Life Science White Papers

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Life Science White Papers are in-depth articles aimed to educate and inform site visitors interested in life science research. Some of these papers are derived from sources where we have existing commercial relationships. Such articles are clearly labelled as sponsored content and are only accepted when the content is deemed to add value to the core editorial ethos of News Medical.

Harnessing the power of CRISPR through accurate sample prep

CRISPR technology burst onto the scene in 2012,1 and has been a staple of scientific research ever since. CRISPR offers the promise of personalized medicine on a level previously unattainable, and clinical trials are already underway using the technology in China.

From Vitl Life Science Solutions 25 Jul 2017

Using NanoBiT® Technology to Study the Dynamics of Protein Interactions in Live Cells

NanoLuc® Binary Technology, also known as NanoBiT, is an innovative binary complementation solution built on NanoLuc® Luciferase (1).

From Promega Corporation 24 Jul 2017

Normalization: An Essential Part of Bioluminescent Reporter Assay

There are types of experimental methods that often use normalization to fix the differences induced by factors other than what is immediately being analyzed.

From Promega Corporation 24 Jul 2017

Using Calorimetric Methods to Investigate Protein Misfolding and Aggregation

Under the right physiological conditions for gain of function, unfolded proteins can fold into native structures that are thermodynamically-favorable, as illustrated in Figure 1. Native structures are stabilized and solubility is ensured as a result of embedded hydrophobic regions within the protein's interior and also the fact that hydrophilic residues are exposed to aqueous solutions.

From Malvern Panalytical 20 Jul 2017

Using Dynamic Light Scattering to Screen Colloidal Aggregates of Small-Molecule Drugs

It is an extremely tedious task to identify new small-molecule drugs through high-throughput screening (HTS). As a result, engineers and scientists have collaborated to automate the entire process of trudging through indefinite number of compounds, evaluating their binding to proteins of interest and searching for the few precious compounds that indeed bind.

From Waters | Wyatt Technology 19 Jul 2017

Rapid Sample Transfer Between Differing Labware Formats

Multichannel pipettes have become a ubiquitous liquid handling tool for molecular biology and biochemical assays in life science laboratories.

From INTEGRA Biosciences 17 Jul 2017

Real Time Measurement of Tumor Cell Death Using IncuCyte® Immune Cell Killing Assay

This protocol provides an overview for measuring immune cell killing of adherent or non-adherent tumor cells in real time. The highly flexible co-culture assay format is amenable to both antibody-dependent cell-mediated cytotoxicity (ADCC) and cytotoxic T-cell killing, two mechanisms of cell-mediated immune response.

From Sartorius 10 Jul 2017

Applying IncuCyte® Apoptosis Assay for the Fluorescent Detection of Caspase-3/7 Activation or Phosphatidylserine Externalization

This protocol describes the IncuCyte® Apoptosis Assay methodology that enables real-time detection of apoptosis using mix-and-read IncuCyte® Caspase 3/7 or Annexin V Reagents. The method can be used with the IncuCyte® Live-Cell Analysis System using any type of treatment and cell type.

From Sartorius 27 Jun 2017

Applications of Scanning Electron Microscope in Pharmaceutical Research Field

Pharmaceutical research involves creation of new drugs or continuous improvement of existing drugs. This versatile research topic is a broad field of study dealing with an increasing number of challenges, owing to new pathogens emerging constantly and known pathogens becoming increasingly resistant to existing drugs.

From Thermo Fisher Scientific Phenom-World BV 27 Jun 2017

Using INTEGRA VIAFLO 96 System for Analysis of Drugs of Abuse

Prior to LC-MS/MS analysis, sample preparation has to be done to eliminate matrix interferents from urine samples.

From INTEGRA Biosciences 19 Jun 2017

Genome Wide Comparison of N-ChIP and X-ChIP Using Solid State Chromatrap® Spin Column Technology

This article presents a comprehensive genome wide comparison of native and cross linked chromatin immunoprecipitation (ChIP) and next generation sequencing (ChIP-seq) using the patented solid state Chromatrap® spin column technology.

From Chromatrap® - Porvair Sciences Ltd 5 Jun 2017

Using AFM to Visualize Lipid Content in Stratum

In this article, the variable lipid content present in stratum corneum is visualized and compared at high spatial resolution using atomic force microscopy (AFM).

From Bruker Nano Surfaces and Metrology 31 May 2017

Using CLARIOstar® Microplate Reader for Real-Time Detection of Gi and Gs Signaling in Living Cells

Toward the end of these drug screenings, positive hits have to be confirmed in living cells related to disease, for example, iPSC derived cell lines.

From BMG LABTECH GmbH 25 May 2017

Smart temperature control enhances PCR sample preparation

Who said you can’t teach and old dog new tricks? Latest advancements say otherwise One of the most widely used techniques in molecular biology is polymerase chain reaction (PCR), a method used to amplify small sections of DNA or RNA in a sample by adding primers, nucleotides, DNA polymerase and other reagents.

From Vitl Life Science Solutions 25 May 2017

Integrated CLEM and Scanning Electron Microscopes Help Gain New Insights into Blood Disorders

Blood is an essential component of the body, supplying necessary oxygen to all organs and tissues and eliminating unwanted metabolites from cells. However, in addition to transporting oxygen, blood protects the body from a variety of diseases using the immune cells and platelets present in it. These blood cells also play a role in bleeding disorders.

From Thermo Fisher Scientific Phenom-World BV 22 May 2017

Life Science White Papers

Harnessing the power of CRISPR through accurate sample prep

Using NanoBiT® Technology to Study the Dynamics of Protein Interactions in Live Cells

Normalization: An Essential Part of Bioluminescent Reporter Assay

Using Calorimetric Methods to Investigate Protein Misfolding and Aggregation

Using Dynamic Light Scattering to Screen Colloidal Aggregates of Small-Molecule Drugs

Rapid Sample Transfer Between Differing Labware Formats

Real Time Measurement of Tumor Cell Death Using IncuCyte® Immune Cell Killing Assay

Applying IncuCyte® Apoptosis Assay for the Fluorescent Detection of Caspase-3/7 Activation or Phosphatidylserine Externalization

Applications of Scanning Electron Microscope in Pharmaceutical Research Field

Using INTEGRA VIAFLO 96 System for Analysis of Drugs of Abuse

Genome Wide Comparison of N-ChIP and X-ChIP Using Solid State Chromatrap® Spin Column Technology

Using AFM to Visualize Lipid Content in Stratum

Using CLARIOstar® Microplate Reader for Real-Time Detection of Gi and Gs Signaling in Living Cells

Smart temperature control enhances PCR sample preparation

Integrated CLEM and Scanning Electron Microscopes Help Gain New Insights into Blood Disorders

High Quality Blood Agar Production Using DOSE IT and MEDIA JET

FFF for Quantification of Monoclonal Antibody Aggregates

Size-Distribution Analysis of Monodisperse Gold Nanoparticles

Temperature-Induced Antibody Decomposition

Ergonomics of Pipette Use and Handling

Leveraging the Radian ASAP in standard casework

A journey through science, software, and innovation: Insights from the Bruker software team

CellVoyant's AI-Powered Vision for the Future of Cell Therapy

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