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The delivery of drugs and diagnostic markers to cancer tissues has been a major challenge in the development of cancer therapies. Typical delivery methods distribute products throughout the body, affecting healthy and cancerous cells, thereby toxic effects to healthy cells limit the scope and effectiveness of the anticancer therapy.
Deoxyribonucleic acid (DNA) has a unique structure and stability, making it an amazingly versatile molecule. This molecule plays a critical role in the biological world as it encodes and passes on all inheritable genetic information to subsequent generations.
Pantanowitz also cautions that digital workflows must be executed properly, and this starts with the successful digitization of glass slides by means of whole slide scanning.
Drug delivery systems are technologies used to ensure the safe and effective transport of a drug around the body and its release at the desired site of action. They incorporate a range of approaches and methodologies designed to modify the drug distribution and availability in order to optimize a drug's efficacy and safety profile.
To offset the positional errors between F-d and topographical data, PinPoint™ Nanomechanical mode was developed and implemented in the operation software.
AFM is extensively used to characterize the collagen’s mechanical properties, morphology, and in-situ self-assembly processes.
With PinPoint™ Nanomechanical mode, a quantifiable elasticity map that previously took days to generate can now be obtained within an hour.
Aggregation of both synthetic and biological materials is a great concern, posing problems at different stages of the discovery and formulation processes. The capability to identify and characterize aggregates is of broad utility, and the experiments discussed in this article demonstrate the ability of the nanoparticle tracking analysis (NTA) technique, that is one of a kind, to comprehend the dynamics of aggregation in a biological system through high resolution particle-by-particle analysis.
This article shows how a combination of nanoparticle tracking analysis (NTA) technique and a gold labeling method can be used to rapidly measure the concentration and size of Adeno-Associated Virus (AAV).
Mid‐infrared chemical imaging is a quantitative, non‐destructive microscopy method that can be used to visualize intrinsic biochemical markers in cells.
The use of nanoparticles in diagnostic and therapeutic applications has expanded in recent years, thanks largely to technological advancement and the growth of research devoted to the topic.
Gastric cancer is a “silent killer”. Having few early symptoms, it is typically not diagnosed until it has reached an advanced stage.Like colon and ovarian cancer, which are also challenging to diagnose at early stages...
Most biotherapeutic molecules include either proteins or protein derivatives, with monoclonal antibodies (mAbs) representing the largest group of biopharmaceuticals on the market.
Epigenetics refers to the study of heritable changes that occur in gene expression. Such changes are induced by non-genetic mechanisms, without causing any change in the DNA sequence or gene structure.
The 3View® system is an advanced three-dimensional electron microscopy (3DEM) system that has been designed to conduct serial SBFSEM.
Electron energy loss spectroscopy (EELS) is used to analyze the energy distribution of the electrons that are passing through a thin sample.
Surface plasmon resonance (SPR) is a popular label-free technology that helps scientists study the binding interactions between two biomolecules in a quantitative manner.
Understanding neurite dynamics is essential to study neuronal differentiation, embryonic development, neuronal injury and regeneration, and neuropathological disorders.
Cell migration is a basic constituent of various pathological and biological processes, such as tissue re-organization, embryonic development, angiogenesis, tumor metastasis, immune cell trafficking, and chronic inflammation.
Continuous live-cell monitoring techniques have witnessed a significant development in recent years, transforming the way cells are used in the laboratory.