Dyadic second-quarter 2010 total revenue decreases to $2.2 million

Dyadic International, Inc. ("Dyadic") (Pink Sheets: DYAI), a global biotechnology company focused on the discovery, development, manufacture and sale of specialty enzyme products and solutions for the bioenergy, industrial enzyme and biopharmaceutical industries, today announced financial results for the second quarter ended June 30, 2010. The financial information contained in this press release should be read in conjunction with the financial statements and related footnotes which have been posted on the Pink Sheets website at www.pinksheets.com and on Dyadic's website at www.dyadic.com.

Dyadic's President and Chief Executive Officer, Mark Emalfarb, stated, "During the second quarter, we made significant progress in positioning Dyadic for future long-term growth by continuing to enhance our C1 technology and hiring key personnel and advisors to unlock the value of that technology primarily in the areas of biofuels and chemicals. We also laid the foundation to apply our C1 technology to the development and commercialization of biopharmaceuticals. All of this is now being pursued without the overhanging risk, cost and distraction of protracted stockholder litigation which we have put behind us."

Recent Company Highlights

In 2010, Dyadic has made significant progress in the following areas:

General

• Achieved final resolution of the stockholder class action lawsuit.

Research & Development

• Continued to improve the efficiency and performance of our enzymes for use in creating new industrial enzyme products and enhancing our current product offerings in the areas of animal feed, pulp and paper, starch and alcohol, food and brewing, textiles and alternative fuels.
• Continued to enhance our C1 technology in collaboration with Scripps Florida, a division of the Scripps Research Institute, and Dyadic Netherlands, for greater applicability in producing higher enzyme yields at lower cost for the benefit of our licensing and research partners.
• Initiated several provisional patent applications on genes and the enzymes they encode which resulted from ongoing research programs.
• Dedicated a greater portion of Dyadic's research and development capabilities to revenue generating collaborations including the use of our C1 technology for expressing proteins and enzymes in higher quantities from the genes provided by third parties.

Biofuels

• Engaged the Abraham Group LLC and former U.S. Energy Secretary, Spencer Abraham, as a strategic advisor to implement an international initiative designed to identify potential licensees and strategic partners for Dyadic among major international companies who have demonstrated strong interest in alternative energy and to assist in consummating those transactions.
• Initiated and continued ongoing discussions with several major companies for the potential license of Dyadic's C1 technology for the development and commercialization of biofuels and biochemicals.

Biopharmaceuticals

• Entered into a term sheet for a potential exclusive outlicense of C1 technology for biopharmaceutical applications to EnGen Bio, Inc.
• Continued discussions with numerous companies and investors regarding the potential funding of EnGen Bio as well as ongoing negotiations with a third party to conduct proof-of-concept scientific studies to validate the C1 technology's ability to meet certain protein expression levels as a condition of such funding.

Industrial Enzymes

• Improved product margins from 20% to 33% for the year to date.
• Continued discussions and negotiations with several companies for the potential license of Dyadic's C1 technology for animal feed and food applications.
• Strengthened Dyadic's leadership team through the hiring of a Vice President Sales & Marketing.
• Introduced and launched two new enzymes for the textiles market.
• Increased production capacity.

Financial Results

Total revenue for the second quarter ended June 30, 2010 decreased to approximately $2.2 million compared to approximately $11.9 million for the second quarter ended June 30, 2009. Total revenue for the six months ended June 30, 2010 decreased to approximately $4.2 million compared to approximately $16.9 million for the six months ended June 30, 2009. The decrease in total revenue for the three month period ended June 30, 2010 as compared to the three month period ended June 30, 2009 was due to a decrease in licensing revenue. The decrease in total revenue for the six month period ended June 30, 2010 as compared to the six month period ended June 30, 2009 was due to a decrease in research and development revenue and licensing revenue as described below.

Net product related revenue for the second quarter remained essentially flat at approximately $1.7 million. Net product related revenue for the six months ended June 30, 2010 increased to approximately $3.6 million from approximately $3.2 million for the same period a year ago.

Research and development revenue for the second quarter ended June 30, 2010 increased to approximately $465,000 compared to approximately $396,000 for the second quarter ended June 30, 2009. Research and development revenue for the six months ended June 30, 2010 decreased to approximately $554,000 compared to approximately $3.9 million for the six months ended June 30, 2009. The decrease in research and development revenue for the six months ended June 30, 2010 compared to the six months ended June 30, 2009 was due to research and development revenue recognized in the first quarter of 2009 of $3.3 million received from Abengoa Bioenergy R&D, Inc. pursuant to a securities purchase agreement between Dyadic and Abengoa.

There was no license fee revenue for the second quarter ended June 30, 2010 compared to license fee revenue of approximately $9.8 million for the second quarter ended June 30, 2009. License fee revenue for the six months ended June 30, 2010 decreased to approximately $32,000 compared to approximately $9.8 million for the six months ended June 30, 2009. The decrease in license fee revenue for the three and six month periods ended June 30, 2010 compared to the three and six month periods ended June 30, 2009 was due to licensee fee revenue recognized in the second quarter of 2009 of approximately $9.8 million related to license fees received from Codexis, Inc. pursuant to the non-exclusive license agreement between Codexis and Dyadic.

Gross margins for net product related revenue, exclusive of shipping and other costs, increased to 33% for the six months ended June 30, 2010 compared to 20% for the six months ended June 30, 2009 as a result of the continued focus on more profitable product lines and improvements to inventory management and overall operating efficiencies.

Net loss for the second quarter ended June 30, 2010 was approximately $1.4 million, or $(0.05) per basic and diluted share, compared to net income of approximately $8.6 million, or $0.29 per basic and $0.26 per diluted share for the second quarter ended June 30, 2009. Net loss for the six months ended June 30, 2010 was approximately $2.5 million, or $(0.08) per basic and diluted share, respectively, compared to net income of approximately $10.9 million, or $0.36 per basic and $0.33 per diluted share, for the six months ended June 30, 2009.

At June 30, 2010, cash and cash equivalents were approximately $4.0 million compared to approximately $8.4 million at December 31, 2009. A significant portion of the decrease in cash and cash equivalents since the end of last year was due to costs incurred and payments by Dyadic to resolve the stockholder class action lawsuit.