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Speeding up Alzheimer's research: Progerin turbocharges cellular models for quicker drug screening

The study reveals that introducing progerin, a protein associated with accelerated aging, into cellular models of Alzheimer's Disease (AD) can hasten the development of AD-related traits. This innovative approach offers a more efficient method for studying AD mechanisms, potentially accelerating the discovery of new treatments.

31 Oct 2023

How next-gen sequencing is changing antibody drug discovery

New study outlines how next-generation sequencing (NGS) and machine-learning methods can revolutionize antibody discovery, particularly against SARS-CoV-2. The research demonstrates that NGS provides greater epitopic and paratopic diversity, enabling more effective identification and prioritization of therapeutic antibodies.

31 Oct 2023

Unbiased proteomic analysis reveals fibroinflammatory landscape of the aging ovary

A new priority research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 20, entitled, "Proteomic quantification of native and ECM-enriched mouse ovaries reveals an age-dependent fibro-inflammatory signature."

31 Oct 2023

Using synthetic biology to develop smarter cell therapies for cancer patients

We are embarking on an unprecedented era of therapeutic development enabled by live cell engineering.

31 Oct 2023

Unsupervised genome-wide variant effect predictor based on pretraining of DNA language models

The Genomic Pre-trained Network (GPN), a multispecies model developed to learn genome-wide variant effects.

31 Oct 2023

New MECP2 gene variant identified and characterized in Rett syndrome

Rett syndrome is a rare devastating neurological disorder that primarily affects young girls and manifests as an impaired ability to walk and talk, along with characteristic 'hand-wringing' movements, seizures, and cognitive disability.

30 Oct 2023

UQ's drug discovery facility opens to researchers nationwide after $1.9M funding injection

The University of Queensland's small molecule drug discovery facility will open its doors to researchers from across Australia for the first time thanks to a National Collaborative Research Infrastructure Strategy (NCRIS) funding injection.

30 Oct 2023

UTA bioengineer receives NIH grant to develop high-resolution imaging system to quantify cell tracking

The ability to dynamically track the movement of cells is essential for modeling cellular interactions as they form organs such as the heart. But current microscope technology isn't up to the task of capturing those movements.

30 Oct 2023

Resident Tregs found to remain in certain lymph nodes for a long time

The immune system is fast when it comes to fighting viruses, bacteria and other pathogens. But it also has to know when not to attack - for example, harmless substances such as pollen or house dust, which otherwise trigger allergic reactions.

30 Oct 2023

University of Oklahoma scientist secures nearly $1 million award to advance research in computational genomics

Marmar Moussa, Ph.D., an assistant professor of computer science professor at the University of Oklahoma, has secured a nearly $1 million award from the National Institutes of Health to advance her work in computational genomics.

30 Oct 2023

Short-chain fatty acids produced by intestinal bacteria play role in dendritic cell elongation

Dendritic cells play a key role in the mammalian immune system. These cells are present throughout the human body and are known to capture foreign bodies, i.e., antigens, using extendable "arms" called dendrites.

30 Oct 2023

Study uncovers interplay of lifestyle choices and DNA methylation in gastric neoplasia risk

A new paper in The Lancet eBioMedicine explores whether these changes predict the future risk of stomach tumors and how epigenetic changes interact with environmental and lifestyle factors in this process.

30 Oct 2023

New bivalent vaccine shows promising results against key fish pathogens

The efficacy of a bivalent vaccine against Aeromonas hydrophila (A. hydrophila) and Streptococcus agalactiae (S. agalactiae).

30 Oct 2023

Decoding how the brain understands sentences in real-time

Researchers examine how the brain processes language by using intracranial recordings in epilepsy patients during reading tasks, revealing the neural networks responsible for semantic integration and distinguishing between semantic coherence and task-based referentiality. The study pinpoints specific brain regions activated during sentence processing and offers new insights into the spatiotemporal dynamics of language understanding.

29 Oct 2023

Life Science News

Speeding up Alzheimer's research: Progerin turbocharges cellular models for quicker drug screening

How next-gen sequencing is changing antibody drug discovery

Unbiased proteomic analysis reveals fibroinflammatory landscape of the aging ovary

Using synthetic biology to develop smarter cell therapies for cancer patients

Unsupervised genome-wide variant effect predictor based on pretraining of DNA language models

New MECP2 gene variant identified and characterized in Rett syndrome

UQ's drug discovery facility opens to researchers nationwide after $1.9M funding injection

UTA bioengineer receives NIH grant to develop high-resolution imaging system to quantify cell tracking

Resident Tregs found to remain in certain lymph nodes for a long time

University of Oklahoma scientist secures nearly $1 million award to advance research in computational genomics

Short-chain fatty acids produced by intestinal bacteria play role in dendritic cell elongation

Study uncovers interplay of lifestyle choices and DNA methylation in gastric neoplasia risk

New bivalent vaccine shows promising results against key fish pathogens

Decoding how the brain understands sentences in real-time

Receptor structure-based virtual screening identifies a promising p38α inhibitor

Eppendorf & Science Prize for Neurobiology awarded to Marissa Scavuzzo for glial cell research

Genetics and sedimentology combined to refine cyanobacteria biomarker diagnostics

Common chemical label shields proteins from degradation

Novel replacement strategy holds promise for the treatment of various genetic disorders

AI-designed drug candidate shows promise for gastric acid inhibition

How innovation in dried blood spot testing is transforming neurological disease monitoring

Unlocking live single-cell functional insights

Fluidics in Modern Healthcare & Medical Device Innovation

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