disease.

1 Jun 2005

Environment factors can interact with genetics to increase disease risk

31 May 2005

A new guideline evaluates the treatment of infantile spasms

A new guideline developed by the American Academy of Neurology and the Child Neurology Society evaluates the treatment of infantile spasms. The guideline is published in the May 25 issue of Neurology, the scientific journal of the American Academy of Neurology.

24 May 2004