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New metagenomic study reveals global landscape of antimicrobial resistance

There are large geographical differences in both how frequently resistant genes occur and in which types of bacteria the genes are found.

1 Dec 2022

Harmful gut bacteria co-opt a genetic susceptibility to trigger Crohn’s disease

Changes in a single gene open the door for harmful gut bacteria to set off the inflammation that drives Crohn’s disease, according to a new study led by Weill Cornell Medicine and NewYork-Presbyterian investigators.

1 Dec 2022

Integrated approach addresses some of the biggest challenges in natural products drug discovery

Many successful drugs have their origins in natural sources such as plants, fungi, and bacteria, but screening natural products to identify potential drugs remains a difficult undertaking.

1 Dec 2022

Study implicates a specific type of brain cell as key player underlying the impact of stressors

More than 70% of adults will experience at least one traumatic experience, such as a life-threatening illness or accident, violent assault or natural disaster, in their lifetimes and nearly a third will experience four or more, according to global data.

1 Dec 2022

Early life experiences can affect gene activity more than half a lifetime later

Early life experiences can impact the activity of our genes much later on and even affect longevity, finds a new study in fruit flies led by UCL researchers.

1 Dec 2022

Metrion Biosciences invests in new High Throughput Screening capability and expanded facilities

Metrion Biosciences Limited (“Metrion”), the specialist ion channel contract research and drug discovery company, today announced the launch of its High Throughput Screening (HTS) capability, as well as the expansion of its state-of-the-art lab and office facilities. Scott Maidment has been appointed as Head of HTS to lead the new service.

From Metrion Biosciences Limited 1 Dec 2022

Hyperactivated brain cells following social trauma impair social reward and promote social avoidance

Past social trauma is encoded by a population of stress/threat-responsive brain cells that become hyperactivated during subsequent interaction with non-threatening social targets. As a consequence, previously rewarding social targets are now perceived as social threats, which promotes generalized social avoidance and impaired social reward processing that can contribute to psychiatric disorders, according to a study conducted by researchers at the Brain and Body Research Center at Mount Sinai and published November 30 in Nature.

30 Nov 2022

Study provides a framework to guide the development of variant-resistant SARS-CoV-2 vaccines

Latest research findings show that vaccine-elicited neutralizing antibodies against SARS-CoV-2 are mostly directed against one of the two main domains of the viral entry machinery.

30 Nov 2022

Study reveals key details of how DREADD technology highjacks neuronal activity

Understanding of how neuronal activity modulates brain function is a key first step towards creating more effective drugs to treat a variety of neuropsychiatric illnesses, including depression, anxiety, schizophrenia, substance abuse, epilepsy, and others.

30 Nov 2022

Study suggests new strategies for making cartilage cells

As any weekend warrior understands, cartilage injuries to joints such as knees, shoulders, and hips can prove extremely painful and debilitating. In addition, conditions that cause cartilage degeneration, like arthritis and temporomandibular joint disorder (TMJ), affect 350 million people in the world and cost the US public health system more than $303 billion every year.

30 Nov 2022

SARS-CoV-2 can cause hyperglycemia in cats

In a recent study published in The Journal of Infectious Diseases, researchers explored the association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and hyperglycemia in cats.

30 Nov 2022

Removal of cilia from the brain's striatum impairs time perception and judgment, study finds

Researchers at the University of California, Irvine have discovered that removal of cilia from the brain's striatum region impaired time perception and judgment, revealing possible new therapeutic targets for mental and neurological conditions including schizophrenia, Parkinson's and Huntington's diseases, autism spectrum disorder, and Tourette syndrome.

30 Nov 2022

Understanding how the gut mycobiota respond to antibiotic treatment

Antibiotic treatment disrupts the balance of beneficial and harmful bacteria in a person's gut. That disruption can lead to the overgrowth of fungal species in the gut mycobiota, including the common intestinal yeast Candida albicans.

30 Nov 2022

Human fetal cerebellar cell atlas reveals the origin of aggressive medulloblastomas

Studying mice has filled encyclopedias with breakthrough medical discoveries. But when it comes to brain cancers, the little rodents have long exhibited fundamental limitations.

30 Nov 2022

Stem cell crosstalk with the microenvironment creates a loop of tumor-promoting factors

What drives tumor growth? Is it a few rogue cells imposing their will upon healthy tissue, or diseased tissue bringing out the worst in otherwise peaceable cells? Or is it a back-and-forth, a dialogue between the two?

30 Nov 2022

Scientists discover how an enzyme involved in DNA repair becomes vital to tumor survival

Scientists at the Francis Crick Institute, in collaboration with Artios, have identified how an enzyme involved in DNA repair (POLQ), becomes vital to the survival of certain cancers, if the cancer cells lose the ability to use a more common method of DNA repair.

30 Nov 2022

Inactivation of previously unknown gene found to be a likely culprit in the onset of pancreatic cancer

New research out of VCU Massey Cancer Center points to the inactivation of a previously unidentified gene as a likely culprit in the development of pancreatic cancer.

30 Nov 2022

Fingerprint-embedding framework can help find novel drug candidates

Researchers have developed a new computer framework that holds promise in the work to discover new drugs. Their framework uses an artificial intelligence method called convolutional neural network to provide global information about potential novel drug candidates.

30 Nov 2022

Research finds higher rate of rare tandem repeats in the genomes of individuals with schizophrenia

In our cells, the language of DNA is written, making each of us unique. A tandem repeat occurs in DNA when a pattern of one or more nucleotides – the basic structural unit of DNA coded in the base of chemicals cytosine (C), adenine (A), guanine (G) and thymine (T) – is repeated multiple times in tandem. An example might be: CAG CAG CAG, in which the pattern CAG is repeated three times.

30 Nov 2022

New urinary biomarkers could help monitor potential abuse of emerging synthetic cannabinoids

A team of scientists from the National University of Singapore (NUS) has successfully identified the urinary biomarkers of an emerging subclass of synthetic cannabinoids, called OXIZID, to monitor potential abuse.

30 Nov 2022

Life Science News

New metagenomic study reveals global landscape of antimicrobial resistance

Harmful gut bacteria co-opt a genetic susceptibility to trigger Crohn’s disease

Integrated approach addresses some of the biggest challenges in natural products drug discovery

Study implicates a specific type of brain cell as key player underlying the impact of stressors

Early life experiences can affect gene activity more than half a lifetime later

Metrion Biosciences invests in new High Throughput Screening capability and expanded facilities

Hyperactivated brain cells following social trauma impair social reward and promote social avoidance

Study provides a framework to guide the development of variant-resistant SARS-CoV-2 vaccines

Study reveals key details of how DREADD technology highjacks neuronal activity

Study suggests new strategies for making cartilage cells

SARS-CoV-2 can cause hyperglycemia in cats

Removal of cilia from the brain's striatum impairs time perception and judgment, study finds

Understanding how the gut mycobiota respond to antibiotic treatment

Human fetal cerebellar cell atlas reveals the origin of aggressive medulloblastomas

Stem cell crosstalk with the microenvironment creates a loop of tumor-promoting factors

Scientists discover how an enzyme involved in DNA repair becomes vital to tumor survival

Inactivation of previously unknown gene found to be a likely culprit in the onset of pancreatic cancer

Fingerprint-embedding framework can help find novel drug candidates

Research finds higher rate of rare tandem repeats in the genomes of individuals with schizophrenia

New urinary biomarkers could help monitor potential abuse of emerging synthetic cannabinoids

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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