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Life Science White Papers are in-depth articles aimed to educate and inform site visitors interested in life science research. Some of these papers are derived from sources where we have existing commercial relationships. Such articles are clearly labelled as sponsored content and are only accepted when the content is deemed to add value to the core editorial ethos of News Medical.

Standard Curve Generation for Colorimetric Assay in the Kinetic or Basic Eppendorf BioSpectrometer®

This article shows how the absorbance maxima of Ponceau-S is determined over a wavelength range of 220nm to 800nm using the Eppendorf BioSpectromenter®. The methods of analysis using this BioSpectrometer® are the detection of a maximum at 498nm while utilizing the function, Eppendorf “SpectraZoom”. Using the example of Ponceau-S, the colorimetric measurements were done by generating a standard curve. This standard programmed curve was then utilized to measure the concentration of unknown sample.

From Eppendorf 18 Feb 2016

The PROFILE NMR Technique to Characterize Monoclonal Antibodies

Monoclonal antibodies (MAbs) are an important class of drugs. They have the ability to recognize and bind to almost any molecular structure, giving them incredible potential in drug development. MAbs are primarily used in cancer, inflammatory diseases and infection, and currently represent the largest and fastest growing sector of biologic pharmaceuticals.

From Bruker BioSpin - NMR, EPR and Imaging 16 Feb 2016

Advances in 2D NMR Spectroscopy of Monoclonal Antibodies

Monoclonal antibodies (mAbs) represent one of the fastest growing classes of pharmaceuticals, and look set to be the focus of the biotherapeutics industry into the years to come.

From Bruker BioSpin - NMR, EPR and Imaging 9 Feb 2016

Using Phenom ProX Desktop Scanning Electron Microscope in Microbiology Research

Biofilms are aggregates that are formed by bacteria, which grow on surfaces. Commonly found in environments, biofilms are highly resistant to antibiotics, and as such the mechanism and regulation of biofilms are being intensively studied by scientists across the globe.

From Thermo Fisher Scientific Phenom-World BV 8 Feb 2016

Detailed Considerations for Outfitting Preclinical In Vivo Imaging Laboratory

When setting up a preclinical in vivo imaging laboratory, a number of factors have to be taken into account. These will include the use of dedicated imaging systems and the predicted and accurate workflow of studies that will have to be performed.

From Bruker BioSpin - NMR, EPR and Imaging 1 Feb 2016

Characterization of Worm-Like Micelles Based on Rheology

Exploring the characteristics of worm-like micelles (WLMs) has been the focus of numerous academic and industry-based studies. The applications of WLMs are spread across a broad range of industries, from oil recovery to personal care.

From Malvern Panalytical 21 Jan 2016

15N TROSY NMR for a Fresh View on Protein Macro-Molecules

NMR provides a range of structural and interaction insight that can complement other powerful techniques such as X-ray crystallography, mass spectrometry and electron microscopy to help researchers observe biology in real time at a true molecular level.

From Bruker BioSpin - NMR, EPR and Imaging 21 Jan 2016

Using DSC to Monitor Polyol-Induced Thermal Stability Increase in Antibodies

The steady growth of the biotechnology industry has increased the prominence of the study of protein aggregation. Monitoring and reducing the aggregation of proteins is an important aspect of protein therapeutics because aggregation is the potential cause of immunogenicity and reduced activity.

From Malvern Panalytical 21 Jan 2016

Advantages of Using DSC for Stability Screening of Engineered Proteins

Maintaining the required solubility, stability, efficacy and potency of an engineered biotherapeutic protein is critical after its expression in a recombinant system. Analysis and optimization of the characteristics of biotheraputic proteins such as monoclonal antibodies are performed during the engineering process.

From Malvern Panalytical 21 Jan 2016

Using Solid-State Standard Additions for Determining Active Ingredients in Solid Pharmaceutical Formulations

Determining an analyte in scenarios where the elimination or accurate reproduction of a matrix in a blank sample is not possible.

From Metrohm USA Inc. 18 Jan 2016

Using NIR Spectroscopy for Determining the Moisture, Fat, and Nitrogen in Human Feces

Health disorders like hepatic disorders or pancreatic insufficiency often result in malabsorption and maldigestion.

From Metrohm USA Inc. 18 Jan 2016

Simple, Rapid, and Accurate Ion Analysis of Pharmaceutical Products with Metrohm Inline Matrix Elimination

Variety of tetrazole derivatives, including antihypertensive pharmaceutical agent Irbesartan, are produced using alkali metal azides (MeN3).

From Metrohm USA Inc. 18 Jan 2016

Rapid and Non-Destructive Analysis of Solid Dosage Forms with NIRS XDS RapidContent Analyzer

High-performance liquid chromatography (HPLC) is most widely used for the analysis of dosage forms.

From Metrohm USA Inc. 18 Jan 2016

Proteomics: Top-Down or Bottom-Up?

Proteomics is playing an increasingly important role in the discovery of disease biomarkers and the identification of new therapeutic targets. Proteomics involves the separation, identification, and quantification of proteins.

From Pittcon 12 Jan 2016

Rapid and Effective Content Determination of Tablets Through Fully Automated Sample Preparation

Validating match between the active ingredient content mentioned in the packaging and actual content in a batch is a critical step in tablet manufacture.

From Metrohm USA Inc. 14 Dec 2015

Orbital-Raster-Scan Technique Helps Improve Performance of Mobile Raman Systems for Pharmaceutical Analysis

Raman spectroscopy provides a distinct spectral profile, which makes it a powerful tool.

From Metrohm USA Inc. 14 Dec 2015

Orbital-Raster-Scan Sampling Technique Enables Handheld Raman Systems to Reliably and Rapidly Determine Heterogeneous Samples

Inelastic light scattering on a sample is measured by Raman spectroscopy.

From Metrohm USA Inc. 14 Dec 2015

Life Science White Papers

Standard Curve Generation for Colorimetric Assay in the Kinetic or Basic Eppendorf BioSpectrometer®

The PROFILE NMR Technique to Characterize Monoclonal Antibodies

Advances in 2D NMR Spectroscopy of Monoclonal Antibodies

Using Phenom ProX Desktop Scanning Electron Microscope in Microbiology Research

Detailed Considerations for Outfitting Preclinical In Vivo Imaging Laboratory

Characterization of Worm-Like Micelles Based on Rheology

15N TROSY NMR for a Fresh View on Protein Macro-Molecules

Using DSC to Monitor Polyol-Induced Thermal Stability Increase in Antibodies

Advantages of Using DSC for Stability Screening of Engineered Proteins

Using Solid-State Standard Additions for Determining Active Ingredients in Solid Pharmaceutical Formulations

Using NIR Spectroscopy for Determining the Moisture, Fat, and Nitrogen in Human Feces

Simple, Rapid, and Accurate Ion Analysis of Pharmaceutical Products with Metrohm Inline Matrix Elimination

Rapid and Non-Destructive Analysis of Solid Dosage Forms with NIRS XDS RapidContent Analyzer

Proteomics: Top-Down or Bottom-Up?

Rapid and Effective Content Determination of Tablets Through Fully Automated Sample Preparation

Orbital-Raster-Scan Technique Helps Improve Performance of Mobile Raman Systems for Pharmaceutical Analysis

Orbital-Raster-Scan Sampling Technique Enables Handheld Raman Systems to Reliably and Rapidly Determine Heterogeneous Samples

Near-Infrared Spectroscopy Helps Improve Quality and Efficiency of Pharmaceutical Production Lines

Near-Infrared Assay for Rapid and Accurate Determination of Content Uniformity of Tablets

Reducing the Risk of Adverse Drug Combinations with mobilePDR

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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