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New method for 3D culture accurately quantifies how cancer cells generate forces to spread within tissue

Research to understand how cancers grow and spread has conventionally been done on two-dimensional, flat cultures of cells, which is very different to the three-dimensional structure of cells in the body.

12 Aug 2022

Experts urge FDA to include T cell responses when evaluating COVID vaccines

Now, a group of prominent scientists and physicians are urging the FDA to include in its guidance to vaccine developers a recommendation for T-cell assessment in COVID-19 vaccine clinical trials to more comprehensively measure immune response.

11 Aug 2022

Vaccines and monoclonal antibodies being developed for respiratory syncytial virus

A new study reviews recent advancements made in the development of RSV immunoprophylactic measures.

11 Aug 2022

New evidence explains why thinking hard makes one feel worn out

It's no surprise that hard physical labor wears you out, but what about hard mental labor? Sitting around thinking hard for hours makes one feel worn out, too.

11 Aug 2022

New gel-based cartilage substitute is stronger and more durable than the real thing

Over-the-counter pain relievers, physical therapy, steroid injections -- some people have tried it all and are still dealing with knee pain.

11 Aug 2022

Elevated acetate levels reprogram gut microbiota during alcohol intake

Chronic alcohol use is a major cause of liver damage and death: Approximately 30,000 persons in the United States die annually from alcoholic liver diseases, such as cirrhosis.

11 Aug 2022

Recombination most often occurs on the COVID-19 phylogenetic tree in the form of 'long branches'

An analysis of millions of SARS-CoV-2 genomes finds that recombination of the virus is uncommon, but when it occurs, it is most often in the spike protein region, the area which allows the virus to attach to and infect host cells.

11 Aug 2022

Newly designed nanoparticles target the body’s immune cells to turn them against cancer

Scientists of the department of Advanced Organ Bioengineering and Therapeutics (Faculty of S&T, TechMed Centre) recently published a novel cancer immune therapy in the scientific journal Nature Communications.

11 Aug 2022

Novel model reveals how genomic instability arises in histologically benign tissue

Understanding which cells give rise to which areas of cancer can improve our understanding of how a tumor has grown and developed, including how it has changed genetically, over time. This has been made possible using a new technique called spatial transcriptomics, which allows scientists to see what genetic changes take place without breaking up the tissue they're looking at.

11 Aug 2022

Interferon beta reduces binding of three components to RBCs, study finds

Drugs called interferon betas are common treatments for multiple sclerosis (MS), reducing relapses and slowing motor function decline. Interferon beta, a protein known to contain a zinc binding pocket, is thought to reduce proinflammatory molecules and even increase production of anti-inflammatory species in MS patients.

11 Aug 2022

Nearly three-quarters of all stem cell lines are affected by DNA damage, say researchers

DNA damage caused by factors such as ultraviolet radiation affect nearly three-quarters of all stem cell lines derived from human skin cells, say Cambridge researchers, who argue that whole genome sequencing is essential for confirming if cell lines are usable.

11 Aug 2022

Study quantifies the prognostic accuracy of two protein biomarkers

Blood tests taken within 24 hours of a traumatic brain injury (TBI) flag which patients are likely to die and which patients are likely to survive with severe disability, according to a study headed by UC San Francisco, the University of Pennsylvania and the University of Michigan. Their results -- available within minutes -- may confirm the need for prompt surgical interventions or may help guide conversations with families in cases of devastating injury.

11 Aug 2022

Gene expression in male and female brains become more similar with age, study says

When male and female fruit flies age, their brains become desexualized. Age-related changes take place in both sexes, but the male brain becomes feminized to a larger extent than the female brain becomes masculinized. This is the conclusion of a study performed by a research group at Linköping University. The findings are published in the journal Proceedings of the Royal Society of London B.

11 Aug 2022

New computation-guided approach to identify small molecule corrector drugs for p53 hotspot mutations

A new study, led by researchers from the University of California, Irvine and the University of California, San Diego, reveals a new computation-guided approach to identify small molecules that can restore aspects of wild-type p53 tumor suppression function to mutated p53, which play an important role in many human cancers.

11 Aug 2022

New compound proves to be potent against more than 300 drug-resistant bacteria

Urinary tract infections are common, yet are increasingly tough to treat because the bacteria that cause them are becoming resistant to many antibiotics.

10 Aug 2022

UTSW scientists discover mechanism of RNA capping by SARS-CoV-2 virus

A team led by UT Southwestern researchers has identified how SARS-CoV-2, the virus that causes COVID-19, builds a structure called the RNA cap that's critical for successful viral replication.

10 Aug 2022

Study finds genetic alterations in healthy cells that match with the tumor cells

A new study offers the possibility of unmasking genetic mutations in an organ well before commonly-used screening techniques detect signs of cancer.

10 Aug 2022

Linkam puts cryo in the spotlight at M&M 2022

Market leader in temperature and environmental-controlled microscopy, Linkam, presented its range of cryo workflow solutions and sample characterisation tools at Microscopy and Microanalysis (M&M) 2022.

From Linkam Scientific Instruments 10 Aug 2022

IRB scientists identify critical spots on the genome where gene editing could cause an unwanted response

CRISPR/Cas9 is a commonly used, very precise, gene editing technique whose development, by Jennifer A. Doudna and Emmanuelle Charpentier, was recognised with the 2020 Nobel Prize in Chemistry. Commonly known as "genetic scissors", CRISPR allows the introduction of the desired DNA sequence into (virtually) any spot of the genome, thus modifying or inactivating a gene. This technique is widely used in biomedical research and some CRISPR-based therapies are in clinical trials for the treatment of human blood disorders, some types of cancer and HIV, among other conditions.

10 Aug 2022

Senate Commission’s position paper makes a timely contribution to the ongoing debate on animal experimentation

The DFG's Permanent Senate Commission on Animal Protection Experimentation has published a detailed "Position Paper on Ensuring High-Performance Biomedical Research While Maintaining the Highest Animal Welfare Standards".

10 Aug 2022

Life Science News

New method for 3D culture accurately quantifies how cancer cells generate forces to spread within tissue

Experts urge FDA to include T cell responses when evaluating COVID vaccines

Vaccines and monoclonal antibodies being developed for respiratory syncytial virus

New evidence explains why thinking hard makes one feel worn out

New gel-based cartilage substitute is stronger and more durable than the real thing

Elevated acetate levels reprogram gut microbiota during alcohol intake

Recombination most often occurs on the COVID-19 phylogenetic tree in the form of 'long branches'

Newly designed nanoparticles target the body’s immune cells to turn them against cancer

Novel model reveals how genomic instability arises in histologically benign tissue

Interferon beta reduces binding of three components to RBCs, study finds

Nearly three-quarters of all stem cell lines are affected by DNA damage, say researchers

Study quantifies the prognostic accuracy of two protein biomarkers

Gene expression in male and female brains become more similar with age, study says

New computation-guided approach to identify small molecule corrector drugs for p53 hotspot mutations

New compound proves to be potent against more than 300 drug-resistant bacteria

UTSW scientists discover mechanism of RNA capping by SARS-CoV-2 virus

Study finds genetic alterations in healthy cells that match with the tumor cells

Linkam puts cryo in the spotlight at M&M 2022

IRB scientists identify critical spots on the genome where gene editing could cause an unwanted response

Senate Commission’s position paper makes a timely contribution to the ongoing debate on animal experimentation

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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