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Serum hsa_circ_101555 as a promising biomarker for hepatocellular carcinoma

Hepatocellular carcinoma (HCC) represents the most prevalent malignancy in Egypt and globally. However, non-invasive diagnostic/prognostic biomarkers for early detection of HCC are still lacking. Circular RNAs (circRNAs) are one of the promising biomarkers.

24 Apr 2025

Guilt and shame drive end-of-life treatment decisions in cancer patients

Guilt and shame – not hope for recovery – are among the most common reasons terminally ill cancer patients continue with minimally beneficial treatments at the end of life, according to Rutgers researchers.

24 Apr 2025

Antibiotic use by humans is polluting rivers across the globe, study shows

A global modeling study found that 8,500 tonnes of antibiotics from human use alone enter rivers annually, threatening aquatic ecosystems and accelerating antimicrobial resistance. Over 6 million kilometers of river length exceed safety thresholds, especially in low- and middle-income countries with limited wastewater treatment.

24 Apr 2025

New insights into the complex health economics of Alzheimer's disease and related dementias

Value in Health, the official journal of ISPOR-The Professional Society for Health Economics and Outcomes Research, announced today the publication of a special themed section of research papers that provide crucial insights into the complex health economics of Alzheimer's disease and related dementias (ADRD), offering a roadmap for future research and policy as the aging population grows and novel treatments emerge.

24 Apr 2025

Transitioning pancreatic cells show lasting epigenetic cancer traits

Johns Hopkins Medicine scientists say they have found a pattern of so-called epigenetic "marks" in a transition state between normal and pancreatic cancer cells in mice, and that the normal cells may keep at least a temporary "memory" of those cancer-linked marks.

24 Apr 2025

Novel cancer immunotherapy approach could complement existing CAR-T treatments

Researchers in South Korea have proposed a novel cancer immunotherapy approach that could complement existing CAR-T (Chimeric Antigen Receptor T-cell) treatments.

24 Apr 2025

Smoking, drinking and inactivity associated with declines in health in people as young as 36

Bad habits such as smoking, heavy drinking and lack of exercise must be tackled as early as possible to boost the odds of a happy and healthy old age.

24 Apr 2025

Exploring the science behind blank minds and conscious gaps

Mind blanking is a common experience with a wide variety of definitions ranging from feeling "drowsy" to "a complete absence of conscious awareness."

24 Apr 2025

Study pinpoints vast 'air quality deserts' across nearly 60% of US counties

Over half of U.S. counties lack air quality monitoring stations, exposing 50.7 million people, especially in rural and disadvantaged areas, to invisible pollution risks. The study links monitoring gaps to systemic inequities and urges equitable infrastructure expansion.

24 Apr 2025

AI tools improve detection of key immune structures in melanoma

Researchers from the ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) have applied AI-driven processes for detecting tertiary lymphoid structures (TLS) in thousands of digital images of melanoma tumor tissue, significantly enhancing TLS identification and survival predictions for operable stage III/IV patients.

24 Apr 2025

New graph design helps doctors better assess blood pressure

If a picture is worth a thousand words, how much is a graph worth? For doctors trying to determine whether a patient's blood pressure is within normal range, the answer may depend on the type of graph they're looking at.

24 Apr 2025

Babies in crisis settings show remarkable social abilities

Babies living as refugees have some of the same social skills as children with more secure home conditions.

24 Apr 2025

Urgent action needed to protect children from extreme heat in schools and child care settings

As Canadians face increasingly intense and frequent heat waves, health, education and legal experts are sounding the alarm on a growing crisis: extreme heat in schools and child care settings due to the escalating effects of climate change.

24 Apr 2025

lncRNAs shape the tumor microenvironment and drive cancer development

The tumor microenvironment (TME) is a complex and dynamic network consisting of tumor cells, immune cells, stromal cells, extracellular matrix (ECM), cytokines, and growth factors, all interacting to influence tumorigenesis, progression, and metastasis.

24 Apr 2025

What’s behind Gen Z’s skepticism about Ozempic and Wegovy

A U.S. study of over 500 youth aged 14–24 found high awareness but widespread hesitation about using semaglutide for weight loss. Concerns focused on safety, social stigma, and a preference for lifestyle changes like diet and exercise.

24 Apr 2025

Manipulating a master regulator prevents tumor growth in mice

A protein identified nearly 40 years ago for its ability to stimulate the production of red blood cells plays a surprising, critical role in dampening the immune system's response to cancer.

24 Apr 2025

Common diabetes drug can reduce the pain of people with knee osteoarthritis and obesity

A common diabetes drug can reduce the pain of people with knee osteoarthritis and overweight or obesity, possibly delaying the need for knee replacements, Monash University-led research has found.

24 Apr 2025

Autistic traits do not impact age-related decline in spatial working memory

There is no difference over time in the spatial working memory of older people who have autistic traits and those who are neurotypical, finds a new study led by UCL researchers.

24 Apr 2025

Heart failure patients benefit from medically tailored meals after discharge

A new study, published in BMC Nutrition, demonstrates that providing medically tailored meals (MTM) to patients with heart failure (HF) and malnutrition risk following hospital discharge significantly improves their nutritional status and keeps hospital readmission rates well below local and national averages.

24 Apr 2025