Molecular Biometrics' ViaMetrics-E procedure accurately predicts implantation rates in SET IVF cycles

Researchers from Molecular Biometrics, Inc. presented new data this week demonstrating that the company's ViaMetrics-E procedure more accurately predicts implantation rates in single embryo transfer (SET) cycles for patients undergoing infertility treatment. ViaMetrics-E  is a rapid, non-invasive procedure used to enhance in vitro fertilization (IVF) outcomes by identifying viable embryos having the greatest reproductive potential. These research findings were presented this week at the 26th annual meeting of the European Society for Human Reproduction and Embryology (ESHRE) in Rome.

ViaMetrics-E is now available commercially in select countries in Europe, Asia and the Pacific Rim. The company expects to launch the product in other countries in Europe and Asia later this year. Molecular Biometrics is currently working to complete the necessary regulatory requirements to market the product in the U.S.

"Single embryo transfer is a significant and growing trend in infertility treatment in many countries, designed to help reduce the number of multiple births, and the costs and complications associated with them. Providing infertility specialists with greater confidence in identifying the best embryo(s) for transfer clearly supports this growing worldwide clinical focus," said James T. Posillico, Ph.D., President and Chief Executive Officer, Molecular Biometrics. "ViaMetrics-E, when used in conjunction with morphology -- the standard visual assessment of embryos -- gives infertility specialists a valuable new tool to more accurately predict implantation rates while reducing the potential of multiple births. Molecular Biometrics believes this is beneficial for patients, infertility specialists and the healthcare system overall."

Data described in a podium presentation delivered by Denny Sakkas, Ph.D., Adjunct Associate Professor, Yale University School of Medicine, Director of the Embryology Laboratory at Yale Fertility Center, and Molecular Biometrics' Chief Scientific Officer, indicate that differences in ViaMetrics-E Viability Scores could have an impact on which embryo to transfer in a patient's individual IVF cycle, and increase the potential for a successful pregnancy. Each Viability Score reflects the "health" or reproductive potential of the developing embryo.  

In this study, spent culture media from 439 embryos from 114 patients were analyzed. Results of this study showed that Day 5 embryos of similar morphology recorded a wide variation in Viability Scores. The data further show that Day 5 embryos with the best morphology within the cohort had the best Viability Scores in only 26% of the cases, indicating that, in 74% of cases, a different embryo may have been identified for transfer using ViaMetrics-E. The authors concluded that choosing embryos with the best metabolic profiles within a cohort, in addition to morphology, could have a significant impact on the identification of the best embryos for SET.

"Because only one embryo is transferred during a single embryo transfer, identifying the embryo with the greatest reproductive potential is critical," added Sakkas. "The non-invasive assessment of embryo culture using ViaMetrics-E technology can give clinicians greater confidence in identifying embryos with the highest potential for successful implementation, directly supporting the greater adoption of SET."

Results from two other studies presented at the ESHRE conference further demonstrated the role ViaMetrics-E might play in identifying the best embryo for single embryo transfer.

Data presented by Emre Seli, M.D., Associate Professor of Reproductive Endocrinology and Infertility at Yale University School of Medicine and Chair of Molecular Biometrics' Scientific Advisory Board, compared the assessment of morphology, Viability Scores produced by ViaMetrics-E and a combination of morphology and Viability Scores in the evaluation of an embryo's reproductive potential (determined by an embryo's positive and negative fetal cardiac activity (FCA) at 12 weeks of gestation). Analysis of 209 spent embryo culture media samples collected following Day 5 SET cycles from five IVF centers in the U.S., Europe and Australia indicated that a ViaMetrics-E Viability Score more accurately predicts embryo implantation rates than does morphology alone. The authors concluded that metabolic assessment of an embryo could yield up to 15% better predictability than morphology alone.

Data presented by Lucy Botros, M.Sc., Molecular Biometrics, assessed the accuracy of ViaMetrics-E in predicting the implantation potential of individual embryos. In an international, multi-center study, 248 spent culture media samples from eight infertility centers in the U.S., Europe and Australia were collected following single embryo transfer on Day 2>ViaMetrics-E can assist in the identification of embryos with the greatest reproductive potential.  

Source:

Molecular Biometrics, Inc.

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