New hope for emphysema sufferers

Researchers at the University of Pennsylvania School of Medicine are now studying an investigational treatment that may offer a significant new, minimally-invasive option for those suffering from advanced widespread emphysema.

The EASE (Exhale Airway Stents for Emphysema) trial focuses on a procedure called airway bypass that involves creating pathways in the lung for trapped air to escape -- and in turn, may relieve emphysema symptoms including shortness of breath.

Emphysema, most often brought on by smoking, affects an estimated 60 million people worldwide with more than 3 million sufferers in the United States. There is no cure. It's a chronic, progressive, and irreversible lung disease characterized by the destruction of lung tissue. The loss of the lungs' natural elasticity and the collapse of airways in the lung combine so that the lungs can no longer deflate to let air in. The patient is in a permanent state of "breathlessness", sucking in rapid, shallow breaths. Even the most nominal physical activities become difficult for emphysema patients and many become dependent on oxygen therapy.

There are limited treatment options right now for these patients who struggle for each breath," comments John Kucharczuk, MD, principal investigator, thoracic surgeon, and Assistant Professor of Surgery at Penn. "This new, cutting-edge, non-surgical procedure actually creates new pathways for airflow and could offer another option for those who would otherwise possibly spend years waiting on a lung transplant list."

During the airway bypass procedure, physicians first use a Doppler probe inserted through a flexible bronchoscope (a commonly used way to go through the mouth and into the lungs to examine the airways) to identify sites away from blood vessels. Then the physician creates new small pathways using a special needle to make small openings. Stents are then put in place to keep the new passageways open.

The procedure involves placing up to six Exhale, Drug-Eluting Stents, manufactured by Broncus Technologies, Inc. - to allow the trapped air in the lung to escape. Again, it is hoped this will deflate the lungs, by essentially creating a few new unobstructed air pathways, so that the patient can breathe more easily. The total time of the procedure is approximately one to two hours.

Daniel Sterman, MD, co-principal investigator of the study and Director of Interventional Pulmonology at Penn, states, "This experimental technique could be revolutionary as it is the only approach being examined right now which targets the population of emphysema patients whose disease has destroyed tissue throughout the lung -- and not just the upper lung zones. This technique would help those who do not appear to benefit from lung volume reduction surgery."

Sterman adds, "Given that emphysema is such a devastating disease associated with permanent destruction of the small air sacs (alveoli) which allow the lungs to function -- any new potential intervention could offer substantial relief to the millions of sufferers in this country."


The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
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