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Imlunestrant offers new hope for ER-positive HER2-negative breast cancer

Imlunestrant, an investigational next-generation selective estrogen receptor degrader (SERD), improved progression-free survival in patients with endocrine therapy-pretreated, ER-positive, HER2-negative advanced breast cancer - as monotherapy in patients with ESR1 mutations and as combination therapy with abemaciclib (Verzenio) in all patients, regardless of ESR1 mutation status - according to results from the phase III EMBER-3 clinical trial presented at the San Antonio Breast Cancer Symposium (SABCS), held December 10-13, 2024.

11 Dec 2024

Risk-reducing surgeries provide benefits for young BRCA-mutation carriers

Patients with germline BRCA mutations who were diagnosed with breast cancer at or before age 40 and who underwent a bilateral risk-reducing mastectomy (RRM) and/or a risk-reducing salpingo-oophorectomy (RRSO) had lower rates of recurrence, secondary breast and/or ovarian malignancies, and death than those who did not undergo these surgeries, according to results presented at the San Antonio Breast Cancer Symposium (SABCS), held December 10-13, 2024.

11 Dec 2024

Weight gain after 35 linked to increased breast cancer risk

The body mass index (BMI) has long been used to measure body fat, but its influence on breast cancer risk is more complex than previously thought.

11 Dec 2024

Olaparib provides survival benefits for high-risk BRCA-positive breast cancer patients

Patients with high-risk, BRCA-positive breast cancer who received olaparib (Lynparza) after standard treatment continued to have better survival outcomes than those who received placebo after a median follow-up of 6.1 years, according to the latest results from the phase III OlympiA clinical trial presented at the San Antonio Breast Cancer Symposium (SABCS), held December 10-13, 2024.

11 Dec 2024

FunMap reveals new insights into cancer-associated genes and proteins

Large-scale protein and gene profiling have massively expanded the landscape of cancer-associated proteins and gene mutations, but it has been difficult to discern whether they play an active role in the disease or are innocent bystanders.

11 Dec 2024

Cleveland Clinic study reveals kidney microbiome's role in renal health

Cleveland Clinic researchers have found definitive proof of a kidney microbiome that influences renal health and kidney stone formation, demonstrating that the urinary tract is not sterile and low levels of bacteria are normal.

11 Dec 2024

TCR sequencing sheds light on tumor immune interactions in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) stands as the dominant form of liver cancer, ranking as the fourth leading cause of cancer-related deaths globally.

11 Dec 2024

Wiley expands its KnowItAll solutions with new tools for LC-MS analysis, enterprise data management, and additional spectral advances

The latest KnowItAll software accelerates spectral analysis, featuring automated LC-MS tools and extensive spectral libraries to optimize research workflows.

From John Wiley and Sons - Scientific Publishers 11 Dec 2024

Study reveals ableism as a barrier to mental health care for disabled individuals

People with disabilities (PWD) make up 25% of the U.S. population. They face elevated mental health concerns and are more likely to utilize mental health services compared to non-disabled individuals.

11 Dec 2024

Prostate cancer vaccines: Progress, challenges, and future directions

Prostate cancer vaccines, including dendritic and peptide types, offer hope for improved treatments, but face hurdles in clinical effectiveness and validation.

11 Dec 2024

High-dose chemotherapy followed by autologous stem cell transplant ineffective for patients with mantle cell lymphoma

Late-breaking research reveals there is no benefit from high-dose chemotherapy followed by autologous stem cell transplant (ASCT) for patients with mantle cell lymphoma (MCL) in remission following their initial treatment.

11 Dec 2024

New research explores hidden health risks of hereditary hemochromatosis

A study links undetected diabetes in hemochromatosis patients to increased mortality, highlighting the need for early detection and revised clinical guidelines.

11 Dec 2024

Study links metal exposure to overweight and obesity in children

Researchers from the Granada Biosanitary Research Institute (ibs.GRANADA) and the University od Granada have revealed positive and negative associations between exposure to a combination of different metals and overweight and obesity in children.

11 Dec 2024

New tool helps surgeons plan heart valve replacements with precision

Scientists at Queen Mary University of London and Barts Health have developed an innovative tool that simulates blood flow in the aorta, helping heart surgeons plan surgeries more precisely.

11 Dec 2024

Study highlights disparities in stroke costs across healthcare services in Latin America

This study assesses acute ischemic stroke costs in Latin America, revealing treatment variations and economic challenges that impact healthcare accessibility.

11 Dec 2024

Early exposure to parental smoking linked to higher MS risk

Cutting early life exposure to parental smoking may lower the risk of developing MS (multiple sclerosis) in those who are genetically predisposed to the disease, finds research published online in the Journal of Neurology Neurosurgery & Psychiatry.

11 Dec 2024

Quality breakfast reduces the risk of cardiovascular disease

Having a quality breakfast that provides the right amount of energy to face the day, around a quarter of daily intake, reduces the risk of cardiovascular disease.

11 Dec 2024

Study reveals gut microbiome’s person-specific role in glycemic sensitivity

Research reveals how individual gut microbiota responses to high-carbohydrate diets influence glycemic sensitivity, paving the way for personalized nutrition.

11 Dec 2024

Bedfont® Scientific Limited Secures a Double Win at the Kent Business Awards

Crowned Medium Business of the Year 2024 and Best of Kent, Bedfont® showcases its leadership in breath analysis technology and sustainable business practices.

From Bedfont® Scientific Ltd 11 Dec 2024

Higher cardiorespiratory fitness improves cognitive function in older age

Higher cardiorespiratory fitness in older age is linked to the preservation of several core aspects of cognitive ability that are vulnerable to age-related decline, finds research published online in the British Journal of Sports Medicine.

11 Dec 2024