News Medical's "Thought Leaders" series is a selection of articles written by national and
international experts and trusted advisers in health and medicine. All the articles are
written by experts who have been invited as recognised leaders in their fields to provide
a "state of the art" contribution.
Meningitis is a relatively rare disease, with our estimates for the incidence of meningitis in the UK being about 3.2 cases of meningitis per 100,000 adults. Crucially, bacterial meningitis is linked to significant morbidity and mortality - up to 30% mortality in pneumococcal meningitis cases.
Claire is Evidence & Policy Manager at the UK and international charity Meningitis Research Foundation (MRF). She discusses the signs and symptoms of meningitis in newborns, and the aims for the recent diagnostic eTool developed by the MRF.
Parry outlines her research in diagnosing depression, which led to her winning the Pittcon 2018 Achievement Award.
The microbiome is the collection of microorganisms that colonize the human body. Dr. Jasmohan Bajaj discusses the relationship between the microorganisms in the gut and cirrhosis, and how microbiome analysis can be used to predict the risk of cirrhosis-associated hospitalizations.
An interview with Prof. John Richie, describing his presentation at Pittcon 2018 on free radical formation in electronic cigarette aerosols.
An interview with Rebecca Sanders, Lipodystrophy UK co-founder, discussing the importance of awareness campaigns for patients and society at large.
Currently, there are an estimated 46 million people worldwide living with dementia. There is currently no cure, and no way to prevent the onset of dementia. The Wayback Project was created by a group of friends and former colleagues who wanted to create virtual reality films that allow patients to go 'back in time'.
Preterm birth is a dangerous condition that often goes undiagnosed. Fetal fibronectin (fFN) is a biomarker for preterm labor, but testing for fFN is widely underused. We explore this issue with Dr. Michael S. Ruma, a maternal-fetal specialist from the Perinatal Associates of New Mexico.
Dr. Castro is a translational oncologist with experience developing and harnessing nanotechnology and molecular imaging platforms for cancer purposes. His work offers a “less is more” approach — to generate robust cancer analyses using scant amount of specimens. Dr. Castro’s research has included funding from the V Foundation for Cancer Research, National Institutes of Health, Ovarian Cancer Research Fund, and the Department of Defense.
An interview with Dr Gareth Evans about the future of breast cancer screening and the implementation of single nucleotide polymorphism (SNP) profiling.
Developing analytical methods can help the triers of fact, judges and juries, better understand the events surrounding the circumstances of a crime. In forensic analysis, we are talking about determining the identity of unknown individuals through DNA and using DNA and other chemical signatures to determine and clarify the circumstances of the crime.
When a coronary artery is obstructed by atheroma, blood flow is depressed or even arrested. This causes hypoxia of cardiac cells associated with the deprivation of nutrients. In clinic, the first objective is to restore blood flow. However, this is associated with a burst in oxidation of cellular proteins and lipids. This oxidation enhances cell death and participates to the so-called reperfusion injury.
My name is James Gimzewski and I am a distinguished professor at UCLA. I'm in the Chemistry and Biochemistry department, but I am also heavily involved in the California NanoSystems Institute at UCLA. We were probably the first to pioneer the idea of what is now known as mechanobiology – the study of the mechanical properties of cancer cells as a potential diagnostic tool.
I run a core facility for AFM techniques, biological medical applications. My research is focussed on in the interaction of platelets and cancer cells.
Force microscopy is a technique which would probably be best described with the help of a small finger with an apex just a few atoms in size that can touch objects. This is a learning finger.
My group is interested in host pathogen interaction and we mainly focus on how bacteria enter cells. In essence, the idea is that if you can prevent bacteria from entering cells, then you will prevent illness.
My lab, broadly speaking, is interested in trying to understand interactions between cells and materials. Those could be materials that are present within living tissue or materials that we use for engineering purposes to try to do something of technological or therapeutic interest.
Biomarkers fall into different categories: diagnostic biomarkers, are used to identify a disease; prognostic biomarkers, help clinicians to determine, for example, whether you're more likely to die or have problems with a disease; and there are some that can be used to inform treatment, to determine whether one therapy would be more successful than another.
Vital signs have been around for a long period of time. Taking the pulse is probably one of the oldest examinations that doctors have made to assess patients.
Pittcon is an analytical conference, so naturally my talk will be about analytical chemistry and how analytical chemistry will become increasingly important in delivering healthcare solutions, not only for rich people, but also, hopefully, for poor people across the world.