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Impaired lipid transport protein locks stressed cells into cellular limbo

When cells experience enough chronic stress, they can stop dividing permanently. In this state of cellular limbo, known as replicative senescence, cells remain alive but no longer proliferate.

31 Mar 2026

New optogenetic method precisely controls marmoset brain communication pathways

Understanding how the brain works requires more than studying single regions in isolation. The cerebral cortex depends on long-distance connections that link specialized areas into coordinated networks.

31 Mar 2026

Gene signature maps cholangiocarcinoma subtypes for precision treatment

Intrahepatic cholangiocarcinoma (iCCA), the second most common primary liver cancer after hepatocellular carcinoma, remains one of the most challenging malignancies to treat due to its highly concealed and heterogeneous nature.

31 Mar 2026

Genomic study advances prioritization of variants in cancer diagnostics

Hiroshima University researchers have developed a practical framework to identify candidate pathogenic variants hidden among the large number of variants of uncertain significance (VUS) detected in comprehensive genomic profiling (CGP) of cancers.

31 Mar 2026

Plant-focused diets may decelerate epigenetic aging processes

A new research paper was published in Volume 18 of Aging-US on March 20, 2026, titled "Plant-based dietary patterns are associated with slower epigenetic aging."

31 Mar 2026

Unhealthy air exposure expected to rise sharply in coming decades

New modeling shows almost one in three Americans will routinely breathe air considered unhealthy for sensitive people by the year 2100 due to climate change, a sevenfold increase compared to the turn of the century.

31 Mar 2026

Antibiotic resistance genes found in both diseased and healthy lungs

The researchers examined patients with COPD, asthma, pulmonary fibrosis (IPF), and sarcoidosis, and compared them with healthy individuals.

31 Mar 2026

Restoring tissue stiffness may reduce inflammation in gum disease

Periodontitis is a serious chronic inflammatory form of gum disease that affects millions worldwide. It can lead to tooth loss and the destruction of supporting bone.

31 Mar 2026

Gut-derived metabolites regulate immune cells in complex ways

Published on March 23, 2026, in Volume 2, article number 18 of the journal Immunity & Inflammation, the review begins by systematically outlining the sources and synthetic pathways of immune-relevant microbial metabolites, including bile acids, short-chain fatty acids, amino acid derivatives, vitamins, trimethylamine/trimethylamine N-oxide, and odd-chain fatty acids.

31 Mar 2026

Novel MRI technique reveals sleep-driven brain cleansing mechanisms

Sleep helps the brain to cleanse itself – and now this process can be measured in humans entirely non-invasively.

31 Mar 2026

Strategic Partnerships at PHARMAP 2026 – Big Pharma’s Shift Toward CDMOs and CMOs

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31 Mar 2026

Mirror image proteins offer new way to disable Alzheimer's disease

Understanding how proteins interact with their own mirror images enabled a Kobe University research team to design a small mirror protein that disables a causal factor of Alzheimer's disease, amyloid-beta.

31 Mar 2026

How swapping unhealthy foods can significantly reduce your heart risk

More than half of adults and about 60% of children in the U.S. have unhealthy diets, which can contribute to higher rates of health factors such as high blood pressure and obesity, and lead directly to poor health outcomes including deaths from cardiovascular disease and other chronic conditions, according to the American Heart Association.

31 Mar 2026

Excessive RNA editing enzyme alters brain circuit formation in Down syndrome

A collaborative research study co-led by scientists at the Icahn School of Medicine at Mount Sinai and the Liber Institute for Brain Development has for the first time identified a biological process that may help explain how the brain develops differently in people with Down syndrome.

31 Mar 2026

Scientists use living muscle to reanimate paralyzed organs

What if a technology could reanimate parts of the body that have lost their connection to the brain - like a bladder that can no longer empty due to a spinal cord injury, or intestines that can't push food forward due to Crohn's disease? What if this technology could also send sensations such as hunger or touch back to the brain?

31 Mar 2026

Lifestyle care in primary clinics allows for safe diabetes deprescribing

A new research study provides real-world evidence that deprescribing glucose‑lowering medications is both feasible and safe when patients with type 2 diabetes receive lifestyle‑informed care in primary care settings.

31 Mar 2026

Semarion secures $3.8 million to scale next-generation cell assay technology and accelerate pharma adoption

Semarion, a University of Cambridge spin-out company from the Cavendish Laboratory combining materials engineering and cell biology to tackle unmet drug screening needs, today announced it has raised $3.8 million USD (£2.9 million GBP).

From Semarion 31 Mar 2026

Broken String Biosciences rebrands to reflect strategic evolution as demand grows for unbiased genome-wide off-target analysis

Broken String Biosciences, a biotechnology company enabling gene editing teams to accelerate development of safer, more effective genetic medicines, today introduced new branding and comprehensive website as part of its strategic repositioning.

From Broken String Biosciences 31 Mar 2026

Trump’s hunt for undocumented Medicaid enrollees yields few violators

Last August, as part of the federal government's crackdown on people in the country illegally, the Trump administration sent states the names of hundreds of thousands of Medicaid enrollees with orders to determine whether they were ineligible based on immigration status.

31 Mar 2026

States pay Deloitte, others millions to comply with Trump law to cut Medicaid rolls

States are paying contractors such as Deloitte, Accenture, and Optum millions of dollars to help them comply with the One Big Beautiful Bill Act — a law that will strip safety-net health and food benefits from millions.

31 Mar 2026