Pulse Therapeutics receives fund to develop novel magnetics technique to destroy blood clots

BioGenerator, a non-profit, seed-stage economic development funding group, today announced that it has led a round of early-stage financing for Pulse Therapeutics, Inc., a St. Louis company headquartered at the Center for Emerging Technologies. Pulse Therapeutics develops innovative magnetism-based technology to safely destroy blood clots related to ischemic stroke and deep vein thrombosis (DVT). Other investors who participated in the round were Missouri Technology Corporation (MTC), Washington University's Olin School of Business Skandalaris Student Venture Fund, and Integrated Magnetics, of Culver City, California. The funds will be used for further pre-clinical development.

“BioGenerator is enthusiastic about working with such a highly skilled and experienced team of founders, and we are pleased to provide funding and other support for critical pre-clinical proof-of-concept studies designed to evaluate the therapeutic capability of this promising early-stage technology.”

Pulse Therapeutics' technology has the potential to significantly improve the standard of care for the treatment of ischemic stroke and deep vein thrombosis, from which a combined number of approximately 400,000 Americans die each year. Current approaches to remove clot material from the endovascular system rely on high doses of thrombolytics (lytics or clot-busting drugs), which can induce life-threatening bleeding. Also, the aggressive nature of current medical devices used to enhance lytic therapy can result in damage to blood vessels or leaflet valves. Because Pulse Therapeutics' technology is less likely to result in negative secondary effects on the vascular system, and because it targets and amplifies a much lower dose of lytic drugs for stroke therapy, it could provide a safer, more effective treatment, which would enable the therapy to be offered to more patients.

Pulse Therapeutics' founders, Francis Creighton, Ph.D., and Rogers Ritter, Ph.D., were former scientists at Stereotaxis, Inc. The company's scientific advisory board is comprised of leading clinicians, including Washington University faculty members Dr. Ralph Dacey, Professor and Chairman of Neurosurgery; Dr. Colin Derdeyn, Professor of Radiology and Associate Professor of Neurology and Neurological Surgery; and Dr. Patrick Geraghty, Associate Professor of Surgery and Radiology. The scientific advisory board also includes Washington University faculty member, Dr. Michael Talcott, Research Assistant Professor of Surgery and Neurosurgery and Director of Veterinary Surgical Services, and Dr. Eric Gulve, President of BioGenerator.

Dr. Eric Gulve stated, "We have identified this as an exciting example of the potential for medical device technology to substantially improve the utility of existing medicines. Use of Pulse Therapeutics' technology for treatment of deep vein thrombosis and stroke offers the promise of multiple benefits to patients with these life-threatening conditions while reducing the financial burden on our healthcare system. Possible benefits also include improved effectiveness and a reduction in serious side effects, the ability to offer therapy to more patients in need, and an expansion of the pool of physicians able to deliver therapy." Gulve continued, "BioGenerator is enthusiastic about working with such a highly skilled and experienced team of founders, and we are pleased to provide funding and other support for critical pre-clinical proof-of-concept studies designed to evaluate the therapeutic capability of this promising early-stage technology."

Jason Hall, Executive Director of Missouri Technology Corporation, said, "Pulse Therapeutics is precisely the kind of cutting-edge company that we need to keep in our state to create high-paying jobs for Missourians for years to come. MTC is pleased to join our regional partners to support the growth of Pulse and to retain sought-after medical device entrepreneurs like Drs. Creighton and Ritter in the St. Louis region."

"I am delighted that Pulse Therapeutics has received initial funding for its promising and novel application of advanced magnetics using nanoparticles for the treatment of stroke and other vascular disorders," remarked Bevil J. Hogg, CEO of EndoStim.

Pulse Therapeutics' technology has also attracted investment from outside of the region. Anil Nanji, President of Integrated Magnetics, stated, "We believe that Pulse Therapeutics has a very strong technical leadership team with the added benefit of its founders having learned valuable commercial, regulatory, and business lessons through their involvement in other medical device ventures. The product appears to significantly enhance the effectiveness of existing medications . . . reducing the risks inherent in new product introductions in the medical device arena."

Former Stereotaxis CTO, Peter Werp, said of his contribution to the recent funding, "My confidence in the Pulse Therapeutics team, its technology, and the clinical potential, has led me to participate alongside the institutional investors." Werp explained, "Two chronic problems in health care are cost and access. Pulse Therapeutics' technology, when proven and made available to the medical community, should reduce the cost of safely breaking up blood clots in both deep vein thrombosis and ischemic stroke. By using ultrasound instead of more expensive and specialist-limited angiography to manage the procedure, and because of the technology's low capital and procedure costs, it offers the possibility of becoming widely available to stroke clinics, outpatient clinics, and emergency rooms, and could expand access to more patients."




The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
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