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Addition of tucatinib to the standard of care delays disease progression in HER2-positive metastatic breast cancer

Adding tucatinib (Tukysa) to first-line maintenance therapy with trastuzumab (Herceptin) and pertuzumab (Perjeta) delayed disease progression in patients with HER2-positive metastatic breast cancer, potentially extending time off chemotherapy, according to results from the phase III clinical trial HER2CLIMB-05 presented at the San Antonio Breast Cancer Symposium (SABCS), held December 9-12, 2025.

10 Dec 2025

Next-generation oral SERD therapy lowers the risk of breast cancer recurrence

In an international study led by UCLA, researchers have shown that giredestrant, a next-generation oral selective estrogen receptor antagonist and degrader (SERD), when given as an adjuvant therapy for early-stage (1-3) hormone receptor (HR)-positive, HER2-negative breast cancer, significantly lowered the risk of the disease returning when compared with standard hormone therapies long considered the backbone of treatment.

10 Dec 2025

Machine learning models can help diagnose ALS earlier from a blood sample

Using machine learning models, researchers at Michigan Medicine have identified a potential way to diagnose amyotrophic lateral sclerosis, or ALS, earlier from a blood sample, a study suggests.

10 Dec 2025

Triaptosis could be a promising strategy in the fight against cancer

Cancer remains one of the most critical global public health challenges, exerting profound social, economic, and clinical burdens while limiting gains in human life expectancy.

10 Dec 2025

Study shines new light on how cancer avoids the mitotic stopwatch pathway

When cell division (mitosis) takes too long, it can be a sign that something is wrong with the cells, for example DNA damage or chromosomal instability.

10 Dec 2025

Young adolescents participating in organized sports less likely to show oppositional-defiant behavior

Young adolescents, especially boys, who participated in organized sports between ages 6 and 10 are less likely to defy their parents, teachers and other authority figures, a new study by researchers in Canada and Italy suggests.

10 Dec 2025

Researchers map how brain networks differ in individuals at high clinical risk for psychosis

Researchers from the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), and NHG Health's Institute of Mental Health (IMH) have mapped how brain networks differ in individuals at Clinical High Risk (CHR) for psychosis, providing a new perspective on the mechanisms underlying the disease onset.

10 Dec 2025

$EpilepsyGTx raises $33 million Series A to develop single dose gene therapy for focal refractory epilepsy$

EpilepsyGTx raises $33 million Series A to develop single dose gene therapy for focal refractory epilepsy

EpilepsyGTx, a biotechnology company focused on research and development of cutting-edge gene therapies to treat refractory epilepsy, today announced it has raised $33 million in a Series A financing to advance its lead program EPY201 through Phase 1/2a clinical trials.

10 Dec 2025

VALANX Biotech establishes Board of Directors

VALANX Biotech (VALANX), a biotech company developing novel antibody-drug-conjugate (ADC) assets enabled by its GoldenSite™ site-specific protein conjugation technology, today announced the formation of its Board of Directors.

10 Dec 2025

$Tec-Dara could represent a new standard of care for relapsed or refractory multiple myeloma$

Tec-Dara could represent a new standard of care for relapsed or refractory multiple myeloma

Patients with relapsed or refractory (R/R) multiple myeloma who received a combination of teclistamab, a bispecific monoclonal antibody, and daratumumab, a CD38-directed monoclonal antibody, were 83% more likely to be alive without disease progression compared with those who received standard second-line therapies at a median of nearly 35 months of follow-up, according to the results of a new trial presented at the 67th American Society of Hematology (ASH) Annual Meeting and Exposition.

10 Dec 2025

Pirtobrutinib shows superior outcomes compared to common first-line combination treatment for CLL/SLL

In a new trial, the Bruton tyrosine kinase (BTK) inhibitor pirtobrutinib increased the rate of survival without disease progression and was well tolerated with a more favorable safety profile when compared with bendamustine plus rituximab (BR) in patients with previously untreated chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL).

10 Dec 2025

Plan-switching, sign-up impersonations: Obamacare enrollment fraud persists

Florida resident Keith Jones says his Affordable Care Act insurance plan was changed multiple times this year without his permission. Now the 52-year-old is struggling with his health problems while facing large premium bills he says he shouldn't owe.

10 Dec 2025

National study maps where food additives come from in children’s and adults’ diets

By analysing nationally representative diet data, researchers show that food additives rarely occur alone, with children and teenagers experiencing the highest exposure to complex additive mixtures largely driven by ultra-processed foods.

9 Dec 2025

Sterilized fermented beverage targets obesity and type 2 diabetes pathways in computational study

Researchers profiled a terminally sterilized probiotic-fermented MFH beverage and identified aporphine alkaloids and flavonoids with favorable predicted ADMET properties. Integrated network pharmacology, molecular docking, and 100-ns MD simulations suggest multi-target engagement of metabolic-inflammatory pathways relevant to obesity and type 2 diabetes.

9 Dec 2025

Researchers discover new biomarker of "complicated" mild- to severe-pediatric traumatic brain injury

Researchers at the University of Pittsburgh and UPMC Children's Hospital of Pittsburgh discovered a promising new biomarker of "complicated" mild- to severe-pediatric traumatic brain injury, or TBI.

9 Dec 2025

SIRT3 deficiency worsens eustachian tube dysfunction during middle-ear infection

Middle-ear infections caused by Gram-negative bacteria remain among the most common pediatric illnesses worldwide.

9 Dec 2025

New arts and wellbeing program supports the social needs of families affected by dementia

A new arts and wellbeing program co-developed by the University of South Australia, Flinders University and the University of Adelaide shows that supporting the social needs of people living with dementia and their carers can help families rediscover connection, confidence and a sense of community.

9 Dec 2025

State-funded multidisciplinary model improves care for adults with neurodevelopmental disorders

Adults with autism spectrum disorder (ASD) and other neurodevelopmental disorders (NDDs) often lose access to specialized care once they age out of pediatric services.

9 Dec 2025

Blinking suppression reveals how the brain filters speech in noisy environments

Blinking is a human reflex most often performed without thinking, like breathing. Although research on blinking is usually related to vision, a new Concordia study examines how blinking is connected to cognitive function such as filtering out background noise to focus on what someone is trying to say to us in a crowded room.

9 Dec 2025

SwRI and Trinity researchers work on next-generation intranasal therapy for PTSD

Southwest Research Institute (SwRI) and Trinity University are developing an intranasal (IN) drug-device combination to treat post-traumatic stress disorder (PTSD).

9 Dec 2025

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Medical News

Addition of tucatinib to the standard of care delays disease progression in HER2-positive metastatic breast cancer

Next-generation oral SERD therapy lowers the risk of breast cancer recurrence

Machine learning models can help diagnose ALS earlier from a blood sample

Triaptosis could be a promising strategy in the fight against cancer

Study shines new light on how cancer avoids the mitotic stopwatch pathway

Young adolescents participating in organized sports less likely to show oppositional-defiant behavior

Researchers map how brain networks differ in individuals at high clinical risk for psychosis

EpilepsyGTx raises $33 million Series A to develop single dose gene therapy for focal refractory epilepsy

VALANX Biotech establishes Board of Directors

Tec-Dara could represent a new standard of care for relapsed or refractory multiple myeloma

Pirtobrutinib shows superior outcomes compared to common first-line combination treatment for CLL/SLL

Plan-switching, sign-up impersonations: Obamacare enrollment fraud persists

National study maps where food additives come from in children’s and adults’ diets

Sterilized fermented beverage targets obesity and type 2 diabetes pathways in computational study

Researchers discover new biomarker of "complicated" mild- to severe-pediatric traumatic brain injury

SIRT3 deficiency worsens eustachian tube dysfunction during middle-ear infection

New arts and wellbeing program supports the social needs of families affected by dementia

State-funded multidisciplinary model improves care for adults with neurodevelopmental disorders

Blinking suppression reveals how the brain filters speech in noisy environments

SwRI and Trinity researchers work on next-generation intranasal therapy for PTSD

Digital pathology and the PathoVerse: A conversation with Dr. Singh

Bioprocess Efficiency with Cell Density Monitoring

Exploring electron microscopy for plant and microbial imaging at the John Innes Centre

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