Multiple Sclerosis Causes

Multiple sclerosis (MS) is a disease caused by damage to the nerve fibers in the central nervous system. This damage disrupts the signals sent to and from the brain. MS is a progressive disease that worsens over time, eventually leading to death.

The central nervous system comprises the brain, spinal cord and a network of nerves that conduct messages across the body for controlling movements and actions. These nerve fibers are covered by an insulating substance called myelin that protects the nerve and aids the transport of impulses to and from the brain. In MS, this myelin becomes damaged, which interferes with the conduction of nerve signals, which may be slowed or not transported at all.

multiple sclerosisIn multiple sclerosis, the immune system mistakes the protective myelin sheath for a foreign body and mounts an attack against it. Image Credit: Lightspring /

Causes of multiple sclerosis

Multiple sclerosis is an autoimmune disease. Usually, the immune system protects the body against invading microbes or foreign bodies but in autoimmune diseases, the immune system mistakes healthy body tissue for foreign or damaged tissue that needs to be attacked.

In MS, the immune system mistakes the protective myelin sheath for a foreign body and mounts an attack against it. This destroys the myelin, which becomes inflamed in small areas called plaques or lesions of demyelination. As the inflammation subsides, the myelin left behind may be scarred (sclerosis) and the nerve fiber underneath may be damaged.

The exact cause of multiple sclerosis is not clearly understood but both genetic factors and environmental factors seem to play a role in causing the condition.

Multiple sclerosis - causes, symptoms, diagnosis, treatment, pathology

Multiple sclerosis is not classed as a genetic condition because no one gene has yet been identified as causing the condition. However, researchers have shown that individuals with a relative who has had MS are more likely to develop it. Studies have also shown that if a twin develops the condition, the risk of the other twin developing MS is one in four. Research into the contribution of certain gene combinations to the risk of developing MS is ongoing.

Worldwide studies into multiple sclerosis suggest that individuals from countries that lie further north of the equator may be at a greater risk for the condition. Some studies have shown that lack of sunlight and a subsequent lack of Vitamin D may be linked to the incidence of MS.

Some researchers also believe multiple sclerosis may result from viral infection of the nervous system and/or the immune system and the Epstein-Barr virus (EBV) has commonly been implicated as a cause of MS.


Further Reading

Last Updated: Feb 11, 2021

Dr. Ananya Mandal

Written by

Dr. Ananya Mandal

Dr. Ananya Mandal is a doctor by profession, lecturer by vocation and a medical writer by passion. She specialized in Clinical Pharmacology after her bachelor's (MBBS). For her, health communication is not just writing complicated reviews for professionals but making medical knowledge understandable and available to the general public as well.


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