Santaris Pharma advances SPC4955 into Phase 1 trial for high cholesterol treatment

Santaris Pharma A/S, a clinical-stage biopharmaceutical company focused on the research and development of mRNA and microRNA targeted therapies, today announced that it has advanced a second drug from its cardiometabolic program, SPC4955 into Phase 1 clinical trials, for the treatment of high cholesterol. Developed using Santaris Pharma A/S proprietary Locked Nucleic Acid (LNA) Drug Platform, SPC4955 is a mRNA-targeted drug candidate that inhibits apolipoprotein B (apoB), a major protein component involved in the formation of low density lipoprotein cholesterol (LDL-C) or "bad" cholesterol.

Cholesterol is an essential component of all cells and several important hormones, but cholesterol levels that are out of balance or too high overall lead to the formation of atherosclerotic plaques that cause cardiovascular diseases such as heart attacks or strokes. According to the World Health Organization, cardiovascular disease is the number one cause of death globally and high cholesterol is estimated to cause 18% of strokes and 56% of heart disease globally.

The randomized, dose-escalation, double-blind, placebo-controlled Phase 1 study will assess safety, tolerability, pharmacokinetics, and pharmacodynamics of SPC4955. The study aims to enroll 30 healthy volunteers who will be randomized to receive either subcutaneous injections of SPC4955 or placebo. In preclinical studies, SPC4955 potently and dose-dependently inhibited the synthesis of apoB resulting in significant and durable reductions in plasma levels of LDL-C and triglycerides.

Last week, Santaris Pharma A/S announced it had advanced another drug candidate, SPC5001, a mRNA- targeted drug inhibiting the synthesis of Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9), for the treatment of high cholesterol into Phase 1 clinical trials. PCSK9 is a protein involved in removing low density lipoprotein cholesterol (LDL-C) or "bad" cholesterol from the bloodstream.

"Advancing two drug candidates, SPC4955 and SPC5001, in the space of only a week from our cardiometabolic program into the clinic is a testament to the efficiency of our LNA Drug Platform and Drug Discovery Engine capabilities and represents an important step for patients as multiple approaches are needed to lower high cholesterol levels," said Arthur A. Levin, PhD, Vice President and Chief Development Officer of Santaris Pharma A/S. "SPC4955 aims to inhibit the production and export of LDL-C in the liver while our other clinical candidate SPC5001, increases the clearance of LDL from the blood. Working on two distinct compounds with different target pathways allows the company to address the broad spectrum of patients trying to control their high cholesterol levels."

In addition to its cardiometabolic programs, in September 2010, Santaris Pharma A/S successfully advanced miravirsen, a lead microRNA drug candidate targeting miR-122, into Phase 2 studies for the treatment of patients infected with the Hepatitis C virus.

The LNA Drug Platform and Drug Discovery Engine developed by Santaris Pharma A/S combines the Company's proprietary LNA chemistry with its highly specialized and targeted drug development capabilities to rapidly deliver potent single-stranded LNA-based drug candidates for a range of diseases including metabolic disorders, infectious and inflammatory diseases, cancer and rare genetic disorders.