Curemark's novel compound CM-182 shows promise for treatment of hyperactivity without sedation

Curemark, LLC, a drug research and development company focused on the treatment of neurological diseases, announced today that its compound CM-182 demonstrated positive results for reduction in hyperactivity in mice treated with amphetamines. The mouse model screening was performed by the contract research organization, Cerca Insights.

The data indicated that the amphetamine-injected C57BL/6 mice exhibited a dose dependent reduction in hyperactivity when administered CM-182. Administration of CM-182 to control mice demonstrated no sedating effects, suggesting that the reduction of hyperactivity in the amphetamine induced mice was not due to any sedating effect of the compound.

"Our findings in the C57BL/6 mouse model with amphetamine induced hyperactivity are consistent with findings of other psychotropic medications utilized to treat hyperactivity, but without the sedating effects," states James Szigethy R.Ph., Director of Curemark Research and Development. "This further reinforces our previous findings using CM-182 to reduce hyperactivity in the ckr (chakragati) mouse model of schizophrenia."

"We are excited by these findings," states Dr. Joan Fallon, CEO of Curemark. "Our results demonstrate that our novel compound indeed shows promise for the treatment of hyperactivity without sedation. Hyperactivity is generally treated with a multiplicity of drugs that cause major sedation, and thereby alter the quality of life of those taking the drugs."

Curemark said it intends to pursue further its investigative studies on CM-182.