Life Science White Papers

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Life Science White Papers are in-depth articles aimed to educate and inform site visitors interested in life science research. Some of these papers are derived from sources where we have existing commercial relationships. Such articles are clearly labelled as sponsored content and are only accepted when the content is deemed to add value to the core editorial ethos of News Medical.

Using Morphologi G3-ID to Characterize Protein Aggregates in Stressed Lysozyme Sample

Biotherapeutic formulations have been characterizing particles through optical microscopy for a long time. The obtained shape, size, and transparency characteristics are used to categorize particulates into distinct classes, such as sundry contaminants, silicone oil and aggregates.

From Malvern Panalytical 5 Nov 2015

Using CLARIOstar and PHERAstar FS to Monitor Ligand Binding to GPCRs in Live Cells with NanoBRET Assay

GPCRs remain the subject of intense research in the pharma and medical fields as they play a key role in transmitting cellular responses to external stimuli.

From BMG LABTECH GmbH 27 Oct 2015

Detection and Quantification of Tau Aggregates in Brain Tissue

The structures of the human brain are stabilized by tau protein and will be collapsed in the presence of abnormal tau protein, leading to plaque development.

From BMG LABTECH GmbH 27 Oct 2015

Using Mass Spectrometry to Detect Food Allergens

Food allergies are a major public health concern and are increasing worldwide. Globally, it is thought that between 220 and 250 million people suffer from a food allergy. Ninety percent of cases involve sensitivity to one of the 'Big Eight' allergens: egg, fish, milk, peanut, shellfish, soy, tree nuts, or wheat.

From Pittcon 27 Oct 2015

Ensuring Optimum Product and Operator Safety in Production of Highly Potent Drugs with Hosokawa Micron’s Containment Solutions

Hosokawa Micron offers a range of novel technologies for use in primary and secondary pharmaceutical production of active pharmaceutical ingredients and intermediates to respiratory drugs, vitamins and food supplements. The technology and skills delivered by Hosokawa Micron range from lab and pilot plant through to full manufacture, offering straight forward and practical solutions to meet complex production requirements.

From Hosokawa Micron Ltd 22 Oct 2015

Hosokawa Micron’s Integrated Batch Milling and Packing System for Processing HAPI Materials

As the demand for more effective drugs increases, so does the potency of the drugs being developed. Safeguarding and protecting both products and the operators is vital, as is taking into consideration the need to ensure maximum flexibility in the design of systems for processing highly potent active pharmaceutical ingredients (HAPI).

From Hosokawa Micron Ltd 22 Oct 2015

Major Pharmaceutical Products Manufacturer Upgrades Operation with Hosokawa Micron’s Multi-functional Dispensary Booth

Hosokawa Micron Ltd was approached by a major pharmaceutical products manufacturer wanting a customized, multi-purpose dispensary weigh booth to be developed. The aim was to increase capacity at their Centre of Excellence for tablet manufacturing and packaging, situated in the north of England.

From Hosokawa Micron Ltd 20 Oct 2015

Advances in Contaminant Testing of Dietary Supplements

In the western world, dietary supplements are a billion-dollar industry, with around half of all adults in the United States consuming such products. Many consumers like to buy products marked as herbal or “natural”, often regarding these to be better for them, or even harmless.

From Pittcon 14 Oct 2015

Faster Breath Analysis with MAX300-LG™ Breath Analyzer

The preferred gas analysis technique for most of the respiratory applications is mass spectrometry. MAX300-LG™ allows faster breath analysis that requires only a minimal sample flow.

From Extrel CMS, LLC 14 Oct 2015

How NMR Revealed p53's Hidden Abilities

As the most frequently altered gene in human cancers, p53 is possibly the most important gene in cancer biology. Indeed, the gene for p53 is damaged or missing in at least half of all cancers. Yet, despite its relevance to the field, we are still understanding how p53 functions, and recent research - with the help of nuclear magnetic resonance (NMR) spectroscopy - demonstrates how it continues to surprise us.

From Bruker BioSpin - NMR, EPR and Imaging 2 Oct 2015

Measuring Silver Distribution in Wound Dressings

The occurrence of bacterial infection occurring with certain kinds of wounds can be minimized by using wound dressings containing silver.

From Thermo Fisher Scientific – X-Ray Photoelectron Spectroscopy (XPS) 24 Sep 2015

Surface Characterization of Disposable Laboratory Gloves

Disposable elastic gloves are widely used in scientific laboratories and in many industries for the handling of critical surfaces.

From Thermo Fisher Scientific – X-Ray Photoelectron Spectroscopy (XPS) 24 Sep 2015

Characterization of Protein Stability Using Differential Scanning Calorimetry

One of the major advantages of differential scanning calorimetry (DSC) is that it depends on heat measurements, which make characterization of native biomolecules possible.

From Malvern Panalytical 14 Sep 2015

Characterizing Exosomes and Microvesicles with Nanoparticle Tracking Analysis

To arrive at the particle size distribution of samples in a liquid suspension, nanoparticle tracking analysis (NTA) uses the characteristics of both Brownian motion and light scattering. A laser beam is transmitted via a sample chamber and the suspended particles in the beam path disperse light in such a way that is possible to observe clearly using a camera-mounted 20x magnification microscope.

From Malvern Panalytical 14 Sep 2015

Chromatrap® - Rapid, Consistent, High-Throughput ChIP-seq Assay for Protein-DNA Analysis

One of the major tasks in present-day biology is to map the chromosomal positions of nucleosomes, TFs, chromatin remodeling enzymes, histone modifications, polymerases and chaperones. Genome-wide profiling of histone alterations and DNA-binding proteins is performed using a method called chromatin immunoprecipitation followed by sequencing or ChIP-seq.

From Chromatrap® - Porvair Sciences Ltd 9 Sep 2015

Top Tips for Handheld Pipetting

Best pipetting practices are key to producing optimal results. Pipetting errors occur when common technique mistakes are made that lead to discrepancies.

From INTEGRA Biosciences 3 Sep 2015

Using Dynamic Light Scattering Technique to Measure the Size of Submicron Liposomes

This article looks at the use of dynamic light scattering technique to measure the size of submicron liposomes.

From Entegris 27 Aug 2015

Samsung Medical Center Installs ABB’s PCS100 AVCs to Protect Cancer Treatment Machines from Voltage Fluctuations

Korean-based company, Samsung Medical Center (SMC) has installed four PCS100 active voltage conditioners (AVCs) at its facility. The installation process was successfully carried out by the Power Electronics team at ABB.

From ABB Limited 17 Aug 2015

Using Taylor Dispersion Analysis for Evaluating the Self-Association Behavior of Insulin with Concentration

Taylor dispersion analysis, also referred to as TDA, is an orthogonal method used for stability and sizing analyses of biomolecules in solution. Research has shown that hydrodynamic radius (Rh) measurements obtained from TDA on monoclonal antibodies (mAbs) and other mono-disperse, unstressed protein-based systems are analogous to data acquired using dynamic light scattering (DLS), a well-known, complementary method.

From Malvern Panalytical 30 Jul 2015

Relative Viscosity Screening of Monoclonal Antibody Formulations at Low Concentrations and Low Viscosities

The biopharmaceutical industry faces a continuous pressure to deliver innovative treatments in a safe and appropriate manner, including the rapidly growing area of therapeutic antibodies.