Miltenyi Biotec enters partnership with TeutoCell to develop novel cell culture techniques

Miltenyi Biotec, the only company to offer a seamless experimental integration path from sample preparation through cell separation, culture, and analysis for primary cells, today entered into a strategic alliance with TeutoCell, a provider of cutting edge cell culture technology. The new partnership will broaden that experimental integration path to include cell culture for biomanufacturing with the addition of five novel cell culture media. The first of these, CHOMACS CD, a medium for the production of biopharmaceutical proteins, becomes available as of today.

Based on TeutoCell's cell culture medium, CHOMACS CD has been successfully tested with 11 cell lines and clones, including CHO K1, CHO DP-12, and CHO DHFR-. It provides a low osmolality to reach an optimal basis for fedbatch processes, and is capable of creating cell concentrations of 1.5x107 cells/mL and beyond, depending on cell line. CHOMACS CD forms the two companies' base medium, and will soon be followed by a feed supplement.

"Every CHO clone reacts differently to different media, which can be a real pain for development teams when new clones are used to produce new biopharmaceuticals," explains Dr. Bernd Schroder, Head of Production Upstream Processing, Miltenyi Biotec. "CHOMACS CD is an excellent choice for a large range of clones, which means betting on Miltenyi Biotec is likely to save them a big headache."

To broaden the product spectrum and create more value for their customers, in addition to a feed medium for CHO cells, TeutoCell and Miltenyi Biotec are currently developing specialized culture media for HEK and Hybridoma cells. All media are chemically defined, animal component- and protein-free, or with low protein content, facilitating downstream purification and regulatory compliance. TeutoCell's media development and optimization methodologies involve parallel cultivation and data modeling for the most rational, effective, and customer-centric design of cell culture media.

"TeutoCell is committed to continually improving cell culture technology, while Miltenyi Biotec's expertise in cell processing, cell analysis and GMP production makes it an ideal partner for us to develop innovative technologies," concludes Stefan Northoff, CEO, TeutoCell AG.