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Breakthrough research offers first targeted treatment option for NRAS-mutant melanoma

New research from Moffitt Cancer Center shows that RAS(ON) multi-selective inhibition can directly block tumor growth and activate the immune system, offering the first targeted approach for patients with NRAS-mutant melanoma, an aggressive form of skin cancer with limited treatment options beyond immune checkpoint inhibitors.

4 Nov 2025

UCLA experts call for individualized heart monitoring in breast cancer survivors

As breast cancer survival rates continue to climb - 4.3 million women in the U.S. are currently living with a history of the disease and in the next 10 years that number is expected to rise by another million - heart health has become an increasingly important part of survivorship care.

4 Nov 2025

Study finds high intake of ultra-processed foods tied to reduced DNA methylation

Women who consumed more ultra-processed foods (UPFs) showed distinct DNA methylation patterns, mostly reduced across key gene regions. These exploratory findings suggest that high UPF intake may influence gene regulation through epigenetic mechanisms.

4 Nov 2025

MRI-based computer models offer early insight into bone healing

Healing a broken bone can take months, and knowing whether recovery is on track often takes just as long.

4 Nov 2025

USC researchers map genetic architecture of the human corpus callosum

For the first time, a research team led by the Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) at the Keck School of Medicine of USC has mapped the genetic architecture of a crucial part of the human brain known as the corpus callosum-the thick band of nerve fibers that connects the brain's left and right hemispheres.

4 Nov 2025

New initiative aims to accelerate aortic stenosis diagnosis and treatment

People living with aortic stenosis (AS) could gain earlier access to innovative care and treatment thanks to a new effort from the American Heart Association designed to boost clinical trial participation and speed diagnosis of this common but underdiagnosed heart valve condition.

4 Nov 2025

UQ researchers capture first high-resolution images of the yellow fever virus

University of Queensland researchers have captured the first high-resolution images of the yellow fever virus (YFV), a potentially deadly viral disease transmitted by mosquitoes that affects the liver.

4 Nov 2025

Children face greater heart and inflammatory risks after COVID-19 infection than vaccination

The study is the largest of its kind in this population, and is published in The Lancet Child and Adolescent Health.

4 Nov 2025

Survival patterns differ across types of early-onset dementia

The survival rates of people with early onset dementia-diagnosed before the age of 65-vary considerably by clinical type, but sex, age, family history and co-existing conditions aren't specific risk factors, finds research published online in the Journal of Neurology Neurosurgery & Psychiatry.

4 Nov 2025

Swapping meat for plant-based options cuts fat but lowers protein, study finds

Replacing meat with plant-based or mycoprotein alternatives in UK diets lowers saturated fat and boosts fiber but reduces protein intake, especially for teens and older adults. The overall saturated fat reduction is too small to meaningfully affect cholesterol levels, researchers report in npj Science of Food.

4 Nov 2025

Do GLP-1 drugs cause cancer? New review says no, may even protect

A comprehensive review in The Journal of Clinical Investigation finds no overall link between GLP-1 receptor agonists and increased cancer risk, countering early safety concerns. Instead, evidence suggests possible protective effects for certain cancers, supported by metabolic and immune-modulating mechanisms.

4 Nov 2025

GLP-1 drugs calm inflammation beyond diabetes and weight loss

This Journal of Clinical Investigation review describes how glucagon-like peptide-1 (GLP-1)–based medicines reduce systemic and tissue inflammation through both weight-dependent and weight-independent mechanisms. It details preclinical and clinical evidence linking GLP-1 receptor activation to cardiovascular, renal, hepatic, neural, and joint anti-inflammatory effects while outlining uncertainties and future research needs.

4 Nov 2025