Life Science White Papers

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Life Science White Papers are in-depth articles aimed to educate and inform site visitors interested in life science research. Some of these papers are derived from sources where we have existing commercial relationships. Such articles are clearly labelled as sponsored content and are only accepted when the content is deemed to add value to the core editorial ethos of News Medical.

An Overview of Proton Detection in Biological Samples Under Ultra-Fast Magic Angle Spinning

Attributes like natural abundance of over 99.9% and a high gyromagnetic ratio help in the characterization of protons. Thanks to these attributes, a greater detection sensitivity than those of 15N or 13C is obtained which makes 1H-detected NMR spectroscopy extremely attractive, and not only for solution NMR.[1-6]

From Bruker BioSpin - NMR, EPR and Imaging 31 Aug 2017

Using TD-NMR Analysis for Fast and Reliable Quality Control for Toothpaste Production

Many ingredients are added to mouthwash and toothpaste to improve both health benefits and quality. Fluorine is one such ingredient that is added to these items to strengthen tooth enamel and thus prevent cavities. This chemical element is typically added in the amounts of 1000 to 1500 ppm.

From Bruker BioSpin - NMR, EPR and Imaging 31 Aug 2017

Analysis of Gadolinium-Based MRI Contrast Agents Using IC-ICP/MS Technique

Gadolinium contrast agents, which are mainly administered via intravenous injection, exhibit excellent in vitro and in vivo stability.

From Metrohm USA Inc. 31 Aug 2017

Electron Paramagnetic Resonance Aids Cancer Drug Development

Chromosome instability is a key hallmark of cancers, increasing mutation rates and helping tumor cells evade destruction by the immune system as well as treatment by medical interventions. Hypoxia contributes to this instability, causing replication stress and a subsequent loss of the cellular machinery required to deal with DNA damage.

From Bruker BioSpin - NMR, EPR and Imaging 30 Aug 2017

Nuclear Magnetic Resonance Helps Researchers Improve Drug Delivery

Modern medicine has evolved rapidly over the past century, and the development of safe and effective drugs has been a key factor in reducing death and disability from diseases which were once a death sentence. Advances in vaccination led to the complete elimination of small pox by 1990, and as of 2016, polio cases have been reduced by 99% worldwide as well.1,2 Pharmacological agents, such as statins, chemotherapeutics, and anti-retroviral therapies have made incredible progress in treating heart disease, cancer, and HIV/AIDS.

From Bruker BioSpin - NMR, EPR and Imaging 24 Aug 2017

GoTaq® MDx Hot Start Polymerase: A General Purpose Reagent for Molecular Diagnostic Assays

Many PCR-based molecular diagnostic tests utilize a hot-start thermostable DNA polymerase.

From Promega Corporation 21 Aug 2017

Using Online NMR Reaction Monitoring to Understand Mechanisms and Kinetics of Chemical Reactions

Nuclear magnetic resonance (NMR) is a structurally rich and non-intrusive technique that is quantitative by nature. These inherent characteristics make NMR extremely robust for identifying and characterizing reaction intermediates, thus allowing a better understanding about the kinetics of chemical reactions and reaction mechanisms.

From Bruker BioSpin - NMR, EPR and Imaging 18 Aug 2017

Adopting a Best-in-Class Strategy for Digital Pathology

Anyone who is tasked with implementing a digital pathology workflow faces a dilemma - do you buy from a single vendor or take a best-in-class approach?

From Huron Digital Pathology 16 Aug 2017

Could Fragment-Based Screening Using NMR Tackle Antibiotic Resistance?

With antibiotic resistance continuing to gain pace globally, there is increasing need for fresh approaches in drug discovery to avoid a future in which deaths from previously preventable infections are common.

From Bruker BioSpin - NMR, EPR and Imaging 15 Aug 2017

Solid Fat Content Determination by Time Domain (TD) NMR Analysis

Determining solid fat content (SFC) is important in the processing and development of food products. It is essential to characterize and control raw materials like fat compositions or blends in accordance with their melting profiles.

From Bruker BioSpin - NMR, EPR and Imaging 11 Aug 2017

Nuclear Magnetic Resonance Reveals New Drug Compounds

In 1971 President Nixon declared a “war on cancer”, when signing the National Cancer Act into US law.1 Since then, researchers, funding agencies, outreach groups, and clinicians have made great progress towards eradicating this devastating set of diseases.

From Bruker BioSpin - NMR, EPR and Imaging 10 Aug 2017

Using EPA 300 Method for Determination of Anions in Tap Water

Maximum Contamination Levels in drinking water are established by EPA through the Safe Drinking Water Act. EPA controls industry discharge MCL.

From Metrohm USA Inc. 9 Aug 2017

Trends and Developments of Ion Chromatography in Pharmaceutical Analysis

As a highly flexible technique, ion chromatography (IC) has many practical applications in the pharmaceutical field.

From Metrohm USA Inc. 9 Aug 2017

On-Field Determination of Arsenic, Mercury, and Copper in Ground Water

Mercury and arsenic are examples of heavy metals that can be found in ground water across many parts of the world.

From Metrohm USA Inc. 9 Aug 2017

Determination of Glyphosate and AMPA in Drinking Water Using Ion Chromatography with Pulsed Amperometric Detection

Glyphosate is a broad-spectrum herbicide that is widely used in agriculture across the globe.

From Metrohm USA Inc. 9 Aug 2017

Advantages of Using a Peristaltic Pump to Transfer Liquids

Ensuring proper liquid transfer with high precision and free of contamination is a key challenge in using pumps for liquid transfer.

From INTEGRA Biosciences 8 Aug 2017

High Resolution BOLD Functional MRI Provides New Insights on Rat Brain

Four-element array coils and high field small animal MR scanners can be used to obtain functional MRI, also known as fMRI, at a high spatial resolution of 75 x 75 x 1000 μm3. The activation area contains fine and detailed substructures, which can be identified at unparalleled in vivo resolution, thereby widening the scope and understanding of the origin and biophysical principles of blood-oxygenation-level dependent (BOLD) to get a better insight into structure and organization of the brain.

From Bruker BioSpin - NMR, EPR and Imaging 4 Aug 2017