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Study elucidates mechanisms behind G protein selectivity and efficacy in adenosine A2A receptor

In a groundbreaking study, a multinational research team led by Dr. Adnan Sljoka (RIKEN) and Prof. Akio Kitao (Tokyo Tech), in collaboration with Prof. Scott Prosser (University of Toronto), has carried out experimental and computational studies to elucidate the mechanisms behind G protein selectivity and efficacy in the human adenosine A2A receptor (A2AR).

1 Aug 2024

Comprehensive meta-analysis offers insights into strategies for increasing immunization uptake

Vaccines are safe and effective, and help reduce death and illness. But global vaccination rates are suboptimal and have trended downward, leaving humanity more vulnerable to vaccine-preventable diseases such as COVID-19, influenza, measles, polio, and HPV.

1 Aug 2024

Telemedicine usage can have unexpected impact on rural communities' access to local care

Remote healthcare delivery, commonly known as telehealth or telemedicine, is often beneficial for patients who have difficulty visiting their preferred healthcare providers in person.

1 Aug 2024

Age and cultural pressures shape body appreciation among women worldwide

A study in PLOS ONE reveals that body appreciation is significantly influenced by ethnicity and sociocultural pressures, with Black Nigerian women reporting the highest satisfaction and White Western women the lowest.

1 Aug 2024

Blowflies linked to bird flu spread in southern Japan

Researchers from Kyushu University have discovered that blowflies, a family of flies strongly attracted to decaying flesh and feces, are carrying the bird flu virus in southern Japan.

1 Aug 2024

Uncontrolled hypertension: A persistent threat to global health

In the United States and worldwide, cardiovascular disease is the leading avoidable cause of premature death and disability. Primarily heart attacks and stroke, cardiovascular disease accounts for more than 900,000 annual deaths nationally and about 10 million deaths globally.

1 Aug 2024

KFF Health News' 'What the Health?': Abortion heats up presidential race

The change at the top of the likely Democratic presidential ticket is prompting both abortion rights and anti-abortion organizations to recalibrate their campaigns, even as they fight over finalizing fall ballot proposals in many states.

1 Aug 2024

$Study reveals obesity's impact on muscle structure in heart failure with preserved ejection fraction$

Study reveals obesity's impact on muscle structure in heart failure with preserved ejection fraction

A new small study led by Johns Hopkins Medicine researchers and published July 25th in the journal Nature Cardiovascular Research has revealed the impact of obesity on muscle structure in patients having a form of heart failure called heart failure with a preserved ejection fraction (HFpEF).

1 Aug 2024

Vanderbilt to introduce focused ultrasound for treating essential tremor and Parkinson's disease

The movement disorder neurology and neurosurgery team at Vanderbilt University Medical Center is set to add focused ultrasound treatment (FUS) as a new tool in the treatment of essential tremor and Parkinson's disease.

1 Aug 2024

New lab technique captures aging effects in Alzheimer's disease development

Researchers at Washington University School of Medicine in St. Louis have developed a way to capture the effects of aging in the development of Alzheimer's disease.

1 Aug 2024

Study suggests climate anomalies contribute to cholera strain emergence

New research suggests that an El Niño event may have aided the establishment and spread of a novel cholera strain during an early 20th-century pandemic, supporting the idea that climate anomalies could create opportunities for the emergence of new cholera strains.

1 Aug 2024

New studies reveal common DNA replication mechanisms in humans and yeast

Humans and baker's yeast have more in common than meets the eye, including an important mechanism that helps ensure DNA is copied correctly, reports a pair of studies published in the journals Science and Proceedings of the National Academy of Sciences.

1 Aug 2024

Study highlights barriers to exercise for people with disabilities

An estimated 16% of people worldwide live with a significant disability that impacts their daily life. Of this population, only about 40% engage in aerobic activity.

1 Aug 2024

Aspirin may lower colorectal cancer risk for people with unhealthy lifestyles

Regular aspirin may help lower risk of colorectal cancer in people with greater lifestyle-related risk factors for the disease, according to a study led by researchers at Mass General Brigham.

1 Aug 2024

Fish oil may benefit older adults with genetic Alzheimer's risk

A clinical trial at Oregon Health & Science University suggests that a subset of older adults with a genetic predisposition to Alzheimer's disease may benefit from fish oil supplements.

1 Aug 2024

Applying antifragility theory to cancer could revolutionize treatment methods

Researchers constantly seek innovative approaches to tackle cancer. One concept gaining traction is antifragility, a property where systems not only withstand stress but improve because of it.

1 Aug 2024

Indoor fireplaces linked to harmful airborne particles and health risks

During the cold winter months, it is nice to light an indoor fireplace for extra warmth or to have the occasional ‘braai’. The downside is that you may be inhaling tiny solid or liquid substances that could be harmful to your health.

1 Aug 2024

New nanosensing technique enhances quality control for gene therapy vectors

Over the past few decades, there has been remarkable progress in genetic manipulation technologies, bringing us closer to the point where genes can be modified in vivo.

1 Aug 2024

Novel electrical impedance technique enhances drug testing for cardiac safety

When developing new drugs, understanding their effects on ion channels in the body, such as the human ether-a-go-go-related gene (hERG) ion channel found in neurons and heart muscle cells, is critical.

1 Aug 2024

Study reveals how geographic origins influence tuberculosis infection risk

For some forms of tuberculosis, the chances that an exposed person will get infected depend on whether the individual and the bacteria share a hometown, according to a new study comparing how different strains move through mixed populations in cosmopolitan cities.

1 Aug 2024