Life Science White Papers

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Life Science White Papers are in-depth articles aimed to educate and inform site visitors interested in life science research. Some of these papers are derived from sources where we have existing commercial relationships. Such articles are clearly labelled as sponsored content and are only accepted when the content is deemed to add value to the core editorial ethos of News Medical.

Rapid and Non-Destructive Analysis of Solid Dosage Forms with NIRS XDS RapidContent Analyzer

Rapid and Non-Destructive Analysis of Solid Dosage Forms with NIRS XDS RapidContent Analyzer

High-performance liquid chromatography (HPLC) is most widely used for the analysis of dosage forms.

From Metrohm USA Inc. 18 Jan 2016

Proteomics: Top-Down or Bottom-Up?

Proteomics: Top-Down or Bottom-Up?

Proteomics is playing an increasingly important role in the discovery of disease biomarkers and the identification of new therapeutic targets. Proteomics involves the separation, identification, and quantification of proteins.

From Pittcon 12 Jan 2016

Rapid and Effective Content Determination of Tablets Through Fully Automated Sample Preparation

Rapid and Effective Content Determination of Tablets Through Fully Automated Sample Preparation

Validating match between the active ingredient content mentioned in the packaging and actual content in a batch is a critical step in tablet manufacture.

From Metrohm USA Inc. 14 Dec 2015

Orbital-Raster-Scan Technique Helps Improve Performance of Mobile Raman Systems for Pharmaceutical Analysis

Orbital-Raster-Scan Technique Helps Improve Performance of Mobile Raman Systems for Pharmaceutical Analysis

Raman spectroscopy provides a distinct spectral profile, which makes it a powerful tool.

From Metrohm USA Inc. 14 Dec 2015

Orbital-Raster-Scan Sampling Technique Enables Handheld Raman Systems to Reliably and Rapidly Determine Heterogeneous Samples

Orbital-Raster-Scan Sampling Technique Enables Handheld Raman Systems to Reliably and Rapidly Determine Heterogeneous Samples

Inelastic light scattering on a sample is measured by Raman spectroscopy.

From Metrohm USA Inc. 14 Dec 2015

Near-Infrared Spectroscopy Helps Improve Quality and Efficiency of Pharmaceutical Production Lines

Near-Infrared Spectroscopy Helps Improve Quality and Efficiency of Pharmaceutical Production Lines

Cost-effective, high-accuracy drug analysis is essential for regular QC purposes and for determination of counterfeit medicines that are potentially harmful.

From Metrohm USA Inc. 14 Dec 2015

Near-Infrared Assay for Rapid and Accurate Determination of Content Uniformity of Tablets

Near-Infrared Assay for Rapid and Accurate Determination of Content Uniformity of Tablets

Substantial interest has been shown towards testing of solid dosage samples more often than the recommendation by the USP monograph on content uniformity.

From Metrohm USA Inc. 14 Dec 2015

Reducing the Risk of Adverse Drug Combinations with mobilePDR

Reducing the Risk of Adverse Drug Combinations with mobilePDR

The incidence of drug interactions and adverse effects continues to increase due to the rise of multi-drug administration and the aging population in developed nations.

From Physicians' Desk Reference (PDR) 10 Dec 2015

Fully Automated Titrimetric Determination of Active-Substance Content Using 815 Robotic Titration Soliprep

Fully Automated Titrimetric Determination of Active-Substance Content Using 815 Robotic Titration Soliprep

Obtaining reliable analysis results is very critical in the pharmaceutical industry.

From Metrohm USA Inc. 10 Dec 2015

Fully Automated Fluoride Determination in Blood Samples

Fully Automated Fluoride Determination in Blood Samples

Biological samples used for alcohol analysis are usually preserved using sodium fluoride.

From Metrohm USA Inc. 10 Dec 2015

Dissolution Testing by NIRS for Fast, Accurate, Non-Destructive Assessment of Tablets

Dissolution Testing by NIRS for Fast, Accurate, Non-Destructive Assessment of Tablets

Manufacture of solid dosage forms, the rate active pharma ingredient is dissolved simulating the digestive tract fluids is determined with dissolution testing.

From Metrohm USA Inc. 10 Dec 2015

Determining Permeability of Intestine Lactulose and Mannitol by Ion Chromatography with Pulsed Amperometric Detection

Determining Permeability of Intestine Lactulose and Mannitol by Ion Chromatography with Pulsed Amperometric Detection

The use of ion chromatography with amperometric detection for simple and reliable determination of lactulose and mannitol in urine is described in this article.

From Metrohm USA Inc. 10 Dec 2015

Stabilizing Lipid Bilayer Membranes

Stabilizing Lipid Bilayer Membranes

Ion channels are essential to key cellular processes including signal transduction, osmoregulation and maintenance of the membrane potential. They are therefore the targets of many clinically used drugs.

From Pittcon 9 Dec 2015

Accurate Detection of API Release from Sustained-Release Tablets Using Near-Infrared Spectroscopy

Accurate Detection of API Release from Sustained-Release Tablets Using Near-Infrared Spectroscopy

Numerous therapeutic advantages are offered by sustained-release drugs, which release active pharmaceutical ingredients (APIs) in a gradual manner.

From Metrohm USA Inc. 8 Dec 2015

Stimulated Raman Scattering (SRS) Microscopy and Cancer Detection

Stimulated Raman Scattering (SRS) Microscopy and Cancer Detection

The ability to distinguish cancer cells from healthy cells during surgery is essential for preventing the removal of healthy tissue and ensuring no tumor remnants are left behind.

From Pittcon 24 Nov 2015

Using the Eppendorf BioSpectrometer® Fluorescence for Evaluating RNA Quantification Kits

Using the Eppendorf BioSpectrometer® Fluorescence for Evaluating RNA Quantification Kits

UV-VIS spectrometers are commonly used for determining the concentration of nucleic acids through light absorption measurements. The absorbance measurements are carried out at 260nm, and a conversion factor specific to the sample is used for calculating the concentration.

From Eppendorf 20 Nov 2015

Highly Precise Photometric Measurements of Nucleic Acids or Proteins using Eppendorf µCuvette™ G1.0

Highly Precise Photometric Measurements of Nucleic Acids or Proteins using Eppendorf µCuvette™ G1.0

A necessary step in the preparation of biomolecules for downstream applications is determining their concentration by photometric methods, once the nucleic acids or proteins are isolated.

From Eppendorf 20 Nov 2015

Using Eppendorf BioSpectrometer® Fluorescence for Nucleic Acid Concentration Measurements

Using Eppendorf BioSpectrometer® Fluorescence for Nucleic Acid Concentration Measurements

Quantification of nucleic acid concentrations is often performed by measuring light absorption in UV-VIS spectrometers. There are a few challenges faced in this measurement method.

From Eppendorf 19 Nov 2015

Simplifying Drug Evaluation with the mobilePDR App

Simplifying Drug Evaluation with the mobilePDR App

Making the best treatment decision for each patient can be a daunting task for healthcare professionals. As of 2013, there were 1453 molecular entities approved by the FDA for use in the United States, in addition to the new medications introduced each year and the extensive range of over-the-counter drugs.

From Physicians' Desk Reference (PDR) 19 Nov 2015

Understanding Alzheimer’s Disease Through Genomics and Proteomics

Understanding Alzheimer’s Disease Through Genomics and Proteomics

Alzheimer’s disease is a progressive neurodegenerative condition that causes dementia. In this disease, dementia symptoms such as memory loss and difficulties with language, problem-solving and reasoning gradually worsen until they eventually start to interfere with everyday life and basic tasks such as eating and drinking.

From Pittcon 11 Nov 2015

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