The Size of SARS-CoV-2 Compared to Other Things

The size of any given viral or bacterial particle can provide a useful insight into how these infecting species can wreak havoc on host cells.

SARS-CoV-2 Virus

Image Credit: Kateryna Kon/Shutterstock.com

Size of SARS-CoV-2

Since the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first identified in December of 2019, many infectious disease specialists, as well as researchers for almost every avenue of medicine, have been investigating how this virus spreads to and infects human beings, the wide range of severe health effects it can cause and ultimately what drugs will be able to effectively kill this virus safely.

In addition to mechanistic information, researchers have also evaluated the size and content characteristics of the SARS-CoV-2 particles. Upon analysis of negative-stained SARS-CoV-2 articles by electron microscopy, researchers have determined the diameter of this virus to range between 60 nanometers (nm) to a maximum diameter of 140 nanometers (nm).

In addition to measuring the spherical size of the virus particle, it has also been confirmed that the length of the size tumors that surround the outermost surface of SARS-CoV-2 can vary in length from 9 to 12 nm.

Why does size matter?

Around the world, health officials have agreed that wearing masks can prevent the spread of the virus between individuals. While this may be true, certain masks are considered to be much more effective at minimizing the risk of exposure, particularly N95 masks.

The protective capabilities offered by N95 masks are largely attributed to the masks’ removal of more than 95% of all particles with an average diameter that is 300 nm or less.

In fact, it has been estimated that N95 masks can filter approximately 99.8% of particles that have an average diameter of 100 nm. In this aspect, the size of a virus particle largely determines how individuals can protect themselves and those around them from acquiring SARS-CoV-2.

Knowing the size of a single virus particle can also allow researchers and healthcare providers to infer the amount of virus that individuals are exposed to through different routes.

For example, respiratory droplets are typically 5-10 micrometers (µm) in length; therefore, it can be inferred that an individual who ingests, inhales, or is otherwise exposed to SARS-CoV-2 positive respiratory droplets can be exposed to hundreds or thousands of virus particles which increases the probability of infection.

Respiratory droplets can be transmitted through coughing, sneezing, contact with contaminated surfaces, or even through inhaled aerosols; therefore, each individual must take adequate steps to reduce their exposure to these particles by wearing masks and practicing safe social distance measures.

How does it compare to other viruses?

To date, research has shown that the viruses that have been identified and isolated can range in diameter size from 20 nm to as large as 500 nm. Aside from spherical virus particles like SARS-CoV-2 whose diameters provide information on their sizes, the length of rod- or filament-shaped viruses can measure to as long as 1,000 nm. Comparatively, the largest and most complex virus currently known to man is the

Viruses, particularly those that originate from animals like SARS-CoV-2 can differ greatly in their size. The smallest known animal viruses are icosahedrons, which belong to the Paroviridae and Picornaviridae families and can have a diameter ranging between 20 and 30 nm.

Comparatively, the largest and most complex virus currently known to man is the giant Mimivirus, which has a total particle diameter, of which includes the fibers that extend out from the capsid, of approximately 750 nm.  

Varying Virus Sizes

Image Credit: Meletios Verras/Shutterstock.com

Comparing bacteria and SARS-CoV-2 sizes

The SARS-CoV-2 virus is a much smaller particle when compared to the primary models for bacterial cell biology, of which included Bacillus subtitles, Staphylococcus aureus, Escherichia Colli and Caulobacter crescentus, all of which have a cell volume that ranges from 400 nm to as large as 3 µm.

The large size of such bacterial species often contribute to their diverse reproductive strategies and ultimately maximize their ability to produce and release large offspring.

Everything else

Aside from the usefulness, that size comparisons between viruses and bacteria can provide to researchers, it is also useful to compare the size of SARS-CoV-2 to other objects that are encountered daily.

An ant, for example, has an average size of 5 millimeters (mm), whereas a dust mite is typically 200 µm in size; both of which are much larger than a single SARS-CoV-2 particle.

Comparatively, a human hair has a thickness that is typically in the size range of 60 to 120 µm; while this diameter exceeds that of a typical SARS-CoV-2 virus particle, one can imagine that the size of a single human hair is comparable to the size of as little as 400 SARS-CoV-2 particles to as many as 1,000 particles.

References and Further Reading

Further Reading

Last Updated: Jul 16, 2020

Benedette Cuffari

Written by

Benedette Cuffari

After completing her Bachelor of Science in Toxicology with two minors in Spanish and Chemistry in 2016, Benedette continued her studies to complete her Master of Science in Toxicology in May of 2018. During graduate school, Benedette investigated the dermatotoxicity of mechlorethamine and bendamustine, which are two nitrogen mustard alkylating agents that are currently used in anticancer therapy.

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Comments

  1. VladimirJosephStephanOrlovsky VladimirJosephStephanOrlovsky United States says:

    N95 masks are largely attributed to the masks’ removal of more than 95% of all particles with an average diameter that is 300 nm or less.
    N95 masks can filter approximately 99.8% of particles that have an average diameter of 100 nm
    #1. So, by your Math, N95 can filter smaller particle better ??
    #2.  "300 nm or less." ... so, particle of 2-3 mn (it is less than 300, right?!) can be filtered by N95 with ~ 95% efficiency ??
    #3. Question: Did you graduate school ?? How is you math teacher ??
    -Vladimir Joseph Stephan Orlovsky

    • Ed Hodgkins Ed Hodgkins United States says:

      Smaller particles are affected more so by Brownian motion and are more apt to be captured by nearby thread.  It is therefore logical that the mask would capture smaller objects more efficiently.  None of these things measuring as small as nanometers travel in a directly line.  There are a lot of forces at work.

      • Jake Martin Jake Martin United States says:

        What kind of science and math are they teaching you "geniuses" these days?  Now I can see why so many of today's medical personnel and scientists accept all of the lies coming from the cdc, who, and climate change idiots!

  2. Gregg McKenzie Gregg McKenzie United Kingdom says:

    On any human bacterial cell there are thousands of different receptors, not just for 'Coronavirus' as depicted. Thousands of different types of cellular debris can potentially connect at the cell surface.

    'Covid19' - isn't!

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
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