Life Science White Papers

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Life Science White Papers are in-depth articles aimed to educate and inform site visitors interested in life science research. Some of these papers are derived from sources where we have existing commercial relationships. Such articles are clearly labelled as sponsored content and are only accepted when the content is deemed to add value to the core editorial ethos of News Medical.

Using FTIR Spectroscopy to Determine Protein Secondary Structure

Proteins are the basic building blocks of life. They play a critical role in cell function and structure and are involved in transport, communication and metabolism in the body.

From Specac Ltd 20 Jun 2016

Metrohm’s Fully Automated Method for Determination of Water Content in Tablets

The release rate and the shelf life of active substances present in tablets are influenced by their water content.

From Metrohm USA Inc. 16 Jun 2016

Ion Chromatography – A Universal Technique with Many Applications in the Pharmaceutical Industry

Maintaining high levels of drug quality and safety is priority for the pharmaceutical industry.

From Metrohm USA Inc. 16 Jun 2016

Advantages and Disadvantages of Native and Cross-Linked Chromatin Immunoprecipitation

Two major options are available that can be used for preparing chromatin during the chromatin immunoprecipitation (ChIP) process. These include using a chemical agent like formaldehyde (X-ChIP) to crosslink the chromatin, or using native ChIP (N-ChIP) for non-cross linking the chromatin.

From Chromatrap® - Porvair Sciences Ltd 16 Jun 2016

Triple Detection Size Exclusion Chromatography (SEC-TD) Analysis of Protein-Protein Interactions

The biological function of proteins relies on their ability to form structured, ordered complexes such as homo-oligomers or hetero-oligomers. Attributes such as stability, activity, and localization can be controlled by these complexes.

From Malvern Panalytical 15 Jun 2016

Particle Analysis of Small Sample Volumes Using Hydro SV

Most of the time, only minimal volumes of the sample are available for particle size analysis. Typically, in catalysis and pharmaceutical industries, particle size analysis needs to be conducted at initial stages of product development, when the available quantity of the material to be analyzed is only a few milligrams. In such cases, reliable measurements on minute sample volumes are required, and the sample needs to be retrieved for further analysis.

From Malvern Panalytical 15 Jun 2016

Investigation of MRT Contrast Media Containing Gadolinium by Means of IC-ICP/MS Analysis

Healthy and diseased tissues can be distinguished with highly detailed image of the organ provided by non-invasive diagnostics that make use of contrast agents.

From Metrohm USA Inc. 8 Jun 2016

Content Determination of Amino Acids Using Ion Chromatography

There are currently 22 amino acids determined as protein building blocks.

From Metrohm USA Inc. 8 Jun 2016

Applications of Nanoparticle Tracking Analysis in Nanomedicine

Nanoparticles are increasingly being used in a wide range of sectors. This article evaluates particular mechanisms through which nanoparticles are uniquely developed and formulated. It also discusses the important role of nanoparticle tracking analysis (NTA) in the field of nanomedicine.

From Malvern Panalytical 6 Jun 2016

Applications of Nanoparticle Tracking Analysis in Drug and Gene Delivery

Nanoparticle tracking analysis (NTA) is a unique method that provides fast and multi-parameter information about nanoparticles. With the help of this technique, users can acquire number frequency distributions of particle sizes in polydisperse nanoparticulate systems.

From Malvern Panalytical 6 Jun 2016

LUNA-II™: An Automated Cell Counter with High Accuracy and Low Variability

In the field of biomedical research, accurate counting of cells is extremely important for ensuring both inter- and intra-lab reproducibility. Inaccurate cell counts have a negative impact not only on the reproducibility, but also on the potency and/or efficacy of cell therapy, disease diagnosis, the growth rate of regenerated tissues and various bioassays.

From Logos Biosystems 3 Jun 2016

Using X-CLARITY™ Mounting Solution for Efficient RI Matching of Cleared and Immunolabeled Tissues

The X-CLARITY™ Tissue Clearing System is a cutting edge advancement in the field of biomedical research, transforming biological tissue into a state transparent to light. This system removes lipids electrophoretically from the tissue-hydrogel hybrids. Lipids are fat molecules that are the main component of light scattering in biological tissues.

From Logos Biosystems 3 Jun 2016

Evaluation of Mixing Performance of Vitl Co-Mix Laboratory Mixer with High Viscosity Solutions

An orbital mixer’s efficiency is significantly affected by the viscosity of a solution. Commonly used non-aqueous mixing solvents for dyes, vaccines, and drugs are viscous liquids such as glycerol and polyethylene-glycol (PEG). These liquids are also used in protein solutions as stabilizing agents. The performance of a Vitl Co-Mix in mixing solutions containing a higher proportion of glycerol in various tubes and microplates was evaluated in this study.

From Vitl Life Science Solutions 29 Apr 2016

Vitl’s Bespoke Lab Equipment Solutions Optimize Customer Methods

Since Vitl was established as an engineering company, it can produce custom-made lab products and software that are optimized for users’ methods. This article provides a few examples of how Vitl has customized its lab products in the past.

From Vitl Life Science Solutions 29 Apr 2016

Medway School of Pharmacy Team Reproducibly Produces and Tests Nanomaterials Using Vitl's Mixers

Nanoparticles are tiny delivery vehicles that can travel to regions where no drugs have gone before and provide the treatment at the right dose and time, with little to no side-effects. They have long been considered as having the potential to transform the future of medicine. In this article, Dr Vladimir Gubala, lecturer in Chemistry and Drug Delivery at the Medway School of Pharmacy, describes the challenges and benefits of using Vitl's Co-Mix.

From Vitl Life Science Solutions 26 Apr 2016

History and Product Range of Vitl Life Science Solutions

Vitl is a brand within the Integrated Technologies Ltd (ITL) group, which is a global product development and manufacturing company. The group has more than four decades of experience in instrument design and manufacturing projects, targeting medical devices, in vitro diagnostics (IVD), and laboratory equipment. The dedicated development team consists of ex-ITL engineers who have developed all Vitl products using this experience. This article discusses the team’s main milestones.

From Vitl Life Science Solutions 26 Apr 2016

Quantitative Measurement of Active Neutrophil Elastase Levels Using ProteaseTag™ Active NE Immunoassay

Lung function may be affected due to cycles of prolonged inflammation as well as chronic infection of the airways that lead to respiratory diseases.

From BMG LABTECH GmbH 18 Apr 2016

Flexible Technology Accelerates Diagnosis of Prostate Cancer

Prostate cancer is a common malignant disease seen in men, which accounts for almost one-third every year of all the new diagnoses made for cancer.

From Huron Digital Pathology 23 Mar 2016

Intracytoplasmic Sperm Injection Using Eppendorf Transferman® 4m Micromanipulator

Studies on assisted fertilization via micromanipulation techniques have gradually evolved from 1988 to the present day. The technique of intracytoplasmic sperm injection or ICSI (Figure 1) is a great benefit in providing treatment for infertile couples, especially those patients with male factor.

From Eppendorf 21 Mar 2016

Eppendorf TransferMan® 4r – All-Encompassing Manipulator for Genetic Engineering Techniques

The modification of laboratory animal genomes is carried out by micromanipulation of embryos or oocytes. The usual techniques of micromanipulation are: transcription activator-like effector nuclease (TALEN) into the cytoplasm into a pronucleus of early zygotes; or microinjection of nucleic acid constructs like larger bacterial artificial chromosomes (BAC), simple transgenes, and zinc finger (ZFN).